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December 11, 2020

Temporal Patterns of Blood Biomarker candidates of Cardiac Remodeling in Relation to Prognosis of Patients With Chronic Heart Failure-The Bio- SH i FT Study.

By Dylan

Background Transforming biomarkers carry excessive potential for predicting hostile occasions in persistent coronary heart failure ( CHF ) sufferers. Nonetheless, temporal patterns throughout the course of CHF , and particularly the trajectory earlier than an hostile occasion, are unknown. We studied the prognostic worth of temporal patterns of cardiac reworking biomarker candidates in steady sufferers with CHF from the Bio-SHiFT (Serial Biomarker Measurements and New Echocardiographic Methods in Persistent Coronary heart Failure Sufferers End in Tailor-made Prediction of Prognosis) research. Strategies and Outcomes In 263 CHF sufferers, we carried out trimonthly blood sampling throughout a median follow-up of two.2 years.

For the evaluation, we chosen all baseline samples, the two samples closest to the first finish level ( PE ), or the final pattern out there for finish point-free sufferers. Thus, in 567 samples, we measured suppression of tumorigenicity-2, galectin-3, galectin-4, progress differentiation factor-15, matrix metalloproteinase-2, 3, and 9, tissue inhibitor metalloproteinase-4, perlecan, aminopeptidase-N, <em>caspase</em>-3, cathepsin-D, cathepsin-Z, and cystatin-B. The PE was a composite of cardiovascular mortality, coronary heart transplantation, left ventricular help machine implantation, and HF hospitalization. Associations between repeatedly measured biomarker candidates and the PE had been investigated by joint modeling. Median age was 68 (interquartile vary: 59-76) years with 72% males; 70 sufferers reached the PE . Repeatedly measured suppression of tumorigenicity-2, galectin-3, galectin-4, progress differentiation factor-15, matrix metalloproteinase-2 and 9, tissue inhibitor metalloproteinase-4, perlecan, cathepsin-D, and cystatin-B ranges had been considerably related to the PE , and elevated because the PE approached. The slopes of biomarker trajectories had been additionally predictors of scientific end result, impartial of their absolute stage. Associations continued after adjustment for scientific traits and pharmacological therapy.

Suppression of tumorigenicity-2 was the strongest predictor (hazard ratio: 7.55 per SD distinction, 95% CI : 5.53-10.30), adopted by progress differentiation factor-15 and matrix metalloproteinase-2. Conclusions Temporal patterns of reworking biomarker candidates predict hostile scientific outcomes in CHF. JNK and its downstream transcriptional elements together with c-Jun, activating transcription issue 2 (ATF2), and JunD had been all considerably phosphorylated in CIH rats. Nonetheless, pretreatment of NF-κB inhibitor BAY 11-7082 inhibited the activation of NF-κB below CIH situation and likewise considerably decreased the phosphorylation of JNK in addition to c-Jun, ATF2, and JunD.

 

Novel compound VB-037 inhibits Aβ aggregation and promotes neurite outgrowth via enhancement of HSP27 and discount of P38 and JNK-mediated irritation in cell fashions for Alzheimer’s illness.

