Cardiomyocyte irritation adopted by apoptosis and fibrosis is a crucial mediator for growth and development of coronary heart failure. Activation of toll-like receptor 4 (TLR4), an necessary regulator of irritation, causes the development of cardiac hypertrophy and harm. Nevertheless, the exact mechanism of TLR4-mediated antagonistic cardiac outcomes remains to be elusive. The current research was designed to seek out the function of TLR4 in cardiac fibrosis and apoptosis, and molecular mechanism thereof. Rats have been handled with TLR4 agonist (LPS 12.5 μg/kg/day) via osmotic pump for <em>14</em> days. To simulate the situation in vitro, H9c2 cells have been handled with LPS (1 μg/ml). Equally, H9c2 cells have been transfected with TLR4 and SIRT2 c-DNA clone for overexpression. Myocardial oxidative stress, irritation, fibrosis and mitochondrial parameters have been evaluated each in vitro and in vivo. Cardiac irritation after LPS therapy was confirmed by elevated TNF-α and IL-6 expression in rat coronary heart.
There was a marked improve in oxidative stress as noticed by elevated TBARS and decreased endogenous antioxidants (GSH and catalase), together with mitochondrial dysfunction as measured by mitochondrial complicated exercise in LPS-treated rat hearts. Histopathological examination confirmed the presence of cardiac fibrosis after LPS therapy. Protein expression of nuclear p53 and cleaved <em>caspase</em>-7/<em>caspase</em>-9 was considerably elevated in LPS handled coronary heart. Just like in vivo research, nuclear translocation of p53, mitochondrial dysfunction and mobile apoptosis have been noticed in H9c2 cells handled with LPS. Our knowledge additionally point out that decreased expression of SIRT2 was related to elevated acetylation of p53 after LPS therapy. In conclusion, TLR4 activation in rats promotes cardiac irritation, mitochondrial dysfunction, apoptosis and fibrosis. p53 and <em>caspase</em> 7/<em>caspase</em> 9 have been discovered to play an necessary function in TLR4-mediated apoptosis.
Our knowledge counsel that, lowering TLR4 mediated fibrosis and apoptosis may very well be a novel method within the therapy of coronary heart failure, retaining within the view the main function performed by TLR4 in cardiac irritation. BACKGROUND Cardiac distant ischemic conditioning (RIC) is a noninvasive cardioprotective methodology in ischemia-reperfusion harm and acute myocardial infarction (AMI). The goals of this research have been to analyze the results of RIC in a rat mannequin of AMI. MATERIAL AND METHODS Grownup male Sprague-Dawley rats included the AMI group that underwent ligation of the left anterior descending (LAD) coronary artery (n=24), the RIC group that consisted the AMI rat mannequin handled with RIC as soon as each day within the left hind limb till days 1, 7 and <em>14</em> (n=24), and the sham group (n=24). Myocardial infarct measurement was measured by routine histology with triphenyltetrazolium chloride (TTC) and Masson’s trichrome histochemical staining for myocardial necrosis and fibrosis, respectively.
Mitochondrial defect in muscle precedes neuromuscular junction degeneration and motor neuron dying in CHCHD10S59L/+ mouse.
Lately, we offered genetic foundation exhibiting that mitochondrial dysfunction can set off motor neuron degeneration, via identification of CHCHD10 encoding a mitochondrial protein. We reported sufferers, carrying the p.Ser59Leu heterozygous mutation in CHCHD10, from a big household with a mitochondrial myopathy related to motor neuron illness (MND). Quickly, our group and others reported CHCHD10 mutations in amyotrophic lateral sclerosis (ALS), frontotemporal dementia-ALS and different neurodegenerative illnesses. Right here, we generated knock-in (KI) mice, carrying the p.Ser59Leu mutation, that mimic the mitochondrial myopathy with mtDNA instability displayed by the sufferers from our authentic household. Earlier than months of age, all KI mice developed a deadly mitochondrial cardiomyopathy related to enhanced mitophagy.
mice additionally displayed neuromuscular junction (NMJ) and motor neuron degeneration with hyper-fragmentation of the motor finish plate and average however vital motor neuron loss in lumbar spinal twine on the finish stage of the illness. At this stage, we noticed TDP-43 cytoplasmic aggregates in spinal neurons. We additionally confirmed that motor neurons differentiated from human iPSC carrying the p.Ser59Leu mutation have been way more delicate to Staurosporine or glutamate-induced <em>caspase</em> activation than management cells. These knowledge verify that mitochondrial deficiency related to CHCHD10 mutations may be on the origin of MND. CHCHD10 is extremely expressed within the NMJ post-synaptic half. Importantly, the fragmentation of the motor finish plate was related to irregular CHCHD10 expression that was additionally noticed closed to NMJs which have been morphologically regular.
