Background Transforming biomarkers carry excessive potential for predicting hostile occasions in persistent coronary heart failure ( CHF ) sufferers. Nonetheless, temporal patterns throughout the course of CHF , and particularly the trajectory earlier than an hostile occasion, are unknown. We studied the prognostic worth of temporal patterns of cardiac reworking biomarker candidates in steady sufferers with CHF from the Bio-SHiFT (Serial Biomarker Measurements and New Echocardiographic Methods in Persistent Coronary heart Failure Sufferers End in Tailor-made Prediction of Prognosis) research. Strategies and Outcomes In 263 CHF sufferers, we carried out trimonthly blood sampling throughout a median follow-up of two.2 years.
For the evaluation, we chosen all baseline samples, the two samples closest to the first finish level ( PE ), or the final pattern out there for finish point-free sufferers. Thus, in 567 samples, we measured suppression of tumorigenicity-2, galectin-3, galectin-4, progress differentiation factor-15, matrix metalloproteinase-2, 3, and 9, tissue inhibitor metalloproteinase-4, perlecan, aminopeptidase-N, <em>caspase</em>-3, cathepsin-D, cathepsin-Z, and cystatin-B. The PE was a composite of cardiovascular mortality, coronary heart transplantation, left ventricular help machine implantation, and HF hospitalization. Associations between repeatedly measured biomarker candidates and the PE had been investigated by joint modeling. Median age was 68 (interquartile vary: 59-76) years with 72% males; 70 sufferers reached the PE . Repeatedly measured suppression of tumorigenicity-2, galectin-3, galectin-4, progress differentiation factor-15, matrix metalloproteinase-2 and 9, tissue inhibitor metalloproteinase-4, perlecan, cathepsin-D, and cystatin-B ranges had been considerably related to the PE , and elevated because the PE approached. The slopes of biomarker trajectories had been additionally predictors of scientific end result, impartial of their absolute stage. Associations continued after adjustment for scientific traits and pharmacological therapy.
Suppression of tumorigenicity-2 was the strongest predictor (hazard ratio: 7.55 per SD distinction, 95% CI : 5.53-10.30), adopted by progress differentiation factor-15 and matrix metalloproteinase-2. Conclusions Temporal patterns of reworking biomarker candidates predict hostile scientific outcomes in CHF. JNK and its downstream transcriptional elements together with c-Jun, activating transcription issue 2 (ATF2), and JunD had been all considerably phosphorylated in CIH rats. Nonetheless, pretreatment of NF-κB inhibitor BAY 11-7082 inhibited the activation of NF-κB below CIH situation and likewise considerably decreased the phosphorylation of JNK in addition to c-Jun, ATF2, and JunD.
Novel compound VB-037 inhibits Aβ aggregation and promotes neurite outgrowth via enhancement of HSP27 and discount of P38 and JNK-mediated irritation in cell fashions for Alzheimer’s illness.
The pathogenesis of Alzheimer’s illness (AD) is concerned within the aggregation of misfolded amyloid β (Aβ), which upregulates the exercise of acetylcholinesterase (AChE), will increase the manufacturing of reactive oxygen species (ROS), enhances neuroinflammation, and finally results in neuronal dying. Due to this fact, compounds concentrating on these mechanisms could also be candidates for multitarget medication in AD therapy. We discovered that two quinoline derivatives, VB-030 and VB-037, markedly decreased Aβ aggregation and ROS ranges within the thioflavin T biochemical assay and Tet-On Aβ-green fluorescent protein (GFP) 293 AD cell mannequin. These compounds additional improved neurite outgrowth, decreased AChE exercise and upregulated the molecular chaperone warmth shock protein household B [small] member 1 (HSP27), whereas knockdown of HSP27 counteracted the compounds’ neuroprotective results on the Tet-On neuronal mannequin. Moreover, VB-037 attenuated lipopolysaccharide (LPS)/interferon (IFN)-γ-induced activation of BV-2 microglial cells.