The pathogenesis of Alzheimer’s illness (AD) is concerned within the aggregation of misfolded amyloid β (Aβ), which upregulates the exercise of acetylcholinesterase (AChE), will increase the manufacturing of reactive oxygen species (ROS), enhances neuroinflammation, and finally results in neuronal dying. Due to this fact, compounds concentrating on these mechanisms could also be candidates for multitarget medication in AD therapy. We discovered that two quinoline derivatives, VB-030 and VB-037, markedly decreased Aβ aggregation and ROS ranges within the thioflavin T biochemical assay and Tet-On Aβ-green fluorescent protein (GFP) 293 AD cell mannequin. These compounds additional improved neurite outgrowth, decreased AChE exercise and upregulated the molecular chaperone warmth shock protein household B [small] member 1 (HSP27), whereas knockdown of HSP27 counteracted the compounds’ neuroprotective results on the Tet-On neuronal mannequin. Moreover, VB-037 attenuated lipopolysaccharide (LPS)/interferon (IFN)-γ-induced activation of BV-2 microglial cells.
As well as, VB-037 demonstrated its potential to decrease LPS/IFN-γ-induced upregulation of <em>caspase</em> 1 exercise, expression of interleukin (IL)-1β, and lively phosphorylation of mitogen-activated protein kinase <em>14</em> (P38), mitogen-activated protein kinase 8 (JNK), and Jun proto-oncogene, AP-1 transcription issue subunit (JUN) signalings, in addition to enhance cell viability within the Tet-On neuronal mannequin. Our findings strongly point out the potential of VB-037 for modifying AD development by concentrating on a number of mechanisms, thereby providing a brand new drug improvement avenue for AD therapy. Hepatitis B virus X (HBx), a viral onco-protein encoded by HBV, can promote oncogenesis of HCC. Nonetheless, the mechanism of HBx in hepatocarcinogenesis remains to be unclear. On this research, we set up a brand new mouse mannequin with regular immune system to analyze the position of HBx and its purposeful mechanisms below regular immune operate.
The animal mannequin was established by injecting HBx-EGFP-<em>14</em>-19 cells into the hepatic portal vein of KM mice. To confirm the mouse mannequin, the expression of HBx within the liver tissue of mice was detected by qRT-PCR, western blotting and immunohistochemistry. The apoptosis index was calculated utilizing the terminal deoxynucleotidyl transferase-dUTP nick-end labeling (TUNEL) assay, and the expression ranges of apoptosis-related and cell cycle-related elements had been measured.

Metformin alleviates hyperglycemia-induced endothelial impairment by downregulating autophagy by way of the Hedgehog pathway.

Research relating to macroautophagic/autophagic regulation in endothelial cells (ECs) below diabetic circumstances are very restricted. Medical proof establishes an endothelial protecting impact of metformin, however the underlying mechanisms stay unclear. We aimed to analyze whether or not metformin exerts its protecting position in opposition to hyperglycemia-induced endothelial impairment via the autophagy equipment. db/db mice had been handled with intravitreal metformin injections. Human umbilical vein endothelial cells (HUVECs) had been cultured both in regular glucose (NG, 5.5 mM) or excessive glucose (HG, 33 mM) medium within the presence or absence of metformin for 72 h. We noticed an apparent inhibition of hyperglycemia-triggered autophagosome synthesis in each the diabetic retinal vasculature and cultured HUVECs by metformin, together with restoration of hyperglycemia-impaired Hedgehog (Hh) pathway exercise.
Particularly, deletion of ATG7 in retinal vascular ECs of db/db mice and cultured HUVECs indicated a detrimental position of autophagy in hyperglycemia-induced endothelial dysfunction. Pretreatment with GANT61, a Hh pathway inhibitor, abolished the metformin-mediated downregulation of autophagy and endothelial protecting motion. Moreover, GLI-family (transcription elements of the Hh pathway) knockdown in HUVECs and retinal vasculature revealed that downregulation of hyperglycemia-activated autophagy by the metformin-mediated Hh pathway activation was GLI1 dependent. Mechanistically, GLI1 knockdown-triggered autophagy was associated to upregulation of BNIP3, which subsequently disrupted the affiliation of BECN1/Beclin 1 and BCL2.

Caspase 12 antibody
70R-11740 100 ug
EUR 552
Description: Rabbit polyclonal Caspase 12 antibody

Caspase 12 antibody
70R-51166 100 ul
EUR 292.8
Description: Purified Polyclonal Caspase 12 antibody

Caspase 12 antibody
20R-1513 100 ug
EUR 807.6
Description: Rabbit polyclonal Caspase 12 antibody

Caspase 12 Antibody
R36146-100UG 100 ug
EUR 339.15
Description: Additional name(s) for this target protein: CASP12

Caspase-12 Antibody
2325-002mg 0.02 mg
EUR 206.18
Description: Caspase-12 Antibody: Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.