Moreover, we discovered OXPHOS deficiency in muscle of CHCHD10 mice at Three months of age within the absence of neuron loss in spinal twine. Our knowledge present that the pathological results of the p.Ser59Leu mutation goal muscle previous to NMJ and motor neurons. They seemingly result in OXPHOS deficiency, lack of cristae junctions and destabilization of inside membrane construction inside mitochondria at motor finish plate of NMJ, impairing neurotransmission. These knowledge are in favor with a key function for muscle in MND related to CHCHD10 mutations.
Activation of toll like receptor 4 (TLR4) promotes cardiomyocyte apoptosis through SIRT2 dependent p53 deacetylation
Manganese suppresses oxidative stress, irritation and caspase-Three activation in rats uncovered to chlorpyrifos.
The current research investigated the person and mixed impression of organophosphorus pesticide chlorpyrifos (CPF) and manganese (Mn), a naturally occurring hint steel, on hepatorenal perform in grownup rats. The 4 experimental teams particularly management, CPF alone (5 mg/kg), Mn alone (10 mg/kg) and the co-exposure group consisted of eight rats which have been orally gavage for <em>14</em> consecutive days. Following sacrifice, the biomarkers of hepatorenal injury, antioxidant enzyme actions, myeloperoxidase (MPO) exercise in addition to ranges of nitric oxide, reactive oxygen and nitrogen (RONS) species and lipid peroxidation (LPO) have been analysed spectrophotometrically.
Additional, the focus of tumour necrosis issue alpha (TNF-α), interleukin-1 β (IL-1β) and <em>caspase</em>-Three exercise have been assessed utilizing ELISA. Outcomes confirmed that the CPF-induced improve in biomarkers of hepatorenal toxicity have been considerably (p < 0.05) alleviated in rats co-expose to CPF and Mn. Furthermore, the lower in antioxidant standing in addition to the elevation in RONS and LPO have been considerably assuaged in rats co-treated with CPF and Mn. As well as, CPF mediated improve in TNF-α, IL-1β and <em>caspase</em>-Three exercise have been considerably diminished within the liver and kidney of rats co-exposed to CPF and Mn.
anti- Caspase 12 antibody |
FNab01286 |
FN Test |
100µg |
EUR 606.3 |
|
Description: Antibody raised against Caspase 12 |
anti- Caspase 2 antibody |
FNab01287 |
FN Test |
100µg |
EUR 606.3 |
|
Description: Antibody raised against Caspase 2 |
anti- Caspase 2 antibody |
FNab01288 |
FN Test |
100µg |
EUR 658.5 |
|
Description: Antibody raised against Caspase 2 |
anti- Caspase 3 antibody |
FNab01289 |
FN Test |
100µg |
EUR 606.3 |
|
Description: Antibody raised against Caspase 3 |
anti- Caspase 4 antibody |
FNab01291 |
FN Test |
100µg |
EUR 606.3 |
|
Description: Antibody raised against Caspase 4 |
anti- Caspase 6 antibody |
FNab01292 |
FN Test |
100µg |
EUR 658.5 |
|
Description: Antibody raised against Caspase 6 |
anti- Caspase 8 antibody |
FNab01293 |
FN Test |
100µg |
EUR 606.3 |
|
Description: Antibody raised against Caspase 8 |
anti- Caspase 8 antibody |
FNab01294 |
FN Test |
100µg |
EUR 606.3 |
|
Description: Antibody raised against Caspase 8 |
anti- Caspase 9 antibody |
FNab01295 |
FN Test |
100µg |
EUR 606.3 |
|
Description: Antibody raised against Caspase 9 |
anti- Caspase 9 antibody |
FNab01296 |
FN Test |
100µg |
EUR 606.3 |
|
Description: Antibody raised against Caspase 9 |
anti- Caspase 9 antibody |
FNab01297 |
FN Test |
100µg |
EUR 658.5 |
|
Description: Antibody raised against Caspase 9 |
Caspase 1 Antibody |
6687-100 |
Biovision |
each |
EUR 405.6 |
Caspase 1 Antibody |
6687-30T |
Biovision |
each |
EUR 175.2 |
Caspase 1 antibody |
20R-1427 |
Fitzgerald |
100 ug |
EUR 781.2 |
Description: Rabbit polyclonal Caspase 1 antibody |
