Protective effect of hesperidin against N,N'-dimethylhydrazine induced oxidative stress, inflammation, and apoptotic response in the colon of Wistar rats
December 11, 2020

Protective effect of hesperidin against N,N’-dimethylhydrazine induced oxidative stress, inflammation, and apoptotic response in the colon of Wistar rats

By Dylan

Hesperidin (HD), a citrus bioflavonoid possesses quite a lot of organic actions together with antioxidant, anti-inflammatory, anti-apoptotic and anti-carcinogenic properties. Within the current examine, we investigated the impact of HD remedy on N,N’-dimethylhydrazine (DMH) induced oxidative stress, irritation, apoptosis and goblet cell disintegration within the colon of Wistar rats. Administration of HD was accomplished at two doses (100 and 200 mg/kg physique weight) orally to rats each day for <em>14</em> days adopted by a single subcutaneous injection of DMH (40 mg/kg physique weight) on the <em>14</em>th day and subsequent day animals had been sacrificed.

The protecting potential of HD towards colon toxicity was measured by membrane oxidation, antioxidant standing, inflammatory and apoptotic markers expression, and histological adjustments. Outcomes demonstrated that HD inhibited DMH mediated oxidative harm by diminishing the extent of peroxidation of lipids and rising the exercise of superoxide dismutase, catalase, diminished glutathione, glutathione peroxidase, glutathione-s-transferase, and glutathione reductase. Furthermore, HD attenuated inflammatory (NF-кB, IL-6, and COX-2) and apoptotic (p38-MAPK, p53, and <em>caspase</em>-3) markers expression.

HD additionally attenuated the DMH induced goblet cell disintegration and restored histoarchitecture of the colon. The outcomes of the current examine exhibit that HD effectively protects towards DMH induced colon toxicity by modulating oxidative stress, irritation, and apoptosis.

 

Molecular subtype-specific responses of colon most cancers cells to the SMAC mimetic Birinapant

Colorectal most cancers is a molecularly heterogeneous illness. Responses to genotoxic chemotherapy within the adjuvant or palliative setting differ drastically between sufferers, and colorectal most cancers cells typically resist chemotherapy by evading apoptosis. Antagonists of an inhibitor of apoptosis proteins (IAPs) can restore faulty apoptosis signaling by degrading cIAP1 and cIAP2 proteins and by inhibition of XIAP. Because of the a number of molecular mechanisms-of-action of those targets, responses to IAP antagonist could differ between molecularly distinct colon most cancers cells. On this examine, responses to the IAP antagonist Birinapant and oxaliplatin/5-fluorouracil (5-FU) had been investigated in <em>14</em> colon most cancers cell strains, representing the consensus molecular subtypes (CMS). Therapy with Birinapant alone didn’t lead to a considerable enhance in apoptotic cells on this cell line panel.
Annexin-V/PI assays quantified by circulate cytometry and high-content screening confirmed that Birinapant elevated responses of CMS1 and partially CMS3 cell strains to oxaliplatin/5-FU, whereas CMS2 cells weren’t successfully sensitized. FRET-based imaging of <em>caspase</em>-Eight and -Three activation validated these variations on the single-cell degree, with CMS1 cells displaying sustained activation of <em>caspase</em>-8-like exercise throughout Birinapant and oxaliplatin/5-FU co-treatment, in the end activating the intrinsic mitochondrial apoptosis pathway. In CMS2 cell strains, Birinapant exhibited synergistic results together with TNFα, suggesting that Birinapant can restore extrinsic apoptosis signaling within the context of inflammatory indicators on this subtype. To discover this additional, we co-cultured CMS2 and CMS1 colon most cancers cells with peripheral blood mononuclear cells. We noticed elevated cell loss of life throughout Birinapant single remedy in these co-cultures, which was abrogated by anti-TNFα-neutralizing antibodies.
Collectively, our examine demonstrates that IAP inhibition is a promising modulator of response to oxaliplatin/5-FU in colorectal cancers of the CMS1 subtype, and will present promise as within the CMS2 subtype, suggesting that molecular subtyping could assist as a affected person stratification software for IAP antagonists on this illness.