Caspase-12 Antibody
2325-01mg 0.1 mg
EUR 523.7
Description: Caspase-12 Antibody: Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.

Caspase-12 Antibody
2327-002mg 0.02 mg
EUR 206.18
Description: Caspase-12 Antibody: Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta.

Caspase-12 Antibody
2327-01mg 0.1 mg
EUR 523.7
Description: Caspase-12 Antibody: Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta.

Caspase-12 Antibody
24119-100ul 100ul
EUR 468

Caspase-12 Antibody
24120-100ul 100ul
EUR 468

Caspase-12 Antibody
3282-100 each
EUR 424.8

Caspase-12 Antibody
3282-30T each
EUR 175.2

Caspase-12 Antibody
F41865-0.08ML 0.08 ml
EUR 140.25
Description: Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene.

Caspase-12 Antibody
F41865-0.4ML 0.4 ml
EUR 322.15
Description: Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene.

Caspase-12 Antibody
R31215 100 ug
EUR 356.15
Description: Caspase-12 is an enzyme known as a cysteine protease. It belongs to a family of enzymes called caspases that cleave their substrates at C-terminal aspartic acid residues. The CASP12 gene was mapped to chromosome 11q22.3. Caspase-12 attenuates the inflammatory and innate immune response to endotoxins and in doing so may constitute a risk factor for developing sepsis. The estrogen-mediated inhibition of its expression is a built-in mechanism that has evolved to protect females from infection by favoring a more robust inflammatory response to pathogens, perhaps notably in childbirth.

Caspase-12 Antibody (Large)
24208-100ul 100ul
EUR 468

Caspase-12 Antibody (Small)
24209-100ul 100ul
EUR 468

Caspase-12 Antibody (Large)
3195-002mg 0.02 mg
EUR 206.18
Description: Caspase-12 Antibody: (Large)Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.

Caspase-12 Antibody (Large)
3195-01mg 0.1 mg
EUR 523.7
Description: Caspase-12 Antibody: (Large)Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.

Caspase-12 Antibody (Small)
3197-002mg 0.02 mg
EUR 206.18
Description: Caspase-12 Antibody: (Small)Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.

Caspase-12 Antibody (Small)
3197-01mg 0.1 mg
EUR 523.7
Description: Caspase-12 Antibody: (Small)Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.

Polyclonal Caspase-12 Antibody
APR06275G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 . This antibody is tested and proven to work in the following applications:

Polyclonal Caspase-12 Antibody
APR06276G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 . This antibody is tested and proven to work in the following applications:

Polyclonal Caspase-12 Antibody
APR00058G 0.1mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 . This antibody is tested and proven to work in the following applications:

Caspase 12 (CASP12) Antibody
abx216233-100ug 100 ug
EUR 526.8

Caspase 12 (CASP12) Antibody
20-abx213378
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Caspase 12 (CASP12) Antibody
20-abx100899
  • EUR 510.00
  • EUR 159.60
  • EUR 1412.40
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Caspase 12 (CASP12) Antibody
20-abx318255
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Caspase 12 (Casp12) Antibody
20-abx318989
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Caspase 12 (CASP12) Antibody
20-abx324638
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Caspase 12 (CASP12) Antibody
20-abx111421
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Caspase 12 (CASP12) Antibody
20-abx210324
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Caspase 12 (CASP12) Antibody
20-abx129818
  • EUR 493.20
  • EUR 159.60
  • EUR 1362.00
  • EUR 661.20
  • EUR 376.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Caspase 12 (CASP12) Antibody
abx026563-400ul 400 ul
EUR 627.6

Caspase 12 (CASP12) Antibody
abx026563-80l 80 µl
EUR 343.2

Caspase 12 Polyclonal Antibody
ABP50853-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Caspase 12 from Human. This Caspase 12 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Caspase12