caspase 1 Antibody |
39310-100ul |
SAB |
100ul |
EUR 468 |
Caspase 1 Antibody |
E18-5418-1 |
EnoGene |
50μg/50μl |
EUR 145 |
Description: Available in various conjugation types. |
Caspase 1 Antibody |
E18-5418-2 |
EnoGene |
100μg/100μl |
EUR 225 |
Description: Available in various conjugation types. |
Caspase 1 Antibody |
DF6148 |
Affbiotech |
200ul |
EUR 420 |
Caspase 1 Antibody |
E38PA5426 |
EnoGene |
100ul |
EUR 225 |
Description: Available in various conjugation types. |
Caspase 1 Antibody |
E38PA1133 |
EnoGene |
100ul |
EUR 225 |
Description: Available in various conjugation types. |
caspase 1 Antibody |
E300022a |
EnoGene |
100ug/200ul |
EUR 275 |
Description: Available in various conjugation types. |
caspase 1 Antibody |
E300022b |
EnoGene |
200ul |
EUR 275 |
Description: Available in various conjugation types. |
Caspase 1 antibody |
70R-13979 |
Fitzgerald |
100 ug |
EUR 519 |
|
Description: Affinity purified Rabbit polyclonal Caspase 1 antibody |
Caspase 1 antibody |
70R-14061 |
Fitzgerald |
100 ug |
EUR 519 |
|
Description: Affinity purified Rabbit polyclonal Caspase 1 antibody |
Caspase 1 antibody |
70R-15367 |
Fitzgerald |
100 ug |
EUR 302 |
|
Description: Rabbit polyclonal Caspase 1 antibody |
Caspase 1 antibody |
70R-11561 |
Fitzgerald |
100 ug |
EUR 490 |
|
Description: Rabbit polyclonal Caspase 1 antibody |
Caspase 1 antibody |
70R-31086 |
Fitzgerald |
100 ug |
EUR 294 |
|
Description: Rabbit polyclonal Caspase 1 antibody |
Caspase 1 antibody |
70R-31087 |
Fitzgerald |
100 ug |
EUR 294 |
|
Description: Rabbit polyclonal Caspase 1 antibody |
Caspase 1 antibody |
70R-31116 |
Fitzgerald |
100 ug |
EUR 294 |
|
Description: Rabbit polyclonal Caspase 1 antibody |
Caspase 1 antibody |
70R-35920 |
Fitzgerald |
100 ug |
EUR 294 |
|
Description: Rabbit polyclonal Caspase 1 antibody |
Caspase 1 antibody |
70R-49451 |
Fitzgerald |
100 ul |
EUR 242 |
|
Description: Purified Polyclonal Caspase 1 antibody |
Caspase 1 antibody |
70R-49452 |
Fitzgerald |
100 ul |
EUR 242 |
|
Description: Purified Polyclonal Caspase 1 antibody |
Caspase 1 antibody |
70R-51474 |
Fitzgerald |
100 ul |
EUR 242 |
|
Description: Purified Polyclonal Caspase 1 antibody |
Caspase 1 Antibody |
AF5418 |
Affbiotech |
200ul |
EUR 420 |
Caspase-1 Antibody |
24290-100ul |
SAB |
100ul |
EUR 468 |
Caspase-1 Antibody |
24291-100ul |
SAB |
100ul |
EUR 468 |
Caspase-1 Antibody |
3019-100 |
Biovision |
each |
EUR 483.6 |
Caspase-1 Antibody |
3019-30T |
Biovision |
each |
EUR 175.2 |
Caspase-1 Antibody |
48847-100ul |
SAB |
100ul |
EUR 399.6 |
Caspase-1 Antibody |
48847-50ul |
SAB |
50ul |
EUR 286.8 |
Caspase-1 Antibody |
3459-002mg |
ProSci |
0.02 mg |
EUR 206.18 |
|
Description: Caspase-1 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1β and IL-18. Caspase-1 was initially identified as an IL-1β-converting enzyme; later experiments revealed it to be a mammalian homolog of the C. elegans cell death gene ced-3 whose overexpression can induce apoptosis in fibroblasts. |
Caspase-1 Antibody |
3459-01mg |
ProSci |
0.1 mg |
EUR 523.7 |
|
Description: Caspase-1 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1β and IL-18. Caspase-1 was initially identified as an IL-1β-converting enzyme; later experiments revealed it to be a mammalian homolog of the C. elegans cell death gene ced-3 whose overexpression can induce apoptosis in fibroblasts. |
Caspase-1 Antibody |
3463-002mg |
ProSci |
0.02 mg |
EUR 206.18 |
|
Description: Caspase-1 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1β and IL-18. Caspase-1 was initially identified as an IL-1β-converting enzyme; later experiments revealed it to be a mammalian homolog of the C. elegans cell death gene ced-3 whose overexpression can induce apoptosis in fibroblasts. |
