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December 11, 2020

Temporal Patterns of Blood Biomarker candidates of Cardiac Remodeling in Relation to Prognosis of Patients With Chronic Heart Failure-The Bio- SH i FT Study.

By Dylan

Background Transforming biomarkers carry excessive potential for predicting hostile occasions in persistent coronary heart failure ( CHF ) sufferers. Nonetheless, temporal patterns throughout the course of CHF , and particularly the trajectory earlier than an hostile occasion, are unknown. We studied the prognostic worth of temporal patterns of cardiac reworking biomarker candidates in steady sufferers with CHF from the Bio-SHiFT (Serial Biomarker Measurements and New Echocardiographic Methods in Persistent Coronary heart Failure Sufferers End in Tailor-made Prediction of Prognosis) research. Strategies and Outcomes In 263 CHF sufferers, we carried out trimonthly blood sampling throughout a median follow-up of two.2 years.

For the evaluation, we chosen all baseline samples, the two samples closest to the first finish level ( PE ), or the final pattern out there for finish point-free sufferers. Thus, in 567 samples, we measured suppression of tumorigenicity-2, galectin-3, galectin-4, progress differentiation factor-15, matrix metalloproteinase-2, 3, and 9, tissue inhibitor metalloproteinase-4, perlecan, aminopeptidase-N, <em>caspase</em>-3, cathepsin-D, cathepsin-Z, and cystatin-B. The PE was a composite of cardiovascular mortality, coronary heart transplantation, left ventricular help machine implantation, and HF hospitalization. Associations between repeatedly measured biomarker candidates and the PE had been investigated by joint modeling. Median age was 68 (interquartile vary: 59-76) years with 72% males; 70 sufferers reached the PE . Repeatedly measured suppression of tumorigenicity-2, galectin-3, galectin-4, progress differentiation factor-15, matrix metalloproteinase-2 and 9, tissue inhibitor metalloproteinase-4, perlecan, cathepsin-D, and cystatin-B ranges had been considerably related to the PE , and elevated because the PE approached. The slopes of biomarker trajectories had been additionally predictors of scientific end result, impartial of their absolute stage. Associations continued after adjustment for scientific traits and pharmacological therapy.

Suppression of tumorigenicity-2 was the strongest predictor (hazard ratio: 7.55 per SD distinction, 95% CI : 5.53-10.30), adopted by progress differentiation factor-15 and matrix metalloproteinase-2. Conclusions Temporal patterns of reworking biomarker candidates predict hostile scientific outcomes in CHF. JNK and its downstream transcriptional elements together with c-Jun, activating transcription issue 2 (ATF2), and JunD had been all considerably phosphorylated in CIH rats. Nonetheless, pretreatment of NF-κB inhibitor BAY 11-7082 inhibited the activation of NF-κB below CIH situation and likewise considerably decreased the phosphorylation of JNK in addition to c-Jun, ATF2, and JunD.

 

Novel compound VB-037 inhibits Aβ aggregation and promotes neurite outgrowth via enhancement of HSP27 and discount of P38 and JNK-mediated irritation in cell fashions for Alzheimer’s illness.