As well as, VB-037 demonstrated its potential to decrease LPS/IFN-γ-induced upregulation of <em>caspase</em> 1 exercise, expression of interleukin (IL)-1β, and lively phosphorylation of mitogen-activated protein kinase <em>14</em> (P38), mitogen-activated protein kinase 8 (JNK), and Jun proto-oncogene, AP-1 transcription issue subunit (JUN) signalings, in addition to enhance cell viability within the Tet-On neuronal mannequin. Our findings strongly point out the potential of VB-037 for modifying AD development by concentrating on a number of mechanisms, thereby providing a brand new drug improvement avenue for AD therapy. Hepatitis B virus X (HBx), a viral onco-protein encoded by HBV, can promote oncogenesis of HCC. Nonetheless, the mechanism of HBx in hepatocarcinogenesis remains to be unclear. On this research, we set up a brand new mouse mannequin with regular immune system to analyze the position of HBx and its purposeful mechanisms below regular immune operate.
The animal mannequin was established by injecting HBx-EGFP-<em>14</em>-19 cells into the hepatic portal vein of KM mice. To confirm the mouse mannequin, the expression of HBx within the liver tissue of mice was detected by qRT-PCR, western blotting and immunohistochemistry. The apoptosis index was calculated utilizing the terminal deoxynucleotidyl transferase-dUTP nick-end labeling (TUNEL) assay, and the expression ranges of apoptosis-related and cell cycle-related elements had been measured.
Metformin alleviates hyperglycemia-induced endothelial impairment by downregulating autophagy by way of the Hedgehog pathway.
Research relating to macroautophagic/autophagic regulation in endothelial cells (ECs) below diabetic circumstances are very restricted. Medical proof establishes an endothelial protecting impact of metformin, however the underlying mechanisms stay unclear. We aimed to analyze whether or not metformin exerts its protecting position in opposition to hyperglycemia-induced endothelial impairment via the autophagy equipment. db/db mice had been handled with intravitreal metformin injections. Human umbilical vein endothelial cells (HUVECs) had been cultured both in regular glucose (NG, 5.5 mM) or excessive glucose (HG, 33 mM) medium within the presence or absence of metformin for 72 h. We noticed an apparent inhibition of hyperglycemia-triggered autophagosome synthesis in each the diabetic retinal vasculature and cultured HUVECs by metformin, together with restoration of hyperglycemia-impaired Hedgehog (Hh) pathway exercise.
Particularly, deletion of ATG7 in retinal vascular ECs of db/db mice and cultured HUVECs indicated a detrimental position of autophagy in hyperglycemia-induced endothelial dysfunction. Pretreatment with GANT61, a Hh pathway inhibitor, abolished the metformin-mediated downregulation of autophagy and endothelial protecting motion. Moreover, GLI-family (transcription elements of the Hh pathway) knockdown in HUVECs and retinal vasculature revealed that downregulation of hyperglycemia-activated autophagy by the metformin-mediated Hh pathway activation was GLI1 dependent. Mechanistically, GLI1 knockdown-triggered autophagy was associated to upregulation of BNIP3, which subsequently disrupted the affiliation of BECN1/Beclin 1 and BCL2.