Caspase 12 Polyclonal Antibody
ABP50853-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Caspase 12 from Human. This Caspase 12 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Caspase12

Caspase 12 Polyclonal Antibody
ABP50853-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Caspase 12 from Human. This Caspase 12 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Caspase12

Caspase 12 (CASP12) Antibody (HRP)
20-abx316303
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Caspase 12 (Casp12) Antibody (HRP)
20-abx318990
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Polyclonal Caspase-12 Antibody (Large)
APR06327G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 (Large). This antibody is tested and proven to work in the following applications:

Polyclonal Caspase-12 Antibody (Small)
APR06328G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 (Small). This antibody is tested and proven to work in the following applications:

Caspase 12 (CASP12) Antibody (FITC)
20-abx316304
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Caspase 12 (Casp12) Antibody (FITC)
20-abx318991
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Caspase 12 (CASP12) Antibody (Biotin)
20-abx316305
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Caspase 12 (Casp12) Antibody (Biotin)
20-abx318992
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Rabbit Anti Caspase-12 (Aa100-116) Polyclonal Antibody
CPBT-66303RC 0.1 mg
EUR 696

anti- Caspase 2 antibody
FNab098281 100µg
EUR 658.5
Description: Antibody raised against Caspase 2

anti- Caspase 3 antibody
FNab10013 100µg
EUR 658.5
Description: Antibody raised against Caspase 3

anti- Caspase 1 antibody
FNab10015 100µg
EUR 658.5
Description: Antibody raised against Caspase 1

anti- Caspase 8 antibody
FNab10024 100µg
EUR 658.5
Description: Antibody raised against Caspase 8

anti- Caspase 1 antibody
FNab01284 100µg
EUR 658.5
Description: Antibody raised against Caspase 1

anti- Caspase 10 antibody
FNab01285 100µg
EUR 606.3
Description: Antibody raised against Caspase 10

anti- Caspase 2 antibody
FNab01287 100µg
EUR 606.3
Description: Antibody raised against Caspase 2

anti- Caspase 2 antibody
FNab01288 100µg
EUR 658.5
Description: Antibody raised against Caspase 2

anti- Caspase 3 antibody
FNab01289 100µg
EUR 606.3
Description: Antibody raised against Caspase 3

anti- Caspase 4 antibody
FNab01291 100µg
EUR 606.3
Description: Antibody raised against Caspase 4

anti- Caspase 6 antibody
FNab01292 100µg
EUR 658.5
Description: Antibody raised against Caspase 6

anti- Caspase 8 antibody
FNab01293 100µg
EUR 606.3
Description: Antibody raised against Caspase 8

anti- Caspase 8 antibody
FNab01294 100µg
EUR 606.3
Description: Antibody raised against Caspase 8

anti- Caspase 9 antibody
FNab01295 100µg
EUR 606.3
Description: Antibody raised against Caspase 9

anti- Caspase 9 antibody
FNab01296 100µg
EUR 606.3
Description: Antibody raised against Caspase 9

anti- Caspase 9 antibody
FNab01297 100µg
EUR 658.5
Description: Antibody raised against Caspase 9

Caspase 12 (CASP12) Polyclonal Antibody (Mouse)
4-PAA682Mu01
  • EUR 283.20
  • EUR 2805.60
  • EUR 703.20
  • EUR 352.80
  • EUR 250.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12)

Caspase 12 (CASP12) Polyclonal Antibody (Mouse), PE
4-PAA682Mu01-PE
  • EUR 339.60
  • EUR 2942.40
  • EUR 843.60
  • EUR 423.60
  • EUR 226.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with PE.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse), APC
4-PAA682Mu01-APC
  • EUR 394.80
  • EUR 3649.20
  • EUR 1024.80
  • EUR 499.20
  • EUR 254.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with APC.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse), Cy3
4-PAA682Mu01-Cy3
  • EUR 476.40
  • EUR 4815.60
  • EUR 1316.40
  • EUR 615.60
  • EUR 289.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with Cy3.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse), HRP
4-PAA682Mu01-HRP
  • EUR 362.40
  • EUR 3182.40
  • EUR 907.20
  • EUR 452.40
  • EUR 240.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with HRP.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse, Rat)
4-PAA682Ra01
  • EUR 291.60
  • EUR 2948.40
  • EUR 735.60
  • EUR 366.00
  • EUR 254.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse, Rat Caspase 12 (CASP12)