The pathogenesis of Alzheimer’s illness (AD) is concerned within the aggregation of misfolded amyloid β (Aβ), which upregulates the exercise of acetylcholinesterase (AChE), will increase the manufacturing of reactive oxygen species (ROS), enhances neuroinflammation, and finally results in neuronal dying. Due to this fact, compounds concentrating on these mechanisms could also be candidates for multitarget medication in AD therapy. We discovered that two quinoline derivatives, VB-030 and VB-037, markedly decreased Aβ aggregation and ROS ranges within the thioflavin T biochemical assay and Tet-On Aβ-green fluorescent protein (GFP) 293 AD cell mannequin. These compounds additional improved neurite outgrowth, decreased AChE exercise and upregulated the molecular chaperone warmth shock protein household B [small] member 1 (HSP27), whereas knockdown of HSP27 counteracted the compounds’ neuroprotective results on the Tet-On neuronal mannequin. Moreover, VB-037 attenuated lipopolysaccharide (LPS)/interferon (IFN)-γ-induced activation of BV-2 microglial cells.
As well as, VB-037 demonstrated its potential to decrease LPS/IFN-γ-induced upregulation of <em>caspase</em> 1 exercise, expression of interleukin (IL)-1β, and lively phosphorylation of mitogen-activated protein kinase <em>14</em> (P38), mitogen-activated protein kinase 8 (JNK), and Jun proto-oncogene, AP-1 transcription issue subunit (JUN) signalings, in addition to enhance cell viability within the Tet-On neuronal mannequin. Our findings strongly point out the potential of VB-037 for modifying AD development by concentrating on a number of mechanisms, thereby providing a brand new drug improvement avenue for AD therapy. Hepatitis B virus X (HBx), a viral onco-protein encoded by HBV, can promote oncogenesis of HCC. Nonetheless, the mechanism of HBx in hepatocarcinogenesis remains to be unclear. On this research, we set up a brand new mouse mannequin with regular immune system to analyze the position of HBx and its purposeful mechanisms below regular immune operate.
The animal mannequin was established by injecting HBx-EGFP-<em>14</em>-19 cells into the hepatic portal vein of KM mice. To confirm the mouse mannequin, the expression of HBx within the liver tissue of mice was detected by qRT-PCR, western blotting and immunohistochemistry. The apoptosis index was calculated utilizing the terminal deoxynucleotidyl transferase-dUTP nick-end labeling (TUNEL) assay, and the expression ranges of apoptosis-related and cell cycle-related elements had been measured.

Metformin alleviates hyperglycemia-induced endothelial impairment by downregulating autophagy by way of the Hedgehog pathway.

Research relating to macroautophagic/autophagic regulation in endothelial cells (ECs) below diabetic circumstances are very restricted. Medical proof establishes an endothelial protecting impact of metformin, however the underlying mechanisms stay unclear. We aimed to analyze whether or not metformin exerts its protecting position in opposition to hyperglycemia-induced endothelial impairment via the autophagy equipment. db/db mice had been handled with intravitreal metformin injections. Human umbilical vein endothelial cells (HUVECs) had been cultured both in regular glucose (NG, 5.5 mM) or excessive glucose (HG, 33 mM) medium within the presence or absence of metformin for 72 h. We noticed an apparent inhibition of hyperglycemia-triggered autophagosome synthesis in each the diabetic retinal vasculature and cultured HUVECs by metformin, together with restoration of hyperglycemia-impaired Hedgehog (Hh) pathway exercise.
Particularly, deletion of ATG7 in retinal vascular ECs of db/db mice and cultured HUVECs indicated a detrimental position of autophagy in hyperglycemia-induced endothelial dysfunction. Pretreatment with GANT61, a Hh pathway inhibitor, abolished the metformin-mediated downregulation of autophagy and endothelial protecting motion. Moreover, GLI-family (transcription elements of the Hh pathway) knockdown in HUVECs and retinal vasculature revealed that downregulation of hyperglycemia-activated autophagy by the metformin-mediated Hh pathway activation was GLI1 dependent. Mechanistically, GLI1 knockdown-triggered autophagy was associated to upregulation of BNIP3, which subsequently disrupted the affiliation of BECN1/Beclin 1 and BCL2.

Anti-Caspase-12 Antibody
A04700 100ug
EUR 565.2
Description: Rabbit Polyclonal Caspase-12 Antibody. Validated in IHC, WB and tested in Human, Mouse, Rat.

Anti-Caspase 12 antibody
PAab01286 100 ug
EUR 426

Anti-Caspase-12/CASP12 Antibody
PA2103 100ug/vial
EUR 400.8

Caspase 12 antibody
70R-51166 100 ul
EUR 292.8
Description: Purified Polyclonal Caspase 12 antibody

Caspase 12 antibody
70R-11740 100 ug
EUR 552
Description: Rabbit polyclonal Caspase 12 antibody

Caspase-12 Antibody
2325-002mg 0.02 mg
EUR 206.18
Description: Caspase-12 Antibody: Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.