Anti-Caspase-12 Antibody |
A04700 |
BosterBio |
100ug |
EUR 471 |
Description: Rabbit Polyclonal Caspase-12 Antibody. Validated in IHC, WB and tested in Human, Mouse, Rat. |
anti- Caspase 12 antibody |
FNab01286 |
FN Test |
100µg |
EUR 505.25 |
|
Description: Antibody raised against Caspase 12 |
Anti-Caspase-12/CASP12 Antibody |
PA2103 |
BosterBio |
100ug/vial |
EUR 334 |
Caspase 12 antibody |
70R-51166 |
Fitzgerald |
100 ul |
EUR 244 |
Description: Purified Polyclonal Caspase 12 antibody |
Caspase 12 antibody |
20R-1513 |
Fitzgerald |
100 ug |
EUR 673 |
Description: Rabbit polyclonal Caspase 12 antibody |
Caspase 12 antibody |
70R-11740 |
Fitzgerald |
100 ug |
EUR 460 |
Description: Rabbit polyclonal Caspase 12 antibody |
Caspase-12 Antibody |
3282-100 |
Biovision |
|
EUR 354 |
Caspase-12 Antibody |
3282-30T |
Biovision |
|
EUR 146 |
Caspase-12 Antibody |
24119-100ul |
SAB |
100ul |
EUR 390 |
Caspase-12 Antibody |
24120-100ul |
SAB |
100ul |
EUR 390 |
Human cysteinyl aspartate specific proteinases 12,Caspase-12 ELISA Kit |
201-12-0763 |
SunredBio |
96 tests |
EUR 440 |
|
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
Rabbit Polyclonal antibody Anti-CRBN |
Anti-CRBN |
ImmunoStep |
50 µg |
EUR 349 |
Caspase 12 Polyclonal Antibody |
ABP50853-003ml |
Abbkine |
0.03ml |
EUR 158 |
|
Description: A polyclonal antibody for detection of Caspase 12 from Human. This Caspase 12 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Caspase12 |
Caspase 12 Polyclonal Antibody |
ABP50853-01ml |
Abbkine |
0.1ml |
EUR 289 |
|
Description: A polyclonal antibody for detection of Caspase 12 from Human. This Caspase 12 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Caspase12 |
Caspase 12 Polyclonal Antibody |
ABP50853-02ml |
Abbkine |
0.2ml |
EUR 414 |
|
Description: A polyclonal antibody for detection of Caspase 12 from Human. This Caspase 12 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Caspase12 |
Caspase 12 (CASP12) Antibody |
20-abx129818 |
Abbexa |
-
EUR 411.00
-
EUR 133.00
-
EUR 1135.00
-
EUR 551.00
-
EUR 314.00
|
-
100 ug
-
10 ug
-
1 mg
-
200 ug
-
50 ug
|
|
Caspase 12 (CASP12) Antibody |
20-abx111421 |
Abbexa |
|
|
|
Caspase 12 (CASP12) Antibody |
20-abx318255 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
-
100 ug
-
1 mg
-
200 ug
-
20 ug
-
50 ug
|
|
Caspase 12 (Casp12) Antibody |
20-abx318989 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
-
100 ug
-
1 mg
-
200 ug
-
20 ug
-
50 ug
|
|
Caspase 12 (CASP12) Antibody |
20-abx213378 |
Abbexa |
|
|
|
Caspase 12 (CASP12) Antibody |
20-abx210324 |
Abbexa |
|
|
|
Caspase 12 (CASP12) Antibody |
abx216233-100ug |
Abbexa |
100 ug |
EUR 439 |
|
Caspase 12 (CASP12) Antibody |
20-abx324638 |
Abbexa |
|
|
|
Caspase 12 (CASP12) Antibody |
20-abx100899 |
Abbexa |
-
EUR 425.00
-
EUR 133.00
-
EUR 1177.00
-
EUR 578.00
-
EUR 328.00
|
-
100 ug
-
10 ug
-
1 mg
-
200 ug
-
50 ug
|
|
Caspase 12 (CASP12) Antibody |
abx026563-400ul |
Abbexa |
400 ul |
EUR 523 |
|
Caspase 12 (CASP12) Antibody |
abx026563-80l |
Abbexa |
80 µl |
EUR 286 |
|
Polyclonal Caspase-12 Antibody |
APR00058G |
Leading Biology |
0.1mg |
EUR 484 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 . This antibody is tested and proven to work in the following applications: |
Polyclonal Caspase-12 Antibody |
APR06275G |
Leading Biology |
0.1 mg |
