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December 11, 2020

Copper nanoparticle-induced uterine injury in female rats.

By Dylan

Copper nanoparticles (Cu-NPs) have been used more and more in varied merchandise and functions. Though latest research have reported that publicity to Cu-NPs results in organ accumulation and apparent toxicity, it stays unclear whether or not Cu-NPs will be translocated to and trigger injury within the uterus. On this examine, we investigated the potential for uterine harm and gene expression patterns in feminine rats uncovered to three.12, 6.25, or 12.5 mg/kg/d Cu-NPs through intraperitoneal injection for <em>14</em> consecutive days. The outcomes indicated that publicity to Cu-NPs led to vital decreases within the relative uterine weight coefficients and will increase in inflammatory cell infiltration, mitochondrial swelling and vacuolization, shortened and lowered endometrial epithelial cell microvilli, and apoptosis.

Moreover, publicity to Cu-NPs elevated malondialdehyde (MDA) accumulation and decreased superoxide dismutase (SOD) ranges. Sign transduction mechanism research indicated that publicity to Cu-NPs activated <em>caspases</em> 3, 8, and 9 and BH3 interacting area dying agonist (tBid), lowered B cell leukemia/lymphoma 2 (Bcl-2) expression, and elevated the expression of apoptotic peptidase activating issue 1 (Apaf-1), BCL2-associated X, apoptosis regulator (Bax), and cytochrome c. A microarray evaluation revealed vital alterations within the expression of 963 genes; of those, 622 had been upregulated and 341 had been downregulated. The outcomes of additional evaluations of some altered genes, together with matrix metallopeptidase 12 (Mmp12), utilizing quantitative RT-PCR agreed with the microarray findings. These outcomes present sturdy proof that Cu-NPs can set off each intrinsic and extrinsic apoptotic pathways to mediate uterine harm, leading to oxidative stress-related modifications in gene expression.

Beforehand, we confirmed that noxious stimulation of the tail produces quite a few detrimental results after spinal wire harm (SCI), together with an earlier onset and elevated magnitude of mechanical hypersensitivity. Increasing on these observations, this examine sought to find out whether or not localized peripheral irritation equally impacts the expression of mechanical hypersensitivity after SCI.

 

The Impact of Lengthy-Time period Administration of Fatty Acid Amide Hydrolase Inhibitor URB597 on Oxidative Metabolism within the Coronary heart of Rats with Main and Secondary Hypertension.

 

Fatty acid amide hydrolase (FAAH) inhibitor [3-(3-carbamoylphenyl)phenyl] N-cyclohexylcarbamate (URB597) might affect redox stability and blood stress by means of the modulation of endocannabinoids ranges. Due to this fact, this examine aimed to check modifications in oxidative metabolism and apoptosis within the hearts of rats with spontaneous hypertension (SHR) and secondary hypertension (11-deoxycorticosterone acetate; DOCA-salt rats) handled by URB597 through intraperitoneal injection for days. The outcomes confirmed that URB597 decreased the exercise of NADPH and xanthine oxidases in each teams of rats. Furthermore, within the coronary heart of SHR rats, URB597 led to a rise of enzymatic and nonenzymatic antioxidant exercise and ranges (catalase, vitamin C, glutathione/glutathione disulfide [GSH/GSSG]) and upregulation of the thioredoxin system; nonetheless, NRf2 expression was downregulated.

The alternative impact in relation to Nrf2 exercise and the thioredoxin system was noticed in DOCA-salt rats after URB597 administration. Regardless of enchancment in antioxidant parameters, URB597 enhanced oxidative modifications of phospholipids (4-hydroxynonenal and isoprostanes) and proteins (carbonyl teams) in SHR coronary heart, whereas 4-hydroxynonenal and carbonyl teams ranges decreased within the coronary heart of DOCA-salt rats. Obtained outcomes recommend that examined lipid mediators are concerned in peroxisome proliferator-activated receptors (PPAR)-independent and PPAR-dependent modulation of cardiac inflammatory reactions. Moreover, decreased expression of pro-apoptotic proteins (Bax and <em>caspase</em> Three and 9) was noticed after URB597 administration within the coronary heart of each teams of hypertensive rats, whereas expression of the antiapoptotic protein (Bcl-2) elevated in SHR rats.