Protective effect of hesperidin against N,N'-dimethylhydrazine induced oxidative stress, inflammation, and apoptotic response in the colon of Wistar rats

Protective effect of hesperidin against N,N’-dimethylhydrazine induced oxidative stress, inflammation, and apoptotic response in the colon of Wistar rats

The impact of calcium phosphate biodegradable coatings of titanium implants on cell differentiation and apoptosis in rat bone tissue after experimental fracture

Background: The effectiveness of bone restore is set by the stability of proliferative and harmful elements within the fracture union web site. It may be enhanced through the use of varied nanostructured supplies possessing osteoinductive properties, particularly titanium implants with biodegradable calcium phosphate coatings. The consequences of those coatings on the state of stem cells, their differentiation and distribution within the restore zone is unknown.
Goal: To check the dynamics of proliferation, differentiation, and apoptosis of stem cells after experimental fracture adopted by implantation of titanium implants with calcium phosphate coatings
The localization of proliferation (PCNA) and differentiation (CD44 and osteocalcin) elements and apoptotic molecules (MDM2, p53, <em>caspase</em>-3) was studied in a rat femoral fracture mannequin with implant placement. Titanium implant screws with bioactive calcium phosphate and hydroxyapatite coatings fashioned by plasma electrolytic oxidation had been used within the examine. Experimental rats had been organized into three teams (15 animals per group): management group; rats implanted with uncoated implants; and rats implanted with coated implants. Management rats had been topic to the same fracture as experimental ones and had been allowed to heal conservatively. Rats from all teams had been sampled on days 7, <em>14</em>, and 30 after harm.
 Low-differentiated PCNA-, osteocalcin-, and CD44-immunopositive cells had been localized across the implant within the internal layer of the periosteum, layer of outer circumferential lamellae, and connective tissue lining of haversian canals. The spatial density of cells expressing the above proliferation and differentiation elements, in addition to that of MDM2-immunoreactive cells, elevated on day 7 and decreased by day 30 after harm. The spatial density of apoptotic cells reached the utmost on day <em>14</em> after harm. They had been primarily discovered within the internal layer of the periosteum and outer circumferential lamellae. p53- and <em>caspase</em>-3-positive cells occurred on the floor of the concentric lamellae surrounding haversian canals and below the periosteum. Their spatial density decreased by day 30 after harm.
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 . This antibody is tested and proven to work in the following applications:
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 . This antibody is tested and proven to work in the following applications:
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  • Immunogen: caspase 12(gene/pseudogene)
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Description: Antibody raised against Caspase 12
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  • Immunogen information: Synthesized peptide derived from the Internal region of human Caspase12
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Description: A polyclonal antibody for detection of Caspase 12 from Human. This Caspase 12 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Caspase12
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  • Immunogen information: Synthesized peptide derived from the Internal region of human Caspase12
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Description: A polyclonal antibody for detection of Caspase 12 from Human. This Caspase 12 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Caspase12
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  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 79.6kDa
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Description: Recombinant Mouse Caspase 12 expressed in: E.coli
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  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 31.4kDa
  • Isoelectric Point: 5.1
Description: Recombinant Rat Caspase 12 expressed in: E.coli
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  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Goat Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Goat Caspase 12 ELISA kit
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  • Show more
Description: A competitive ELISA for quantitative measurement of Goat Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Goat Caspase 12 ELISA kit
E06C0690-96 1 plate of 96 wells
EUR 685