EUR 659 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 . This antibody is tested and proven to work in the following applications: |
Polyclonal Caspase-12 Antibody |
APR06276G |
Leading Biology |
0.1 mg |
EUR 659 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 . This antibody is tested and proven to work in the following applications: |
Caspase-12 Antibody (Large) |
24208-100ul |
SAB |
100ul |
EUR 390 |
Caspase-12 Antibody (Small) |
24209-100ul |
SAB |
100ul |
EUR 390 |
Caspase 12 (Casp12) Antibody (HRP) |
20-abx318990 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
-
100 ug
-
1 mg
-
200 ug
-
20 ug
-
50 ug
|
|
Caspase 12 (Casp12) Antibody (FITC) |
20-abx318991 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
-
100 ug
-
1 mg
-
200 ug
-
20 ug
-
50 ug
|
|
Caspase 12 (Casp12) Antibody (Biotin) |
20-abx318992 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
-
100 ug
-
1 mg
-
200 ug
-
20 ug
-
50 ug
|
|
Caspase 12 (CASP12) Antibody (HRP) |
20-abx316303 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
-
100 ug
-
1 mg
-
200 ug
-
20 ug
-
50 ug
|
|
Caspase 12 (CASP12) Antibody (FITC) |
20-abx316304 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
-
100 ug
-
1 mg
-
200 ug
-
20 ug
-
50 ug
|
|
Caspase 12 (CASP12) Antibody (Biotin) |
20-abx316305 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
-
100 ug
-
1 mg
-
200 ug
-
20 ug
-
50 ug
|
|
Polyclonal Caspase-12 Antibody (Large) |
APR06327G |
Leading Biology |
0.1 mg |
EUR 659 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 (Large). This antibody is tested and proven to work in the following applications: |
Polyclonal Caspase-12 Antibody (Small) |
APR06328G |
Leading Biology |
0.1 mg |
EUR 659 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 (Small). This antibody is tested and proven to work in the following applications: |
Rabbit Anti Caspase-12 (Aa100-116) Polyclonal Antibody |
CPBT-66303RC |
Creative Diagnostics |
0.1 mg |
EUR 580 |
99445-12 DCT 12 X 75MM |
99445-12 |
CORNING |
250/pk |
EUR 67 |
Description: Disposable Culture Tubes; DCT's, CGW |
Caspase 12 Blocking Peptide |
33R-10465 |
Fitzgerald |
50 ug |
EUR 349 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Caspase 12 antibody, catalog no. 20R-1513 |
Caspase 12 Blocking Peptide |
33R-10701 |
Fitzgerald |
50 ug |
EUR 191 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Caspase 12 antibody, catalog no. 70R-11740 |
Caspase-12 Blocking Peptide |
3282BP-50 |
Biovision |
|
EUR 153 |
Caspase 12 Assay Kit |
55R-1290 |
Fitzgerald |
25 assays |
EUR 328 |
Description: Assay Kit for detection of Capase 12 activity in the research laboratory |
Recombinant Caspase 12 (CASP12) |
4-RPA682Mu01 |
Cloud-Clone |
-
EUR 467.36
-
EUR 228.00
-
EUR 1477.60
-
EUR 559.20
-
EUR 1018.40
-
EUR 376.00
-
EUR 3544.00
|
-
100 ug
-
10ug
-
1 mg
-
200 ug
-
500 ug
-
50ug
-
5 mg
|
|
Description: Recombinant Mouse Caspase 12 expressed in: E.coli |
Recombinant Caspase 12 (CASP12) |
4-RPA682Ra01 |
Cloud-Clone |
-
EUR 494.24
-
EUR 235.00
-
EUR 1578.40
-
EUR 592.80
-
EUR 1085.60
-
EUR 394.00
-
EUR 3796.00
|
-
100 ug
-
10ug
-
1 mg
-
200 ug
-
500 ug
-
50ug
-
5 mg
|
|
Description: Recombinant Rat Caspase 12 expressed in: E.coli |
Caspase 12 Blocking Peptide |
20-abx064041 |
Abbexa |
|
|
|
Caspase-12 Rabbit pAb |
A0217-100ul |
Abclonal |
100 ul |
EUR 308 |
Caspase-12 Rabbit pAb |
A0217-200ul |
Abclonal |
200 ul |
EUR 459 |
Caspase-12 Rabbit pAb |
A0217-20ul |
Abclonal |