Lengthy-term administration of URB597 altered cardiac redox standing relying on the kind of hypertension. URB597 enhanced oxidative metabolism and lowered pro-apoptotic components within the coronary heart of SHR rats, rising the chance of coronary heart metabolic issues prevalence or development.

 

Self-nanoemulsifying drug-delivery programs for potentiated anti-inflammatory exercise of diacerein.

UNASSIGNED
Efficient therapy of osteoarthritis necessitates each symptomatic aid and hindrance of joint degeneration development. Non-steroidal anti-inflammatory medicine allow symptomatic aid solely and might trigger mucosal harm within the intestine. Earlier than absorption, diacerein (Dcn) is transformed into rhein that counteracts cartilage degeneration with out affecting prostaglandin manufacturing. But, low solubility and laxative motion of unabsorbed rhein within the colon hindered its use. Thus, enhanced Dcn dissolution would enable absorption on the higher intestine bettering its bioavailability and probably abolishing the laxative motion.
UNASSIGNED
Due to this fact, self-nanoemulsifying drug supply programs (SNEDDSs) with every of gelucire (Glc) and d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) at totally different drug:service weight ratios of 1:1, 1:2, 1:4, 1:6, 1:Eight and 1:10 had been ready by soften methodology and crammed into arduous gelatin capsules. The optimized binary programs had been chosen primarily based on strong state characterization, scanning electron microscopy (SEM) and in vitro analysis of the ready SNEDDSs as compared with their corresponding bodily mixtures (PMs) and Dcn. The optimized programs had been additional examined with respect to their morphology, measurement distribution and ζ-potential. Furthermore, the anti-inflammatory exercise of the optimized programs towards carrageenan-induced paw edema in rats was assessed by means of estimation of edema and edema inhibition percentages in addition to histopathological examination and immunohistochemical localization of tumor necrosis factor-alpha (TNF-α) and <em>caspase</em>-3.
UNASSIGNED
Considerably (P<0.05) enhanced in vitro drug launch was recorded for SNEDDSs with both service when in comparison with Dcn and the corresponding PMs. SNEDDSs primarily based on 1:10 Dcn:Glc and 1:Eight Dcn:TPGS confirmed considerably (P<0.05) lowered edema and irritation in addition to expression of TNF-α and caspase-Three relative to constructive management and Dcn pretreated teams.

FAM FLICA CASPASE-1 KIT (OKSA11275)
OKSA11275 100 Tests
EUR 1827.6
Description: Description of target: The FAM FLICATM Capase 1 kit uses a target sequence (YVAD) sandwiched between a green fluorescent label, FAM, and FMK to make a quick and flexible method to analyze active capases in apoptotic cells. These kits measure apoptosis by detecting active caspases in whole, living cells. They don't work by using antibodies or an ELISA. Instead, their methodology is based a unique cell-permeable and non-cytotoxic reagent called Fluorochrome Inhibitor of Caspases. These kits are suitable for cells in suspension, adherent cells, thin tissue sections (but not fixed or paraffin-embedded cells) from many species including mammalian, insect, and yeast. Different cell types, e.g. HeLa, primary neurons, macrophages and lymphocytes have also been successfully studied with these kits. ;Species reactivity: Human;Application: FC, IF;Assay info: ;Sensitivity:

FAM FLICA CASPASE-2 KIT (OKSA11283)
OKSA11283 100 Tests
EUR 1593.6
Description: Description of target: FAM FLICAâ„¢ CASPASE-2 KIT;Species reactivity: ;Application: FC, IF;Assay info: ;Sensitivity:

FAM FLICA CASPASE-3/7 KIT (OKSA11271)
OKSA11271 100 Tests
EUR 1828.8
Description: Description of target: The FAM FLICA™ Caspase 3 & 7 kit uses a quick and easy method to analyze active caspases in apoptotic cells.;Species reactivity: ;Application: FC, IF;Assay info: ;Sensitivity:

FAM FLICAâ„¢ CASPASE-9 KIT (OKSA11278)
OKSA11278 25 Tests
EUR 709.2
Description: Description of target: FAM FLICAâ„¢ CASPASE-9 KIT;Species reactivity: ;Application: FC, IF;Assay info: ;Sensitivity:

FAM FLICAâ„¢ CASPASE-9 KIT (OKSA11279)
OKSA11279 100 Tests
EUR 1828.8
Description: Description of target: FAM FLICAâ„¢ CASPASE-9 KIT;Species reactivity: ;Application: FC, IF;Assay info: ;Sensitivity:

FAM FLICAâ„¢ CASPASE-6 KIT (OKSA11272)
OKSA11272 25 Tests
EUR 717.6
Description: Description of target: FAM FLICAâ„¢ CASPASE-6 KIT;Species reactivity: ;Application: FC, IF;Assay info: ;Sensitivity:

FAM FLICAâ„¢ CASPASE-6 KIT (OKSA11273)
OKSA11273 100 Tests
EUR 1860
Description: Description of target: FAM FLICAâ„¢ CASPASE-6 KIT;Species reactivity: ;Application: FC, IF;Assay info: ;Sensitivity:

FAM FLICAâ„¢ CASPASE-8 KIT (OKSA11276)
OKSA11276 25 Tests
EUR 709.2
Description: Description of target: FAM FLICAâ„¢ CASPASE-8 KIT;Species reactivity: ;Application: FC, IF;Assay info: ;Sensitivity:

FAM FLICAâ„¢ CASPASE-8 KIT (OKSA11277)
OKSA11277 100 Tests
EUR 1828.8
Description: Description of target: FAM FLICAâ„¢ CASPASE-8 KIT;Species reactivity: ;Application: FC, IF;Assay info: ;Sensitivity:

FAM FLICAâ„¢ CASPASE-2 KIT (OKSA11282)
OKSA11282 25 Tests
EUR 668.4
Description: Description of target: FAM FLICAâ„¢ CASPASE-2 KIT;Species reactivity: ;Application: FC, IF;Assay info: ;Sensitivity:

FAM FLICAâ„¢ POLY CASPASE KIT (OKSA11268)
OKSA11268 25 Tests
EUR 709.2
Description: Description of target: FAM FLICAâ„¢ POLY CASPASE KIT;Species reactivity: ;Application: FC, IF;Assay info: ;Sensitivity:

FAM FLICAâ„¢ POLY CASPASE KIT (OKSA11269)
OKSA11269 100 Tests
EUR 1828.8
Description: Description of target: FAM FLICAâ„¢ POLY CASPASE KIT;Species reactivity: ;Application: FC, IF;Assay info: ;Sensitivity:

SR FLICAâ„¢ CASPASE-9 KIT (OKSA11301)
OKSA11301 25 Tests
EUR 724.8
Description: Description of target: SR FLICAâ„¢ CASPASE-9 KIT;Species reactivity: ;Application: FC, IF;Assay info: ;Sensitivity:

SR FLICAâ„¢ CASPASE-9 KIT (OKSA11302)
OKSA11302 100 Tests
EUR 1884
Description: Description of target: SR FLICAâ„¢ CASPASE-9 KIT;Species reactivity: ;Application: FC, IF;Assay info: ;Sensitivity:

SR FLICAâ„¢ POLY CASPASE KIT (OKSA11280)
OKSA11280 25 Tests
EUR 756
Description: Description of target: SR FLICAâ„¢ POLY CASPASE KIT;Species reactivity: ;Application: FC, IF;Assay info: ;Sensitivity:

SR FLICAâ„¢ POLY CASPASE KIT (OKSA11281)
OKSA11281 100 Tests
EUR 1828.8
Description: Description of target: SR FLICAâ„¢ POLY CASPASE KIT;Species reactivity: ;Application: FC, IF;Assay info: ;Sensitivity:

Caspase-9
GT15045 100 ul
EUR 600

Caspase 9 Assay Kit
20-abx299021
  • EUR 1562.40
  • EUR 698.40
  • 100 tests
  • 25 tests