Anti-Active Caspase-3 antibody
STJ97448 200 µl
EUR 236.4
Description: Active caspase-3 is a protein encoded by the CASP3 gene which is approximately 31,6 kDa. Active caspase-3 is localised to the cytoplasm. It is involved in the TNFR1 pathway, apoptosis modulation and signalling and respiratory electron transport. This protein falls under the cysteine-aspartic acid protease family. It is a sequential activator of caspases and plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Active caspase-3 is highly expressed in lung, spleen, heart, liver and kidney. Mutations in the CASP3 gene may result in bladder urothelial carcinoma and primary effusion lymphoma. STJ97448 was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. This antibody detects endogenous active caspase-3 protein.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse), FITC
4-PAA682Mu01-FITC
  • EUR 339.60
  • EUR 2942.40
  • EUR 843.60
  • EUR 423.60
  • EUR 226.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with FITC.

Caspase-12
RA15048 100 ug
EUR 553.2

Caspase 12 (CASP12) Polyclonal Antibody (Mouse, Rat), PE
4-PAA682Ra01-PE
  • EUR 350.40
  • EUR 3098.40
  • EUR 882.00
  • EUR 439.20
  • EUR 232.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse, Rat Caspase 12 (CASP12). This antibody is labeled with PE.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse), Biotinylated
4-PAA682Mu01-Biotin
  • EUR 358.80
  • EUR 2745.60
  • EUR 820.80
  • EUR 435.60
  • EUR 256.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with Biotin.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse, Rat), APC
4-PAA682Ra01-APC
  • EUR 408.00
  • EUR 3843.60
  • EUR 1072.80
  • EUR 518.40
  • EUR 260.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse, Rat Caspase 12 (CASP12). This antibody is labeled with APC.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse, Rat), Cy3
4-PAA682Ra01-Cy3
  • EUR 493.20
  • EUR 5074.80
  • EUR 1381.20
  • EUR 642.00
  • EUR 297.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse, Rat Caspase 12 (CASP12). This antibody is labeled with Cy3.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse, Rat), HRP
4-PAA682Ra01-HRP
  • EUR 373.20
  • EUR 3350.40
  • EUR 949.20
  • EUR 469.20
  • EUR 246.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse, Rat Caspase 12 (CASP12). This antibody is labeled with HRP.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse, Rat), FITC
4-PAA682Ra01-FITC
  • EUR 350.40
  • EUR 3098.40
  • EUR 882.00
  • EUR 439.20
  • EUR 232.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse, Rat Caspase 12 (CASP12). This antibody is labeled with FITC.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse), APC-Cy7
4-PAA682Mu01-APC-Cy7
  • EUR 645.60
  • EUR 7154.40
  • EUR 1905.60
  • EUR 855.60
  • EUR 364.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with APC-Cy7.

Caspase 1 Antibody
6687-100 each
EUR 405.6

Caspase 1 Antibody
6687-30T each
EUR 175.2

Caspase 3 antibody
70R-11558 100 ug
EUR 774
Description: Rabbit polyclonal Caspase 3 antibody

Caspase 1 antibody
70R-11561 100 ug
EUR 632.4
Description: Rabbit polyclonal Caspase 1 antibody

Caspase 8 antibody
70R-11562 100 ug
EUR 500.4
Description: Rabbit polyclonal Caspase 8 antibody

Caspase 11 antibody
70R-11563 100 ug
EUR 541.2
Description: Rabbit polyclonal Caspase 11 antibody

Caspase 2 antibody
70R-11565 100 ug
EUR 501.6
Description: Rabbit polyclonal Caspase 2 antibody