20 ul |
EUR 183 |
Caspase-12 Rabbit pAb |
A0217-50ul |
Abclonal |
50 ul |
EUR 223 |
Human Caspase 12,Casp-12 ELISA Kit |
CN-03708H1 |
ChemNorm |
96T |
EUR 486 |
Human Caspase 12,Casp-12 ELISA Kit |
CN-03708H2 |
ChemNorm |
48T |
EUR 336 |
Caspase 12 (CASP12) Polyclonal Antibody (Mouse) |
4-PAA682Mu01 |
Cloud-Clone |
-
EUR 236.00
-
EUR 2338.00
-
EUR 586.00
-
EUR 294.00
-
EUR 209.00
|
-
100ul
-
10ml
-
1ml
-
200ul
-
20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12) |
Human Caspase 12 ELISA kit |
E01C0690-192T |
BlueGene |
192 tests |
EUR 1270 |
|
Description: A competitive ELISA for quantitative measurement of Human Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Caspase 12 ELISA kit |
E01C0690-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
|
Description: A competitive ELISA for quantitative measurement of Human Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Caspase 12 ELISA kit |
E01C0690-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Human Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Caspase 12 ELISA kit |
E03C0690-192T |
BlueGene |
192 tests |
EUR 1270 |
|
Description: A competitive ELISA for quantitative measurement of Mouse Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Caspase 12 ELISA kit |
E03C0690-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
|
Description: A competitive ELISA for quantitative measurement of Mouse Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Caspase 12 ELISA kit |
E03C0690-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Mouse Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit Caspase 12 ELISA kit |
E04C0690-192T |
BlueGene |
192 tests |
EUR 1270 |
|
Description: A competitive ELISA for quantitative measurement of Rabbit Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit Caspase 12 ELISA kit |
E04C0690-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
|
Description: A competitive ELISA for quantitative measurement of Rabbit Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit Caspase 12 ELISA kit |
E04C0690-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Rabbit Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Caspase 12 ELISA kit |
E02C0690-192T |
BlueGene |
192 tests |
EUR 1270 |
|
Description: A competitive ELISA for quantitative measurement of Rat Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Caspase 12 ELISA kit |
E02C0690-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
|
Description: A competitive ELISA for quantitative measurement of Rat Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Caspase 12 ELISA kit |
E02C0690-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Rat Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Caspase-12 Substrate ATAD-AFC |
1117-1000 |
Biovision |
|
EUR 1088 |
Caspase-12 Substrate ATAD-AFC |
1117-200 |
Biovision |
|
EUR 436 |
Monkey Caspase 12 ELISA kit |
E09C0690-192T |
BlueGene |
192 tests |
EUR 1270 |
|
Description: A competitive ELISA for quantitative measurement of Monkey Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Caspase 12 ELISA kit |
E09C0690-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
|
Description: A competitive ELISA for quantitative measurement of Monkey Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Caspase 12 ELISA kit |
E09C0690-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Monkey Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig Caspase 12 ELISA kit |