Caspase-12 Antibody
2325-01mg 0.1 mg
EUR 523.7
Description: Caspase-12 Antibody: Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.

Caspase-12 Antibody
2327-002mg 0.02 mg
EUR 206.18
Description: Caspase-12 Antibody: Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta.

Caspase-12 Antibody
2327-01mg 0.1 mg
EUR 523.7
Description: Caspase-12 Antibody: Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta.

Caspase-12 Antibody
24119-100ul 100ul
EUR 468

Caspase-12 Antibody
24120-100ul 100ul
EUR 468

Caspase 12 antibody
20R-1513 100 ug
EUR 807.6
Description: Rabbit polyclonal Caspase 12 antibody

Caspase-12 Antibody
R31215 100 ug
EUR 419

Caspase 12 Antibody
R36146-100UG 100 ug
EUR 399

Caspase-12 Antibody
F41865-0.08ML 0.08 ml
EUR 165

Caspase-12 Antibody
F41865-0.4ML 0.4 ml
EUR 379

Caspase-12 Antibody
3282-100 each
EUR 424.8

Caspase-12 Antibody
3282-30T each
EUR 175.2

Human cysteinyl aspartate specific proteinases 12,Caspase-12 ELISA Kit
201-12-0763 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Caspase-12
RA15048 100 ug
EUR 553.2

Anti-Caspase 12 (aa232-244) antibody
STJ72856 100 µg
EUR 430.8

Rabbit Polyclonal antibody Anti-CRBN
Anti-CRBN 50 µg
EUR 418.8

Caspase 12 Polyclonal Antibody
ABP50853-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Caspase 12 from Human. This Caspase 12 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Caspase12

Caspase 12 Polyclonal Antibody
ABP50853-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Caspase 12 from Human. This Caspase 12 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Caspase12

Caspase 12 Polyclonal Antibody
ABP50853-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Caspase 12 from Human. This Caspase 12 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Caspase12

Caspase-12 Antibody (Large)
24208-100ul 100ul
EUR 468

Caspase-12 Antibody (Small)
24209-100ul 100ul
EUR 468

Caspase-12 Antibody (Large)
3195-002mg 0.02 mg
EUR 206.18
Description: Caspase-12 Antibody: (Large)Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.

Caspase-12 Antibody (Large)
3195-01mg 0.1 mg
EUR 523.7
Description: Caspase-12 Antibody: (Large)Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.

Caspase-12 Antibody (Small)
3197-002mg 0.02 mg
EUR 206.18
Description: Caspase-12 Antibody: (Small)Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.

Caspase-12 Antibody (Small)
3197-01mg 0.1 mg
EUR 523.7
Description: Caspase-12 Antibody: (Small)Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.

Caspase 12 (CASP12) Antibody
20-abx100899
  • EUR 510.00
  • EUR 159.60
  • EUR 1412.40
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Caspase 12 (CASP12) Antibody
20-abx111421
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Caspase 12 (CASP12) Antibody
20-abx129818
  • EUR 493.20
  • EUR 159.60
  • EUR 1362.00
  • EUR 661.20
  • EUR 376.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Caspase 12 (CASP12) Antibody
abx026563-400ul 400 ul
EUR 627.6

Caspase 12 (CASP12) Antibody
abx026563-80l 80 µl
EUR 343.2

Caspase 12 (CASP12) Antibody
20-abx210324
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Caspase 12 (CASP12) Antibody
20-abx324638
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Caspase 12 (CASP12) Antibody
20-abx318255
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Caspase 12 (Casp12) Antibody
20-abx318989
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Caspase 12 (CASP12) Antibody
abx216233-100ug 100 ug
EUR 526.8

Caspase 12 (CASP12) Antibody
20-abx213378
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Polyclonal Caspase-12 Antibody
APR06275G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 . This antibody is tested and proven to work in the following applications:

Polyclonal Caspase-12 Antibody
APR06276G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 . This antibody is tested and proven to work in the following applications:

Polyclonal Caspase-12 Antibody
APR00058G 0.1mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 . This antibody is tested and proven to work in the following applications:

Caspase-12 Peptide
2325P 0.05 mg
EUR 197.7
Description: (NT) Caspase-12 peptide

Caspase-12 Peptide
2327P 0.05 mg
EUR 197.7
Description: (IN) Caspase-12 peptide

Caspase 12 (Casp12) Antibody (HRP)
20-abx318990
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Caspase 12 (Casp12) Antibody (FITC)
20-abx318991
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Caspase 12 (Casp12) Antibody (Biotin)
20-abx318992
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Caspase 12 (CASP12) Antibody (HRP)
20-abx316303
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Caspase 12 (CASP12) Antibody (FITC)
20-abx316304
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Caspase 12 (CASP12) Antibody (Biotin)
20-abx316305
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Polyclonal Caspase-12 Antibody (Large)
APR06327G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 (Large). This antibody is tested and proven to work in the following applications:

Polyclonal Caspase-12 Antibody (Small)
APR06328G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 (Small). This antibody is tested and proven to work in the following applications:

Rabbit Anti Caspase-12 (Aa100-116) Polyclonal Antibody
CPBT-66303RC 0.1 mg
EUR 696

Caspase 12 Assay Kit
55R-1290 25 assays
EUR 393.6
Description: Assay Kit for detection of Capase 12 activity in the research laboratory

Caspase 12 Blocking Peptide
33R-10465 50 ug
EUR 418.8
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Caspase 12 antibody, catalog no. 20R-1513

Caspase 12 Blocking Peptide
33R-10701 50 ug
EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Caspase 12 antibody, catalog no. 70R-11740

Caspase-12 Peptide (Large)
3195P 0.05 mg
EUR 197.7
Description: Caspase-12 peptide (Large)

Caspase-12 Peptide (Small)
3197P 0.05 mg
EUR 197.7
Description: Caspase-12 peptide (Small)

Caspase 12 Blocking Peptide
20-abx064041
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

Caspase-12 Rabbit pAb
A0217-100ul 100 ul
EUR 369.6

Caspase-12 Rabbit pAb
A0217-200ul 200 ul
EUR 550.8

Caspase-12 Rabbit pAb
A0217-20ul 20 ul
EUR 219.6

Caspase-12 Rabbit pAb
A0217-50ul 50 ul
EUR 267.6

Recombinant Caspase 12 (CASP12)
4-RPA682Mu01
  • EUR 560.83
  • EUR 273.60
  • EUR 1773.12
  • EUR 671.04
  • EUR 1222.08
  • EUR 451.20
  • EUR 4252.80
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Caspase 12 expressed in: E.coli

Recombinant Caspase 12 (CASP12)
4-RPA682Ra01
  • EUR 593.09
  • EUR 282.00
  • EUR 1894.08
  • EUR 711.36
  • EUR 1302.72
  • EUR 472.80
  • EUR 4555.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Caspase 12 expressed in: E.coli

Caspase-12 Blocking Peptide
3282BP-50 each
EUR 183.6

99445-12 DCT 12 X 75MM
99445-12 250/pk
EUR 80.4
Description: Disposable Culture Tubes; DCT's, CGW

Human Caspase 12,Casp-12 ELISA Kit
CN-03708H1 96T
EUR 583.2

Human Caspase 12,Casp-12 ELISA Kit
CN-03708H2 48T
EUR 403.2

Caspase 12 (CASP12) Polyclonal Antibody (Mouse)
4-PAA682Mu01
  • EUR 283.20
  • EUR 2805.60
  • EUR 703.20
  • EUR 352.80
  • EUR 250.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12)