Caspase-1 Antibody |
3463-01mg |
ProSci |
0.1 mg |
EUR 523.7 |
|
Description: Caspase-1 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1β and IL-18. Caspase-1 was initially identified as an IL-1β-converting enzyme; later experiments revealed it to be a mammalian homolog of the C. elegans cell death gene ced-3 whose overexpression can induce apoptosis in fibroblasts. |
Caspase 1 antibody (HRP) |
60R-1915 |
Fitzgerald |
100 ug |
EUR 302 |
|
Description: Rabbit polyclonal Caspase 1 antibody (HRP) |
Caspase 12 (Caspase 12) Antibody |
20-abx007974 |
Abbexa |
-
Ask for price
-
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-
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|
|
|
Caspase 12 (Caspase 12) Antibody |
abx231286-100ug |
Abbexa |
100 ug |
EUR 577.2 |
|
Caspase 12 (Caspase 12) Antibody |
abx432451-200ul |
Abbexa |
200 ul |
EUR 460.8 |
|
Caspase 1 antibody (FITC) |
60R-1916 |
Fitzgerald |
100 ug |
EUR 302 |
|
Description: Rabbit polyclonal Caspase 1 antibody (FITC) |
Caspase-1 Antibody (p20) |
R30510 |
NSJ Bioreagents |
100 ug |
EUR 356.15 |
|
Description: Caspase-1 is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta, interleukin 18, and interleukin 33 precursor proteins. The Caspase-1 gene consists of 10 exons spanning at least 10.6 kb and is mapped to 11q23, a site frequently involved in rearrangement in human cancers, including a number of leukemias and lymphomas. |
Caspase-1 Antibody (p20) |
R30511 |
NSJ Bioreagents |
100 ug |
EUR 356.15 |
|
Description: Caspase-1 is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta, IL-18, and IL-33 precursor proteins. It belongs to a family of cysteine proteases known as caspases that always cleave proteins following an aspartic acid residue. The Caspase-1 gene consists of 10 exons spanning at least 10.6 kb and is mapped to 11q23, a site frequently involved in rearrangement in human cancers, including a number of leukemias and lymphomas, by Southern DNA blot analysis of rodent-human hybrids and by in situ hybridization to normal human metaphase chromosomes. Caspase 1 has been shown to induce cell necrosis or pyroptosis and may function in various developmental stages. |
Caspase-1 Antibody (p10) |
R30597 |
NSJ Bioreagents |
100 ug |
EUR 356.15 |
|
Description: Caspase-1, an apoptosis-related cysteine protease, is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta, IL-18, and IL-33 precursor proteins. It was purified from the cytosol of the THP monocytic cell line and found that the active protease was made up of two peptides, which they called p20 and p10 based on their apparent molecular masses by SDS-PAGE. It belongs to a family of cysteine proteases known as caspases that always cleave proteins following an aspartic acid residue. The CASP1 gene is mapped to 11q23, a site frequently involved in rearrangement in human cancers, including a number of leukemias and lymphomas, by Southern DNA blot analysis of rodent-human hybrids and by in situ hybridization to normal metaphase chromosomes. Caspase-1 has been shown to induce cell necrosis or pyroptosis and may function in various developmental stages. |
Caspase 1 antibody (biotin) |
60R-1917 |
Fitzgerald |
100 ug |
EUR 302 |
|
Description: Rabbit polyclonal Caspase 1 antibody (biotin) |
Caspase 1 antibody (Ser376) |
70R-35444 |
Fitzgerald |
100 ug |
EUR 294 |
|
Description: Purified Rabbit polyclonal Caspase 1 antibody (Ser376) |
Polyclonal Anti- Caspase 4 Antibody |
GWB-BBP367 |
GenWay Biotech |
0.1 mg |
Ask for price |
Anti-Active Caspase-3 antibody |
STJ97448 |
St John's Laboratory |
200 µl |
EUR 236.4 |