E07C0690-192T |
BlueGene |
192 tests |
EUR 1270 |
|
Description: A competitive ELISA for quantitative measurement of Porcine Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig Caspase 12 ELISA kit |
E07C0690-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
|
Description: A competitive ELISA for quantitative measurement of Porcine Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig Caspase 12 ELISA kit |
E07C0690-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Porcine Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog Caspase 12 ELISA kit |
E08C0690-192T |
BlueGene |
192 tests |
EUR 1270 |
|
Description: A competitive ELISA for quantitative measurement of Canine Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog Caspase 12 ELISA kit |
E08C0690-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
|
Description: A competitive ELISA for quantitative measurement of Canine Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog Caspase 12 ELISA kit |
E08C0690-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Canine Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat Caspase 12 ELISA kit |
E06C0690-192T |
BlueGene |
192 tests |
EUR 1270 |
|
Description: A competitive ELISA for quantitative measurement of Goat Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat Caspase 12 ELISA kit |
E06C0690-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
|
Description: A competitive ELISA for quantitative measurement of Goat Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat Caspase 12 ELISA kit |
E06C0690-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Goat Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Caspase-12 Fluorometric Assay Kit |
K139-100 |
Biovision |
|
EUR 501 |
Caspase-12 Fluorometric Assay Kit |
K139-25 |
Biovision |
|
EUR 256 |
Mouse Caspase 12 (CASP12) Protein |
20-abx167225 |
Abbexa |
-
EUR 648.00
-
EUR 272.00
-
EUR 1998.00
-
EUR 773.00
-
EUR 467.00
|
-
100 ug
-
10 ug
-
1 mg
-
200 ug
-
50 ug
|
|
Rat Caspase 12 (CASP12) Protein |
20-abx065753 |
Abbexa |
-
EUR 690.00
-
EUR 286.00
-
EUR 2124.00
-
EUR 815.00
-
EUR 495.00
|
-
100 ug
-
10 ug
-
1 mg
-
200 ug
-
50 ug
|
|
Anserini Caspase-12 ELISA Kit |
EAC0697 |
Abclonal |
96Tests |
EUR 521 |
Rat Caspase-12 ELISA Kit |
ERC0697 |
Abclonal |
96Tests |
EUR 521 |
Rabbit Caspase-12 ELISA Kit |
ERTC0697 |
Abclonal |
96Tests |
EUR 521 |
Mouse Caspase-12 ELISA Kit |
EMC0697 |
Abclonal |
96Tests |
EUR 521 |
Porcine Caspase-12 ELISA Kit |
EPC0697 |
Abclonal |
96Tests |
EUR 521 |
Human Caspase-12 ELISA Kit |
EHC0697 |
Abclonal |
96Tests |
EUR 521 |
Canine Caspase-12 ELISA Kit |
ECC0697 |
Abclonal |
96Tests |
EUR 521 |
Goat Caspase-12 ELISA Kit |
EGTC0697 |
Abclonal |
96Tests |
EUR 521 |
Bovine Caspase-12 ELISA Kit |
EBC0697 |
Abclonal |
96Tests |
EUR 521 |
Caspase-12 Fluorometric Assay Kit |
K2150-100 |
ApexBio |
100 assays |
EUR 529 |
Caspase-12 Fluorometric Assay Kit |
K2150-25 |
ApexBio |
25 assays |
EUR 251 |
Individual Reaction Mix 12 |
G065-12 |
ABM |
200 reactions |
EUR 167 |
Human 12-lipoxygenase,LOX-12 ELISA Kit |
201-12-0949 |
SunredBio |
96 tests |
EUR 440 |
|
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
Caspase 12 (CASP12) Polyclonal Antibody (Mouse), APC |
4-PAA682Mu01-APC |
Cloud-Clone |
-
EUR 329.00
-
EUR 3041.00
-
EUR 854.00
-
EUR 416.00
-
EUR 212.00
|
-
100ul
-
10ml
-
1ml
-