Human Caspase 12 ELISA kit
E01C0690-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Caspase 12 ELISA kit
E01C0690-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Caspase 12 ELISA kit
E01C0690-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Caspase 12 ELISA kit
E02C0690-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Caspase 12 ELISA kit
E02C0690-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rat Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Caspase 12 ELISA kit
E02C0690-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rat Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Caspase 12 ELISA kit
E07C0690-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Caspase 12 ELISA kit
E07C0690-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Caspase 12 ELISA kit
E07C0690-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Caspase 12 ELISA kit
E06C0690-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Goat Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Caspase 12 ELISA kit
E06C0690-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Goat Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Caspase 12 ELISA kit
E06C0690-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Goat Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Caspase 12 ELISA kit
E04C0690-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rabbit Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Caspase 12 ELISA kit
E04C0690-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rabbit Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Caspase 12 ELISA kit
E04C0690-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rabbit Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Caspase 12 ELISA kit
E08C0690-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Caspase 12 ELISA kit
E08C0690-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Canine Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Caspase 12 ELISA kit
E08C0690-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Canine Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Caspase 12 ELISA kit
E09C0690-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Monkey Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Caspase 12 ELISA kit
E09C0690-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Monkey Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Caspase 12 ELISA kit
E09C0690-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Monkey Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Caspase 12 ELISA kit
E03C0690-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Caspase 12 ELISA kit
E03C0690-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Caspase 12 ELISA kit
E03C0690-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Caspase-12 ELISA Kit
EMC0697 96Tests
EUR 625.2

Human Caspase-12 ELISA Kit
EHC0697 96Tests
EUR 625.2

Rat Caspase-12 ELISA Kit
ERC0697 96Tests
EUR 625.2

Rabbit Caspase-12 ELISA Kit
ERTC0697 96Tests
EUR 625.2

Porcine Caspase-12 ELISA Kit
EPC0697 96Tests
EUR 625.2

Mouse Caspase 12 (CASP12) Protein
20-abx167225
  • EUR 777.60
  • EUR 326.40
  • EUR 2397.60
  • EUR 927.60
  • EUR 560.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Rat Caspase 12 (CASP12) Protein
20-abx065753
  • EUR 828.00
  • EUR 343.20
  • EUR 2548.80
  • EUR 978.00
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Goat Caspase-12 ELISA Kit
EGTC0697 96Tests
EUR 625.2

Bovine Caspase-12 ELISA Kit
EBC0697 96Tests
EUR 625.2

Canine Caspase-12 ELISA Kit
ECC0697 96Tests
EUR 625.2

Caspase-12 Fluorometric Assay Kit
K2150-100 100 assays
EUR 634.8

Caspase-12 Fluorometric Assay Kit
K2150-25 25 assays
EUR 301.2

Anserini Caspase-12 ELISA Kit
EAC0697 96Tests
EUR 625.2

Caspase 12 ELISA KIT|Human
EF008399 96 Tests
EUR 826.8

Caspase-12 Fluorometric Assay Kit
K139-100 each
EUR 601.2

Caspase-12 Fluorometric Assay Kit
K139-25 each
EUR 307.2

Caspase-12 Substrate ATAD-AFC
1117-1000 each
EUR 1305.6

Caspase-12 Substrate ATAD-AFC
1117-200 each
EUR 523.2

Caspase 12 (CASP12) Polyclonal Antibody (Mouse), APC
4-PAA682Mu01-APC
  • EUR 394.80
  • EUR 3649.20
  • EUR 1024.80
  • EUR 499.20
  • EUR 254.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with APC.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse), Biotinylated
4-PAA682Mu01-Biotin
  • EUR 358.80
  • EUR 2745.60
  • EUR 820.80
  • EUR 435.60
  • EUR 256.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with Biotin.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse), Cy3
4-PAA682Mu01-Cy3
  • EUR 476.40
  • EUR 4815.60
  • EUR 1316.40
  • EUR 615.60
  • EUR 289.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with Cy3.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse), FITC
4-PAA682Mu01-FITC
  • EUR 339.60
  • EUR 2942.40
  • EUR 843.60
  • EUR 423.60
  • EUR 226.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with FITC.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse), HRP
4-PAA682Mu01-HRP
  • EUR 362.40
  • EUR 3182.40
  • EUR 907.20
  • EUR 452.40
  • EUR 240.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with HRP.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse), PE
4-PAA682Mu01-PE
  • EUR 339.60
  • EUR 2942.40
  • EUR 843.60
  • EUR 423.60
  • EUR 226.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with PE.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse, Rat)
4-PAA682Ra01
  • EUR 291.60
  • EUR 2948.40
  • EUR 735.60
  • EUR 366.00
  • EUR 254.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse, Rat Caspase 12 (CASP12)