Caspase 9 Assay Kit
20-abx299035
  • EUR 1562.40
  • EUR 698.40
  • 100 tests
  • 25 tests

Rat Caspase-9,Casp-9 ELISA Kit
CN-01708R1 96T
EUR 542.4

Rat Caspase-9,Casp-9 ELISA Kit
CN-01708R2 48T
EUR 362.4

Rat Caspase-9, Casp-9 ELISA Kit
CSB-E08863r-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Rat Caspase-9, Casp-9 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Rat Caspase-9, Casp-9 ELISA Kit
1-CSB-E08863r
  • EUR 843.60
  • EUR 5811.60
  • EUR 3084.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Rat Caspase-9, Casp-9 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Caspase-9,Casp-9 ELISA Kit
CN-02586M1 96T
EUR 525.6

Mouse Caspase-9,Casp-9 ELISA Kit
CN-02586M2 48T
EUR 346.8

Human Caspase-9,Casp-9 ELISA Kit
CN-03799H1 96T
EUR 576

Human Caspase-9,Casp-9 ELISA Kit
CN-03799H2 48T
EUR 397.2

Human Caspase-9, Casp-9 ELISA Kit
CSB-E08862h-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human Caspase-9, Casp-9 in samples from serum, plasma, tissue homogenates, cell lysates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Caspase-9, Casp-9 ELISA Kit
1-CSB-E08862h
  • EUR 843.60
  • EUR 5811.60
  • EUR 3084.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Caspase-9, Casp-9 in samples from serum, plasma, tissue homogenates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Caspase-9, Casp-9 ELISA Kit
CSB-E08864m-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Mouse Caspase-9, Casp-9 in samples from serum, plasma, tissue homogenates, cell lysates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse Caspase-9, Casp-9 ELISA Kit
1-CSB-E08864m
  • EUR 843.60
  • EUR 5811.60
  • EUR 3084.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Mouse Caspase-9, Casp-9 in samples from serum, plasma, tissue homogenates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Rat caspase-9 ELISA Kit
ERC0103 96Tests
EUR 625.2

Goat Caspase-9 ELISA Kit
EGTC0103 96Tests
EUR 625.2

FAM FLICACASPASE-3/7 KIT (OKSA11270)
OKSA11270 25 Tests
EUR 709.2
Description: Description of target:

Caspase FLICA™ kits measure apoptosis by detecting active caspases in whole, living cells. These kits do not work by using antibodies or as an ELISA. Instead, their methodology is based on a unique cell-permeable and non-cytotoxic reagent called the Fluorochrome Inhibitor of Caspases (FLICA). The FLICA™ reagent contains a caspase inhibitor sequence linked to a green (Carboxyfluorescein, FAM) fluorescent probe.


The Caspase FLICA™ Kits are suitable for cells in suspension, adherent cells, thin tissue sections (but not fixed or paraffin-embedded cells) from many species including mammalian, insect and yeast. Different cell types, e.g. HeLa, primary neurons, macrophages and lymphocytes have also been successfully studied with these kits.


This kit can be used with a flow cytometer, fluorescence microscope or a fluorescence plate reader using black microtitre plates.

;Species reactivity: ;Application: FC, IF;Assay info: ;Sensitivity:

Mouse caspase-9 ELISA Kit
EMC0103 96Tests
EUR 625.2

Caspase-9 (Human) ELISA Kit
K4165-100 each
EUR 966

Sheep Caspase-9 ELISA Kit
ESC0103 96Tests
EUR 625.2

Human Caspase-9 ELISA Kit
EHC0103 96Tests
EUR 625.2

Mouse Caspase-9 ELISA Kit
GA-E0640MS-48T 48T
EUR 403.2

Mouse Caspase-9 ELISA Kit
GA-E0640MS-96T 96T
EUR 640.8

Rat Caspase 9(Casp-9) ELISA Kit
QY-E11899 96T
EUR 448.8

Monkey Caspase-9 ELISA Kit
EMKC0103 96Tests
EUR 625.2

Bovine Caspase-9 ELISA Kit
EBC0103 96Tests
EUR 625.2

Rabbit Caspase-9 ELISA Kit
ERTC0103 96Tests
EUR 625.2

Canine Caspase-9 ELISA Kit
ECC0103 96Tests
EUR 625.2

Porcine Caspase-9 ELISA Kit
EPC0103 96Tests
EUR 625.2

Chicken Caspase-9 ELISA Kit
ECKC0103 96Tests
EUR 625.2

Rat Caspase 9 ELISA kit
E02C0096-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rat Caspase 9 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Caspase 9 ELISA kit
E02C0096-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Rat Caspase 9 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Caspase 9 ELISA kit
E02C0096-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Rat Caspase 9 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Caspase 9 Assay Kit, red
KF17302 25 Tests
EUR 364.8

Dog Caspase 9 ELISA kit
E08C0096-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Canine Caspase 9 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Caspase 9 ELISA kit
E08C0096-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Canine Caspase 9 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Caspase 9 ELISA kit
E08C0096-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Canine Caspase 9 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Caspase 9 ELISA kit
E07C0096-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Porcine Caspase 9 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Caspase 9 ELISA kit
E07C0096-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Porcine Caspase 9 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Caspase 9 ELISA kit
E07C0096-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Porcine Caspase 9 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Caspase-9 Peptide
2071P 0.05 mg
EUR 197.7
Description: (IN1) Caspase-9 peptide

Caspase-9 Peptide
2073P 0.05 mg
EUR 197.7
Description: (IN2) Caspase-9 peptide

Caspase-9 Antibody
6670-100 each
EUR 405.6

Caspase-9 Antibody
6670-30T each
EUR 175.2

Caspase-9 Antibody
48161-100ul 100ul
EUR 399.6

Caspase-9 Antibody
48161-50ul 50ul
EUR 286.8

Caspase-9 Antibody
48687-100ul 100ul
EUR 399.6

Caspase-9 Antibody
48687-50ul 50ul
EUR 286.8

Caspase-9 Antibody
49014-100ul 100ul
EUR 399.6

Caspase-9 Antibody
49014-50ul 50ul
EUR 286.8

Caspase-9 Antibody
24049-100ul 100ul
EUR 468

Caspase-9 Antibody
24050-100ul 100ul
EUR 468

Caspase-9 Antibody
2071-002mg 0.02 mg
EUR 206.18
Description: Caspase-9 Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. A novel member in the caspase family was recently identified and designated ICE-LAP6, Mch6, and Apaf-3. Caspase-9 and Apaf-1 bind to each other, which leads to caspase-9 activation. Caspase-9 is also activated by granzyme B and CPP32. Activated caspase-9 cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. Caspase-9 play a central role in cell death induced by a wide variety of apoptosis activators including TNFα, TRAIL, anti-CD-95, FADD, and TRADD. Caspase-9 is expressed in a variety of human tissues.

Caspase-9 Antibody
2071-01mg 0.1 mg
EUR 523.7
Description: Caspase-9 Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. A novel member in the caspase family was recently identified and designated ICE-LAP6, Mch6, and Apaf-3. Caspase-9 and Apaf-1 bind to each other, which leads to caspase-9 activation. Caspase-9 is also activated by granzyme B and CPP32. Activated caspase-9 cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. Caspase-9 play a central role in cell death induced by a wide variety of apoptosis activators including TNFα, TRAIL, anti-CD-95, FADD, and TRADD. Caspase-9 is expressed in a variety of human tissues.

Caspase-9 Antibody
2073-002mg 0.02 mg
EUR 206.18
Description: Caspase-9 Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. A novel member in the caspase family was recently identified and designated ICE-LAP6, Mch6, and Apaf-3. Caspase-9 and Apaf-1 bind to each other, which leads to caspase-9 activation. Caspase-9 is also activated by granzyme B and CPP32. Activated caspase-9 cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. Caspase-9 play a central role in cell death induced by a wide variety of apoptosis activators including TNFα, TRAIL, anti-CD-95, FADD, and TRADD. Caspase-9 is expressed in a variety of human tissues.