200ul
-
20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with APC. |
Caspase 12 (CASP12) Polyclonal Antibody (Mouse), Biotinylated |
4-PAA682Mu01-Biotin |
Cloud-Clone |
-
EUR 299.00
-
EUR 2288.00
-
EUR 684.00
-
EUR 363.00
-
EUR 214.00
|
-
100ul
-
10ml
-
1ml
-
200ul
-
20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with Biotin. |
Caspase 12 (CASP12) Polyclonal Antibody (Mouse), Cy3 |
4-PAA682Mu01-Cy3 |
Cloud-Clone |
-
EUR 397.00
-
EUR 4013.00
-
EUR 1097.00
-
EUR 513.00
-
EUR 241.00
|
-
100ul
-
10ml
-
1ml
-
200ul
-
20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with Cy3. |
Caspase 12 (CASP12) Polyclonal Antibody (Mouse), FITC |
4-PAA682Mu01-FITC |
Cloud-Clone |
-
EUR 283.00
-
EUR 2452.00
-
EUR 703.00
-
EUR 353.00
-
EUR 189.00
|
-
100ul
-
10ml
-
1ml
-
200ul
-
20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with FITC. |
Caspase 12 (CASP12) Polyclonal Antibody (Mouse), HRP |
4-PAA682Mu01-HRP |
Cloud-Clone |
-
EUR 302.00
-
EUR 2652.00
-
EUR 756.00
-
EUR 377.00
-
EUR 200.00
|
-
100ul
-
10ml
-
1ml
-
200ul
-
20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with HRP. |
Caspase 12 (CASP12) Polyclonal Antibody (Mouse), PE |
4-PAA682Mu01-PE |
Cloud-Clone |
-
EUR 283.00
-
EUR 2452.00
-
EUR 703.00
-
EUR 353.00
-
EUR 189.00
|
-
100ul
-
10ml
-
1ml
-
200ul
-
20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with PE. |
Caspase 12 (CASP12) Polyclonal Antibody (Mouse, Rat) |
4-PAA682Ra01 |
Cloud-Clone |
-
EUR 243.00
-
EUR 2457.00
-
EUR 613.00
-
EUR 305.00
-
EUR 212.00
|
-
100ul
-
10ml
-
1ml
-
200ul
-
20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse, Rat Caspase 12 (CASP12) |
Tissue Culture Plate, 12 Well |
TCP20-12 |
Bio Basic |
1 UNIT |
EUR 53.48 |
|
Human Interleukin 12,IL-12/P70 ELISA KIT |
201-12-0100 |
SunredBio |
96 tests |
EUR 440 |
|
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
Human Interleukin 12,IL-12/P40 ELISA KIT |
201-12-0101 |
SunredBio |
96 tests |
EUR 440 |
|
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
Caspase-12 Inhibitor Z-ATAD-FMK |
1079-100 |
Biovision |
|
EUR 218 |
Caspase-12 Inhibitor Z-ATAD-FMK |
1079-20C |
Biovision |
|
EUR 218 |
CaspGLOW Active Caspase 12 Staining Kit |
55R-1291 |
Fitzgerald |
25 assays |
EUR 282 |
Description: Caspase 12 Staining Kit for use activity in the research laboratory |
Mouse Caspase 12 (CASP12) ELISA Kit |
SEA682Mu-10x96wellstestplate |
Cloud-Clone |
10x96-wells test plate |
EUR 4862.4 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Caspase 12 (CASP12) in tissue homogenates, cell lysates and other biological fluids. |
Mouse Caspase 12 (CASP12) ELISA Kit |
SEA682Mu-1x48wellstestplate |
Cloud-Clone |
1x48-wells test plate |
EUR 488.08 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Caspase 12 (CASP12) in tissue homogenates, cell lysates and other biological fluids. |
Mouse Caspase 12 (CASP12) ELISA Kit |
SEA682Mu-1x96wellstestplate |
Cloud-Clone |
1x96-wells test plate |
EUR 654.4 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Caspase 12 (CASP12) in tissue homogenates, cell lysates and other biological fluids. |
Mouse Caspase 12 (CASP12) ELISA Kit |
SEA682Mu-5x96wellstestplate |
Cloud-Clone |
5x96-wells test plate |
EUR 2644.8 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Caspase 12 (CASP12) in tissue homogenates, cell lysates and other biological fluids. |
Mouse Caspase 12 (CASP12) ELISA Kit |
4-SEA682Mu |