Description: Active caspase-3 is a protein encoded by the CASP3 gene which is approximately 31,6 kDa. Active caspase-3 is localised to the cytoplasm. It is involved in the TNFR1 pathway, apoptosis modulation and signalling and respiratory electron transport. This protein falls under the cysteine-aspartic acid protease family. It is a sequential activator of caspases and plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Active caspase-3 is highly expressed in lung, spleen, heart, liver and kidney. Mutations in the CASP3 gene may result in bladder urothelial carcinoma and primary effusion lymphoma. STJ97448 was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. This antibody detects endogenous active caspase-3 protein. |
Polyclonal Caspase-1 Antibody |
APG02382G |
Leading Biology |
0.1 mg |
EUR 790.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-1 . This antibody is tested and proven to work in the following applications: |
Caspase Antibody |
24290 |
SAB |
100ul |
EUR 479 |
Caspase Antibody |
24291 |
SAB |
100ul |
EUR 479 |
Caspase Antibody |
48847 |
SAB |
100ul |
EUR 499 |
Caspase 1 (CASP1) Antibody |
20-abx109605 |
Abbexa |
-
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-
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-
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-
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-
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|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
Caspase 1 (CASP1) Antibody |
20-abx100442 |
Abbexa |
-
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-
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-
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-
Ask for price
-
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|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
Caspase 1 (CASP1) Antibody |
20-abx100443 |
Abbexa |
-
Ask for price
-
Ask for price
-
Ask for price
-
Ask for price
-
Ask for price
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
Caspase 1 (CASP1) Antibody |
20-abx100444 |
Abbexa |
-
Ask for price
-
Ask for price
-
Ask for price
-
Ask for price
-
Ask for price
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
Caspase 1 (CASP1) Antibody |
20-abx100445 |
Abbexa |
-
Ask for price
-
Ask for price
-
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-
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-
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|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
Caspase 1 (CASP1) Antibody |
20-abx100446 |
Abbexa |
-
Ask for price
-
Ask for price
-
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-
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-
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|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
Caspase 1 (CASP1) Antibody |
abx148921-100ug |
Abbexa |
100 ug |
EUR 526.8 |
|
Caspase 1 (CASP1) Antibody |
20-abx007565 |
Abbexa |
-
Ask for price
-
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-
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|
|
|
Caspase 1 (CASP1) Antibody |
abx037580-100ug |
Abbexa |
100 ug |
EUR 469.2 |
|
Caspase 1 (CASP1) Antibody |
abx038263-100ug |
Abbexa |
100 ug |
EUR 469.2 |
|
Caspase 1 (CASP1) Antibody |
20-abx009516 |
Abbexa |
-
Ask for price
-
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-
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|
|
|
Caspase 1 (CASP1) Antibody |
20-abx009517 |
Abbexa |
-
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-
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-
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|
|
|
Caspase 1 (CASP1) Antibody |
20-abx000918 |
Abbexa |
-
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-