Caspase-9 Antibody
2073-01mg 0.1 mg
EUR 523.7
Description: Caspase-9 Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. A novel member in the caspase family was recently identified and designated ICE-LAP6, Mch6, and Apaf-3. Caspase-9 and Apaf-1 bind to each other, which leads to caspase-9 activation. Caspase-9 is also activated by granzyme B and CPP32. Activated caspase-9 cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. Caspase-9 play a central role in cell death induced by a wide variety of apoptosis activators including TNFα, TRAIL, anti-CD-95, FADD, and TRADD. Caspase-9 is expressed in a variety of human tissues.

Caspase-9 Antibody
3016-100 each
EUR 405.6

Caspase-9 Antibody
3016-30T each
EUR 175.2

Caspase-9 Antibody
3136-100 each
EUR 392.4

Caspase-9 Antibody
3136-30T each
EUR 175.2

Caspase-9 Antibody
3409-100 each
EUR 379.2

Caspase-9 Antibody
3409-30T each
EUR 175.2

Caspase-9 Antibody
F50929-0.08ML 0.08 ml
EUR 140.25
Description: Caspase 9 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1; this step is thought to be one of the earliest in the caspase activation cascade.

Caspase-9 Antibody
F50929-0.4ML 0.4 ml
EUR 322.15
Description: Caspase 9 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1; this step is thought to be one of the earliest in the caspase activation cascade.

Caspase-9 Antibody
F50930-0.08ML 0.08 ml
EUR 140.25
Description: Caspase 9 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1; this step is thought to be one of the earliest in the caspase activation cascade.

Caspase-9 Antibody
F50930-0.4ML 0.4 ml
EUR 322.15
Description: Caspase 9 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1; this step is thought to be one of the earliest in the caspase activation cascade.

Caspase-9 Antibody
RQ6459 100ug
EUR 356.15
Description: CASP9 is also known as MCH6 or APAF3. This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.

Caspase-9 Antibody
RQ6974 100 ug
EUR 356.15
Description: CASP9 is also known as MCH6 or APAF3. This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.

Caspase-9 Antibody
R31745 100 ug
EUR 356.15
Description: Caspase-9 is also known as MCH6 or APAF3. The CASP9 gene encodes a member of the cysteine-aspartic acid protease family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex ofCytochrome Cand the Apoptotic peptidase activating factor 1. This step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.

Caspase-9 Antibody
R30673 100 ug
EUR 356.15
Description: Caspase-9, also called APAF3, is an initiator caspase, encoded by the CASP9 gene. The gene is mapped to chromosome 1p36.3-p36.1 by FISH. CASP9 is identified as a member of the caspase family that participates in CASP3 activation in vitro. And it also regarded as the most upstream member of the apoptotic protease cascade that is triggered by Cytochrome C and dATP. The crystal structure of CASP9 is complex with the BIR3 in an inhibitory domain of XIAP at 2.4-angstrom resolution and the gene contains 9 exons and spans approximately 35 kb of genomic DNA. Caspase-9 and APAF1 bind to each other via their respective NH2-terminal CED-3 homologous domains in the presence of Cytochrome C and dATP, an event that leads to CASP9 activation. Activity increases dramatically upon association with the apoptosome complex. And the majority of CASP9 knockout mice died perinatally with a markedly enlarged and malformed cerebrum caused by reduced apoptosis during brain development.

Goat Caspase 9 ELISA kit
E06C0096-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Goat Caspase 9 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Caspase 9 ELISA kit
E06C0096-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Goat Caspase 9 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Caspase 9 ELISA kit
E06C0096-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Goat Caspase 9 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Caspase 9 Cell ELISA Kit
abx595093-96tests 96 tests
EUR 764.4

Human Caspase 9 ELISA kit
55R-IB49680 96 wells
EUR 1413.6
Description: ELISA kit for the detection of Caspase 9 in the research laboratory

Human Caspase 9 ELISA kit
E01C0096-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Human Caspase 9 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Caspase 9 ELISA kit
E01C0096-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Human Caspase 9 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Caspase 9 ELISA kit
E01C0096-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Human Caspase 9 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Caspase 9 ELISA kit
E03C0096-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Mouse Caspase 9 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Caspase 9 ELISA kit
E03C0096-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Mouse Caspase 9 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Caspase 9 ELISA kit
E03C0096-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Mouse Caspase 9 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Caspase 9 Assay Kit, green
KF17206 25 Tests
EUR 364.8