Cloud-Clone |
-
EUR 4913.00
-
EUR 2595.00
-
EUR 655.00
|
-
10 plates of 96 wells
-
5 plates of 96 wells
-
1 plate of 96 wells
|
|
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Caspase 12 (CASP12) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. |
Guinea pig Caspase 12 ELISA kit |
E05C0690-192T |
BlueGene |
192 tests |
EUR 1270 |
|
Description: A competitive ELISA for quantitative measurement of Guinea pig Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Guinea pig Caspase 12 ELISA kit |
E05C0690-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
|
Description: A competitive ELISA for quantitative measurement of Guinea pig Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Guinea pig Caspase 12 ELISA kit |
E05C0690-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Guinea pig Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Caspase 12 (CASP12) CLIA Kit |
20-abx491877 |
Abbexa |
-
EUR 7973.00
-
EUR 4246.00
-
EUR 981.00
|
-
10 × 96 tests
-
5 × 96 tests
-
96 tests
|
|
Rat Caspase 12 (CASP12) ELISA Kit |
abx353550-96tests |
Abbexa |
96 tests |
EUR 786 |
|
Human Caspase 12 (CASP12) ELISA Kit |
abx358592-96tests |
Abbexa |
96 tests |
EUR 707 |
|
Human Caspase 12 (CASP12) ELISA Kit |
abx513694-96tests |
Abbexa |
96 tests |
EUR 707 |
|
Human Caspase 12 (CASP12) CLIA Kit |
abx196504-96tests |
Abbexa |
96 tests |
EUR 825 |
|
Rat Caspase 12 (CASP12) CLIA Kit |
abx196787-96tests |
Abbexa |
96 tests |
EUR 825 |
|
Human Caspase 12 (CASP12) ELISA Kit |
20-abx259273 |
Abbexa |
-
EUR 6642.00
-
EUR 3542.00
-
EUR 825.00
|
-
10 × 96 tests
-
5 × 96 tests
-
96 tests
|
|
Mouse Caspase 12 (CASP12) ELISA Kit |
abx254790-96tests |
Abbexa |
96 tests |
EUR 668 |
|
Rat Caspase 12 (CASP12) ELISA Kit |
abx256323-96tests |
Abbexa |
96 tests |
EUR 786 |
|
Mouse Caspase 12 (CASP12) ELISA Kit |
20-abx258452 |
Abbexa |
-
EUR 7378.00
-
EUR 3933.00
-
EUR 911.00
|
-
10 × 96 tests
-
5 × 96 tests
-
96 tests
|
|
Mouse Caspase 12 ELISA Kit (CASP12) |
RK02662 |
Abclonal |
96 Tests |
EUR 521 |
Mouse Caspase 12(CASP13)ELISA kit |
GA-E0794MS-48T |
GenAsia Biotech |
48T |
EUR 336 |
Mouse Caspase 12(CASP13)ELISA kit |
GA-E0794MS-96T |
GenAsia Biotech |
96T |
EUR 534 |
Mouse Caspase 12 (CASP12) ELISA Kit |
RD-CASP12-Mu-48Tests |
Reddot Biotech |
48 Tests |
EUR 489 |
Mouse Caspase 12 (CASP12) ELISA Kit |
RD-CASP12-Mu-96Tests |
Reddot Biotech |
96 Tests |
EUR 677 |
Rat Casp12/ Caspase-12 ELISA Kit |
E0156Ra |
Sunlong |
1 Kit |
EUR 571 |
Mouse Casp12/ Caspase-12 ELISA Kit |
E0211Mo |
Sunlong |
1 Kit |
EUR 571 |
Guinea Pig Caspase-12 ELISA Kit |
EGC0697 |
Abclonal |
96Tests |
EUR 521 |
Mouse Caspase 12 (CASP12) ELISA Kit |
RDR-CASP12-Mu-48Tests |
Reddot Biotech |
48 Tests |
EUR 511 |
Mouse Caspase 12 (CASP12) ELISA Kit |
RDR-CASP12-Mu-96Tests |
Reddot Biotech |
96 Tests |
EUR 709 |
The position of BNIP3 in BECN1 dissociation from BCL2 was additional confirmed by BNIP3 overexpression or BNIP3 RNAi. Taken collectively, the endothelial protecting impact of metformin below hyperglycemia circumstances could possibly be partly attributed to its position in downregulating autophagy by way of Hh pathway activation. Abbreviations: 3-MA = 3-methyladenine; 8×GLI BS-FL = 8×GLI-binding website firefly luciferase; AAV = adeno-associated virus; AAV-Cdh5-sh-Atg7 = AAV vectors carrying shRNA in opposition to murine Atg7 below management of murine Cdh5 promoter.