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-
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-
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|
- 100 ul
- 200 ul
- 20 ul
- 50 ul
|
|
Caspase 1 (CASP1) Antibody |
abx231284-100ug |
Abbexa |
100 ug |
EUR 610.8 |
|
Caspase 1 (CASP1) Antibody |
20-abx171602 |
Abbexa |
-
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-
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|
|
|
Caspase 1 (CASP1) Antibody |
20-abx171603 |
Abbexa |
-
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-
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|
|
|
Caspase 1 (CASP1) Antibody |
20-abx175717 |
Abbexa |
-
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-
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|
|
|
Caspase 1 (CASP1) Antibody |
20-abx328453 |
Abbexa |
-
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-
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|
|
|
Caspase 1 (CASP1) Antibody |
20-abx324419 |
Abbexa |
-
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-
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|
|
|
Caspase 1 (CASP1) Antibody |
20-abx325046 |
Abbexa |
-
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-
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|
|
|
Caspase 1 (CASP1) Antibody |
20-abx301352 |
Abbexa |
-
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-
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-
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-
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-
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|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
Caspase 1 (CASP1) Antibody |
20-abx322935 |
Abbexa |
-
Ask for price
-
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|
|
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Caspase 1 (CASP1) Antibody |
20-abx323629 |
Abbexa |
-
Ask for price
-
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|
|
|
Caspase 1 (CASP1) Antibody |
20-abx339093 |
Abbexa |
-
Ask for price
-
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|
|
|
Caspase 1 (CASP1) Antibody |
abx000918-100l |
Abbexa |
100 µl |
EUR 400 |
Caspase 1 (CASP1) Antibody |
abx000918-20l |
Abbexa |
20 µl |
EUR 175 |
Caspase 1 (CASP1) Antibody |
abx000918-50l |
Abbexa |
50 µl |
EUR 275 |
Caspase 1 (CASP1) Antibody |
abx100442-100l |
Abbexa |
100 µl |
EUR 262.5 |
Caspase 1 (CASP1) Antibody |
abx100442-1ml |
Abbexa |
1 ml |
EUR 712.5 |
Caspase 1 (CASP1) Antibody |
abx100442-200l |
Abbexa |
200 µl |
EUR 325 |
Caspase 1 (CASP1) Antibody |
abx100443-100l |
Abbexa |
100 µl |
EUR 262.5 |
Caspase 1 (CASP1) Antibody |
abx100443-1ml |
Abbexa |
1 ml |
EUR 712.5 |
Caspase 1 (CASP1) Antibody |
abx100443-200l |
Abbexa |
200 µl |
EUR 325 |
Caspase 1 (CASP1) Antibody |
abx100444-100l |
Abbexa |
100 µl |
EUR 262.5 |
Caspase 1 (CASP1) Antibody |
abx100444-1ml |
Abbexa |
1 ml |
EUR 725 |
Caspase 1 (CASP1) Antibody |
abx100444-200l |
Abbexa |
200 µl |
EUR 337.5 |
Caspase 1 (CASP1) Antibody |
abx100445-100l |
Abbexa |
100 µl |
EUR 275 |
Caspase 1 (CASP1) Antibody |
abx100445-1ml |
Abbexa |
1 ml |
EUR 775 |
Caspase 1 (CASP1) Antibody |
abx100445-200l |
Abbexa |
200 µl |
EUR 350 |
Caspase 1 (CASP1) Antibody |
abx100446-100l |
Abbexa |
100 µl |
EUR 287.5 |
Caspase 1 (CASP1) Antibody |
abx100446-1ml |
Abbexa |
1 ml |
EUR 850 |
Caspase 1 (CASP1) Antibody |
abx100446-200l |
Abbexa |
200 µl |
EUR 375 |
Caspase 1 (CASP1) Antibody |
abx109605-100l |
Abbexa |
100 µl |
EUR 162.5 |
Caspase 1 (CASP1) Antibody |
abx171602-1ml |
Abbexa |
1 ml |
EUR 750 |
Caspase 1 (CASP1) Antibody |
abx171603-1ml |
Abbexa |
1 ml |
EUR 812.5 |
Caspase 1 (CASP1) Antibody |
abx037580-96tests |
Abbexa |