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Description: A competitive ELISA for quantitative measurement of Goat Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rat Caspase 12 ELISA kit
E02C0690-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Rat Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rat Caspase 12 ELISA kit
E02C0690-48 1 plate of 48 wells
EUR 520
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  • Show more
Description: A competitive ELISA for quantitative measurement of Rat Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rat Caspase 12 ELISA kit
E02C0690-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Rat Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Mouse Caspase 12 ELISA kit
E03C0690-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Mouse Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Mouse Caspase 12 ELISA kit
E03C0690-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Mouse Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Mouse Caspase 12 ELISA kit
E03C0690-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Mouse Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Caspase 12 ELISA kit
E04C0690-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Rabbit Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Caspase 12 ELISA kit
E04C0690-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Rabbit Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Caspase 12 ELISA kit
E04C0690-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Rabbit Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Human Caspase 12 ELISA kit
E01C0690-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Human Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Human Caspase 12 ELISA kit
E01C0690-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Human Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Human Caspase 12 ELISA kit
E01C0690-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Human Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Pig Caspase 12 ELISA kit
E07C0690-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Porcine Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Pig Caspase 12 ELISA kit
E07C0690-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Porcine Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Pig Caspase 12 ELISA kit
E07C0690-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Porcine Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Human Caspase-12 ELISA Kit
EHC0697 96Tests
EUR 521
Goat Caspase-12 ELISA Kit
EGTC0697 96Tests
EUR 521
Dog Caspase 12 ELISA kit
E08C0690-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Canine Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Dog Caspase 12 ELISA kit
E08C0690-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Canine Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Dog Caspase 12 ELISA kit
E08C0690-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Canine Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Monkey Caspase 12 ELISA kit
E09C0690-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Monkey Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Monkey Caspase 12 ELISA kit
E09C0690-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Monkey Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Monkey Caspase 12 ELISA kit
E09C0690-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Monkey Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Canine Caspase-12 ELISA Kit
ECC0697 96Tests
EUR 521
Bovine Caspase-12 ELISA Kit
EBC0697 96Tests
EUR 521
Anserini Caspase-12 ELISA Kit
EAC0697 96Tests
EUR 521
Caspase 12 ELISA KIT|Human
EF008399 96 Tests
EUR 689
Porcine Caspase-12 ELISA Kit
EPC0697 96Tests
EUR 521
Rat Caspase-12 ELISA Kit
ERC0697 96Tests
EUR 521
Rabbit Caspase-12 ELISA Kit
ERTC0697 96Tests
EUR 521
Mouse Caspase-12 ELISA Kit
EMC0697 96Tests
EUR 521
Rat Caspase 12 (CASP12) Protein
20-abx065753
  • EUR 690.00
  • EUR 286.00
  • EUR 2124.00
  • EUR 815.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.
Mouse Caspase 12 (CASP12) Protein
20-abx167225
  • EUR 648.00
  • EUR 272.00
  • EUR 1998.00
  • EUR 773.00
  • EUR 467.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.
Caspase 12 (CASP12) Antibody (HRP)
20-abx316303
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
Caspase 12 (CASP12) Antibody (FITC)
20-abx316304
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
Caspase 12 (CASP12) Antibody (Biotin)
20-abx316305
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
Caspase 12 (Casp12) Antibody (HRP)
20-abx318990
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
Caspase 12 (Casp12) Antibody (FITC)
20-abx318991
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
Caspase 12 (Casp12) Antibody (Biotin)
20-abx318992
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
Caspase-12 Substrate ATAD-AFC
1117-1000
EUR 1088
Caspase-12 Substrate ATAD-AFC
1117-200
EUR 436
Caspase-12 Fluorometric Assay Kit
K139-100
EUR 501
Caspase-12 Fluorometric Assay Kit