Individual Reaction Mix 12
G065-12 200 reactions
EUR 200.4

Human 12-lipoxygenase,LOX-12 ELISA Kit
201-12-0949 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Rat Casp12/ Caspase-12 ELISA Kit
E0156Ra 1 Kit
EUR 685.2

Mouse Casp12/ Caspase-12 ELISA Kit
E0211Mo 1 Kit
EUR 685.2

Guinea pig Caspase 12 ELISA kit
E05C0690-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Guinea pig Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Caspase 12 ELISA kit
E05C0690-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Guinea pig Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Caspase 12 ELISA kit
E05C0690-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Guinea pig Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Casp12(Caspase-12) ELISA Kit
EM0436 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.094 ng/ml

ELISA kit for Mouse Caspase-12
EK2112 96 tests
EUR 663.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse Caspase-12 in samples from serum, plasma, tissue homogenates and other biological fluids.

ELISA kit for Human Caspase-12
EK2113 96 tests
EUR 663.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Caspase-12 in samples from serum, plasma, tissue homogenates and other biological fluids.

ELISA kit for Rat Caspase-12
EK2114 96 tests
EUR 663.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Rat Caspase-12 in samples from serum, plasma, tissue homogenates and other biological fluids.

Rat Casp12(Caspase 12) ELISA Kit
ER0345 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 0.094 ng/ml

CaspGLOW Active Caspase 12 Staining Kit
55R-1291 25 assays
EUR 338.4
Description: Caspase 12 Staining Kit for use activity in the research laboratory

Human Caspase 12 (CASP12) CLIA Kit
abx196504-96tests 96 tests
EUR 990

Rat Caspase 12 (CASP12) CLIA Kit
abx196787-96tests 96 tests
EUR 990

Rat Caspase 12 (CASP12) ELISA Kit
abx353550-96tests 96 tests
EUR 943.2

Human Caspase 12 (CASP12) ELISA Kit
20-abx259273
  • EUR 7970.40
  • EUR 4250.40
  • EUR 990.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Caspase 12 (CASP12) ELISA Kit
abx358592-96tests 96 tests
EUR 848.4

Human Caspase 12 (CASP12) ELISA Kit
abx513694-96tests 96 tests
EUR 848.4

Mouse Caspase 12 (CASP12) CLIA Kit
20-abx491877
  • EUR 9567.60
  • EUR 5095.20
  • EUR 1177.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Rat Caspase 12 (CASP12) ELISA Kit
abx256323-96tests 96 tests
EUR 943.2

Mouse Caspase 12 (CASP12) ELISA Kit
20-abx258452
  • EUR 8853.60
  • EUR 4719.60
  • EUR 1093.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests
The position of BNIP3 in BECN1 dissociation from BCL2 was additional confirmed by BNIP3 overexpression or BNIP3 RNAi. Taken collectively, the endothelial protecting impact of metformin below hyperglycemia circumstances could possibly be partly attributed to its position in downregulating autophagy by way of Hh pathway activation. Abbreviations: 3-MA = 3-methyladenine; 8×GLI BS-FL = 8×GLI-binding website firefly luciferase; AAV = adeno-associated virus; AAV-Cdh5-sh-Atg7 = AAV vectors carrying shRNA in opposition to murine Atg7 below management of murine Cdh5 promoter.

 

 

 

 

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