96 tests |
EUR 337.5 |
Caspase 1 (CASP1) Antibody |
abx038263-500g |
Abbexa |
500 µg |
EUR 337.5 |
Caspase 1 (CASP1) Antibody |
abx301352-100g |
Abbexa |
100 µg |
EUR 362.5 |
Caspase 1 (CASP1) Antibody |
abx301352-20g |
Abbexa |
20 µg |
EUR 162.5 |
Caspase 1 (CASP1) Antibody |
abx301352-50g |
Abbexa |
50 µg |
EUR 250 |
Caspase 1 (CASP1) Antibody |
abx148921-1096tests |
Abbexa |
10 × 96 tests |
Ask for price |
Caspase 1 (CASP1) Antibody |
abx148921-596tests |
Abbexa |
5 × 96 tests |
Ask for price |
Caspase 1 (CASP1) Antibody |
abx148921-96tests |
Abbexa |
96 tests |
EUR 350 |
Caspase 1 (CASP1) Antibody |
abx231284-100g |
Abbexa |
100 µg |
EUR 350 |
Caspase 1 (CASP1) Antibody |
abx325046-100g |
Abbexa |
100 µg |
EUR 250 |
Caspase 1 (CASP1) Antibody |
abx325046-50g |
Abbexa |
50 µg |
EUR 187.5 |
Caspase 1 (CASP1) Antibody |
abx339093-100l |
Abbexa |
100 µl |
EUR 350 |
Caspase 1 (CASP1) Antibody |
abx339093-50l |
Abbexa |
50 µl |
EUR 250 |
Caspase 1 (CASP1) Antibody |
abx328453-100g |
Abbexa |
100 µg |
EUR 250 |
Caspase 1 (CASP1) Antibody |
abx328453-50g |
Abbexa |
50 µg |
EUR 187.5 |
Caspase 1 p20 Antibody |
20-abx009515 |
Abbexa |
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Ask for price
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Caspase 1 p10 Antibody |
20-abx009518 |
Abbexa |
-
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Caspase 1 p10 Antibody |
E38PA1131 |
EnoGene |
100ul |
EUR 225 |
Description: Available in various conjugation types. |
Caspase 1 p20 antibody |
70R-49453 |
Fitzgerald |
100 ul |
EUR 242 |
|
Description: Purified Polyclonal Caspase 1 p20 antibody |
CASPASE-1 Antibody (C-term) |
GWB-8ED0B9 |
GenWay Biotech |
0.1 mg |
Ask for price |
CASPASE-1 Antibody (C-term) |
GWB-E49E0E |
GenWay Biotech |
0.05 mg |
Ask for price |
Mouse anti-active Caspase 3 Antibody |
DL95470A-100ul |
DL Develop |
100 ul |
EUR 325 |
|
Description: CPP32; Caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1 |
Mouse anti-active Caspase 3 Antibody |
DL95470A-50ul |
DL Develop |
50 ul |
EUR 227.5 |
|
Description: CPP32; Caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1 |
Mouse anti-active Caspase 3 Antibody |
YLD8376-100ul |
Shanghai YL Biotech |
100 ul |
EUR 320 |
|
Description: Mouse monoclonal antibody to active Caspase 3 |
Mouse anti-active Caspase 3 Antibody |
YLD8376-50ul |
Shanghai YL Biotech |
50 ul |
EUR 200 |
|
Description: Mouse monoclonal antibody to active Caspase 3 |
Anti-Active+Pro Caspase-9 Antibody |
R1308-12 |
HUABIO |
100ul |
EUR 189 |
|
Description: Caspase-9 (ICE-LAP6, Mch6) is an important member of the cysteine aspartic acid protease (caspase) family. It is known to be involved in the activation cascade of caspases responsible for apoptosis execution. Upon apoptotic stimulation, cytochrome c released from mitochondria associates with the 47 kDa procaspase-9/Apaf 1. Apaf-1 mediated activation of caspase-9 involves instrinsic proteolytic processing resulting in cleavage at Asp315 and producing a p35 subunit. Another cleavage occurs at Asp330 producing a p37 subunit that can serve to amplify the apoptotic response. Cleaved caspase-9 further processes other caspase members, including caspase-3 and caspase-7, to initiate a caspase cascade, which leads to apoptosis. |
Polyclonal CASP1 / Caspase 1 Antibody |
APG02372G |
Leading Biology |
0.05mg |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human CASP1 / Caspase 1 . This antibody is tested and proven to work in the following applications: |
Caspase-1 Polyclonal Antibody |
ABP50851-003ml |
Abbkine |
0.03ml |
EUR 189.6 |
|
Description: A polyclonal antibody for detection of Caspase-1 from Human, Mouse, Rat. This Caspase-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Caspase-1 around the non-phosphorylation site of S376 |