K139-25
EUR 256
Caspase-12 Fluorometric Assay Kit
K2150-100 100 assays
EUR 529
Caspase-12 Fluorometric Assay Kit
K2150-25 25 assays
EUR 251
Anti-Caspase-12/CASP12 Antibody
PA2103 100ug/vial
EUR 334
Apelin-12 Peptide
20-abx266317
  • EUR 495.00
  • EUR 815.00
  • EUR 356.00
  • 10 mg
  • 25 mg
  • 5 mg
  • Shipped within 5-10 working days.
Individual Reaction Mix 12
G065-12 200 reactions
EUR 167
Human 12-lipoxygenase,LOX-12 ELISA Kit
201-12-0949 96 tests
EUR 440
  • This 12-lipoxygenase ELISA kit is validated to work with samples from whole blood, serum, plasma and cell culture supernatant.
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.
Human Caspase 12 (CASP12) ELISA Kit
abx513694-96tests 96 tests
EUR 707
  • Shipped within 5-12 working days.
Guinea pig Caspase 12 ELISA kit
E05C0690-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Guinea pig Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Guinea pig Caspase 12 ELISA kit
E05C0690-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Guinea pig Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Guinea pig Caspase 12 ELISA kit
E05C0690-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Guinea pig Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Mouse Casp12/ Caspase-12 ELISA Kit
E0211Mo 1 Kit
EUR 571
ELISA kit for Mouse Caspase-12
EK2112 96 tests
EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse Caspase-12 in samples from serum, plasma, tissue homogenates and other biological fluids.
ELISA kit for Human Caspase-12
EK2113 96 tests
EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Caspase-12 in samples from serum, plasma, tissue homogenates and other biological fluids.
ELISA kit for Rat Caspase-12
EK2114 96 tests
EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Rat Caspase-12 in samples from serum, plasma, tissue homogenates and other biological fluids.
Guinea Pig Caspase-12 ELISA Kit
EGC0697 96Tests
EUR 521
Human Caspase- 12, CASP12 ELISA KIT
ELI-02372h 96 Tests
EUR 824
Mouse Caspase- 12, Casp12 ELISA KIT
ELI-02373m 96 Tests
EUR 865
Mouse Caspase 12(CASP13)ELISA kit
GA-E0794MS-48T 48T
EUR 336
Mouse Caspase 12(CASP13)ELISA kit
GA-E0794MS-96T 96T
EUR 534
Rat Casp12(Caspase 12) ELISA Kit
ER0345 96T
EUR 567.6
  • Detection range: 0.156-10 ng/ml
  • Uniprot ID: Q920D5
  • Alias: Casp12/CASP-12/Caspase-12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 0.094 ng/ml
Mouse Casp12(Caspase-12) ELISA Kit
EM0436 96T
EUR 567.6
  • Detection range: 0.156-10 ng/ml
  • Uniprot ID: O08736
  • Alias: Casp12/CASP-12/Caspase-12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.094 ng/ml
Human Caspase 12 (CASP12) CLIA Kit
abx196504-96tests 96 tests
EUR 825
  • Shipped within 5-12 working days.
Human Caspase 12 (CASP12) ELISA Kit
20-abx259273
  • EUR 6642.00
  • EUR 3542.00
  • EUR 825.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests
  • Shipped within 5-12 working days.
Rat Caspase 12 (CASP12) ELISA Kit
abx353550-96tests 96 tests
EUR 786
  • Shipped within 5-12 working days.
Human Caspase 12 (CASP12) ELISA Kit
abx358592-96tests 96 tests
EUR 707
  • Shipped within 5-12 working days.
Mouse Caspase 12 (CASP12) CLIA Kit
20-abx491877
  • EUR 7973.00
  • EUR 4246.00
  • EUR 981.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests
  • Please enquire.
Rat Caspase 12 (CASP12) ELISA Kit
abx256323-96tests 96 tests
EUR 786
  • Shipped within 5-12 working days.
Mouse Caspase 12 (CASP12) ELISA Kit
20-abx258452
  • EUR 7378.00
  • EUR 3933.00
  • EUR 911.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests
  • Shipped within 5-7 working days.
Mouse Caspase 12 (CASP12) ELISA Kit
abx254790-96tests 96 tests
EUR 668
  • Shipped within 5-12 working days.
Rat Caspase 12 (CASP12) CLIA Kit
abx196787-96tests 96 tests
EUR 825
  • Shipped within 5-12 working days.
Caspase-12 Inhibitor Z-ATAD-FMK
1079-100
EUR 218
Caspase-12 Inhibitor Z-ATAD-FMK
1079-20C
EUR 218
CaspGLOW Active Caspase 12 Staining Kit
55R-1291 25 assays
EUR 282
Description: Caspase 12 Staining Kit for use activity in the research laboratory
Fluorescein Active Caspase-12 Staining Kit
K2046-25 25 assays
EUR 238
Rat Casp12/ Caspase-12 ELISA Kit
E0156Ra 1 Kit
EUR 571
Caspase 12 (CASP12) Polyclonal Antibody (Mouse)
4-PAA682Mu01
  • EUR 236.00
  • EUR 2338.00
  • EUR 586.00
  • EUR 294.00
  • EUR 209.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: CASP12 (Met1~Phe413)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12)
Conclusions: Calcium phosphate coatings stimulate cell proliferation at early levels of fracture restoration and apoptotic cell loss of life at later levels. Coating parts could present positional data guiding the differentiation of mesenchymal stromal cells. A change within the exercise of apoptotic elements, osteocalcin, and CD44 is brought on by gene induction in response to the diffusion of calcium phosphate compounds from coating to surrounding tissue.