Caspase 9 ELISA KIT|Human
EF008403 96 Tests
EUR 826.8

Caspase-9 Colorimetric Assay Kit
K119-100 each
EUR 588

Caspase-9 Colorimetric Assay Kit
K119-200 each
EUR 744

Caspase-9 Colorimetric Assay Kit
K119-25 each
EUR 261.6

Caspase-9 Colorimetric Assay Kit
K119-400 each
EUR 1149.6

Caspase-9 Fluorometric Assay Kit
K118-100 each
EUR 561.6

Caspase-9 Fluorometric Assay Kit
K118-200 each
EUR 738

Caspase-9 Fluorometric Assay Kit
K118-25 each
EUR 248.4

Caspase-9 Fluorometric Assay Kit
K118-400 each
EUR 1149.6

Caspase-9 Fluorometric Assay Kit
K2018-100 100 assays
EUR 602.4

Caspase-9 Fluorometric Assay Kit
K2018-200 200 assays
EUR 802.8

Caspase-9 Fluorometric Assay Kit
K2018-25 25 assays
EUR 285.6

Caspase-9 Fluorometric Assay Kit
K2018-400 400 assays
EUR 1336.8

Caspase-9 Colorimetric Assay Kit
K2019-100 100 assays
EUR 634.8

Caspase-9 Colorimetric Assay Kit
K2019-200 200 assays
EUR 835.2

Caspase-9 Colorimetric Assay Kit
K2019-25 25 assays
EUR 301.2

Caspase-9 Colorimetric Assay Kit
K2019-400 400 assays
EUR 1387.2

Rabbit Caspase 9 ELISA kit
E04C0096-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rabbit Caspase 9 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Caspase 9 ELISA kit
E04C0096-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Rabbit Caspase 9 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Caspase 9 ELISA kit
E04C0096-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Rabbit Caspase 9 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Caspase 9 ELISA kit
E09C0096-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Monkey Caspase 9 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Caspase 9 ELISA kit
E09C0096-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Monkey Caspase 9 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Caspase 9 ELISA kit
E09C0096-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Monkey Caspase 9 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Caspase 9 protein
30R-2406 25 units
EUR 450
Description: Purified recombinant Human Caspase 9 protein

Caspase 9 protein
30R-2407 50 ug
EUR 697.2
Description: Purified recombinant Human Caspase 9 protein

Mouse CASP9(Caspase-9) ELISA Kit
EM0901 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.094 ng/ml

Human CASP9/ Caspase-9 ELISA Kit
E0363Hu 1 Kit
EUR 675.6

Human CASP9(Caspase-9) ELISA Kit
EH0650 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.938 ng/ml

CLIA kit for Human CASP 9 (Caspase 9)
E-CL-H0504 1 plate of 96 wells
EUR 700.8
Description: A sandwich CLIA kit for quantitative measurement of Human CASP 9 (Caspase 9) in samples from Serum, Plasma, Cell supernatant

Caspase 9 antibody
70R-11636 100 ug
EUR 501.6
Description: Rabbit polyclonal Caspase 9 antibody

Caspase 9 antibody
70R-11806 100 ug
EUR 483.6
Description: Rabbit polyclonal Caspase 9 antibody

Caspase 9 antibody
70R-13511 100 ul
EUR 548.4
Description: Affinity purified Rabbit polyclonal Caspase 9 antibody

Caspase 9 antibody
70R-14132 100 ug
EUR 386.4
Description: Affinity purified Rabbit polyclonal Caspase 9 antibody

Caspase 9 antibody
70R-30659 100 ug
EUR 392.4
Description: Rabbit polyclonal Caspase 9 antibody

Caspase 9 Antibody
21422-100ul 100ul
EUR 302.4

Caspase 9 Antibody
21422-50ul 50ul
EUR 224.4
UNASSIGNED
These SNEDDSs will be represented as potential oral drug supply programs of Dcn for enhanced dissolution and anti inflammatory exercise towards carrageenan-induced paw edema.
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