Caspase-1 Polyclonal Antibody |
ABP50851-01ml |
Abbkine |
0.1ml |
EUR 346.8 |
|
Description: A polyclonal antibody for detection of Caspase-1 from Human, Mouse, Rat. This Caspase-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Caspase-1 around the non-phosphorylation site of S376 |
Caspase-1 Polyclonal Antibody |
ABP50851-02ml |
Abbkine |
0.2ml |
EUR 496.8 |
|
Description: A polyclonal antibody for detection of Caspase-1 from Human, Mouse, Rat. This Caspase-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Caspase-1 around the non-phosphorylation site of S376 |
Caspase-1 Polyclonal Antibody |
ABP50851-100uL |
Abbkine |
100 μL |
EUR 239 |
Description: Rabbit Anti-Caspase-1 Polyclonal Antibody |
Caspase-1 Polyclonal Antibody |
ABP50851-200uL |
Abbkine |
200 μL |
EUR 379 |
Description: Rabbit Anti-Caspase-1 Polyclonal Antibody |
Caspase-1 Polyclonal Antibody |
ABP50851-30uL |
Abbkine |
30 μL |
EUR 109 |
Description: Rabbit Anti-Caspase-1 Polyclonal Antibody |
Caspase-1 Polyclonal Antibody |
ABP57468-003ml |
Abbkine |
0.03ml |
EUR 189.6 |
|
Description: A polyclonal antibody for detection of Caspase-1 from Human, Rat. This Caspase-1 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from Caspase-1 at AA range: internal |
Caspase-1 Polyclonal Antibody |
ABP57468-01ml |
Abbkine |
0.1ml |
EUR 346.8 |
|
Description: A polyclonal antibody for detection of Caspase-1 from Human, Rat. This Caspase-1 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from Caspase-1 at AA range: internal |
Caspase-1 Polyclonal Antibody |
ABP57468-02ml |
Abbkine |
0.2ml |
EUR 496.8 |
|
Description: A polyclonal antibody for detection of Caspase-1 from Human, Rat. This Caspase-1 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from Caspase-1 at AA range: internal |
Caspase-1 Polyclonal Antibody |
ABP56678-003ml |
Abbkine |
0.03ml |
EUR 189.6 |
|
Description: A polyclonal antibody for detection of Caspase-1 from Human, Monkey. This Caspase-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Caspase-1 at AA range: 270-350 |
Caspase-1 Polyclonal Antibody |
ABP56678-01ml |
Abbkine |
0.1ml |
EUR 346.8 |
|
Description: A polyclonal antibody for detection of Caspase-1 from Human, Monkey. This Caspase-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Caspase-1 at AA range: 270-350 |
Caspase-1 Polyclonal Antibody |
ABP56678-02ml |
Abbkine |
0.2ml |
EUR 496.8 |
|
Description: A polyclonal antibody for detection of Caspase-1 from Human, Monkey. This Caspase-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Caspase-1 at AA range: 270-350 |
Caspase-1 Polyclonal Antibody |
E20-10021 |
EnoGene |
100ug |
EUR 225 |
Description: Available in various conjugation types. |
Caspase-1 Polyclonal Antibody |
E20-70652 |
EnoGene |
100ug |
EUR 225 |
Description: Available in various conjugation types. |
Caspase-1 Conjugated Antibody |
C48847 |
SAB |
100ul |
EUR 476.4 |
Caspase-1 Polyclonal Antibody |
E44H07185 |
EnoGene |
100ul |
EUR 255 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
Caspase-1 Polyclonal Antibody |
E44H01721 |
EnoGene |
100ul |
EUR 255 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
Caspase-1 Polyclonal Antibody |
E44H00021 |
EnoGene |
100ul |
EUR 255 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
Mild microscopic examination evidenced that the severity of histopathological lesions induced by CPF have been alleviated in rats co-exposed to CPF and Mn. In conclusion, the outcomes spotlight that co-exposure to CPF and Mn in rats assuaged CPF-induced oxidative stress, irritation and <em>caspase</em>-Three activation within the liver and kidney of the rats.