Caspase 4 antibody
70R-11566 100 ug
EUR 483.6
Description: Rabbit polyclonal Caspase 4 antibody

Caspase 5 antibody
70R-11567 100 ug
EUR 483.6
Description: Rabbit polyclonal Caspase 5 antibody

Caspase 7 antibody
70R-11635 100 ug
EUR 483.6
Description: Rabbit polyclonal Caspase 7 antibody

Caspase 9 antibody
70R-11636 100 ug
EUR 501.6
Description: Rabbit polyclonal Caspase 9 antibody

Caspase 3 antibody
70R-11638 100 ug
EUR 564
Description: Rabbit polyclonal Caspase 3 antibody

Caspase 8 antibody
70R-11657 100 ug
EUR 483.6
Description: Rabbit polyclonal Caspase 8 antibody

Caspase 6 antibody
70R-11722 100 ug
EUR 483.6
Description: Rabbit polyclonal Caspase 6 antibody

Caspase 9 antibody
70R-11806 100 ug
EUR 483.6
Description: Rabbit polyclonal Caspase 9 antibody

Caspase 10 antibody
70R-11807 200 ug
EUR 501.6
Description: Rabbit polyclonal Caspase 10 antibody

Caspase 4 antibody
70R-12500 100 ul
EUR 548.4
Description: Affinity purified Rabbit polyclonal Caspase 4 antibody

Caspase 8 antibody
70R-12555 100 ul
EUR 548.4
Description: Affinity purified Rabbit polyclonal Caspase 8 antibody

Caspase 14 antibody
70R-13452 100 ul
EUR 548.4
Description: Affinity purified Rabbit polyclonal Caspase 14 antibody

Caspase 9 antibody
70R-13511 100 ul
EUR 548.4
Description: Affinity purified Rabbit polyclonal Caspase 9 antibody

Caspase 2 antibody
70R-13776 100 ug
EUR 386.4
Description: Affinity purified Rabbit polyclonal Caspase 2 antibody

Caspase 3 antibody
70R-13844 100 ug
EUR 386.4
Description: Affinity purified Rabbit polyclonal Caspase 3 antibody

Caspase 8 antibody
70R-13850 100 ug
EUR 386.4
Description: Affinity purified Rabbit polyclonal Caspase 8 antibody

Caspase 5 Antibody
49138-100ul 100ul
EUR 399.6

Caspase 5 Antibody
49138-50ul 50ul
EUR 286.8

Caspase 4 antibody
70R-14029 100 ug
EUR 386.4
Description: Affinity purified Rabbit polyclonal Caspase 4 antibody

Caspase 10 antibody
70R-14052 100 ug
EUR 386.4
Description: Affinity purified Rabbit polyclonal Caspase 10 antibody

Caspase 1 antibody
70R-14061 100 ug
EUR 386.4
Description: Affinity purified Rabbit polyclonal Caspase 1 antibody

Caspase 8 antibody
70R-14063 100 ug
EUR 386.4
Description: Affinity purified Rabbit polyclonal Caspase 8 antibody

Caspase 9 antibody
70R-14132 100 ug
EUR 386.4
Description: Affinity purified Rabbit polyclonal Caspase 9 antibody

Caspase 8 antibody
70R-14272 100 ug
EUR 386.4
Description: Affinity purified Rabbit polyclonal Caspase 8 antibody

Caspase 7 antibody
70R-15287 100 ug
EUR 392.4
Description: Rabbit polyclonal Caspase 7 antibody

Caspase 6 antibody
70R-30655 100 ug
EUR 392.4
Description: Rabbit polyclonal Caspase 6 antibody

Caspase 8 antibody
70R-30657 100 ug
EUR 392.4
Description: Rabbit polyclonal Caspase 8 antibody

Caspase 9 antibody
70R-30659 100 ug
EUR 392.4
Description: Rabbit polyclonal Caspase 9 antibody

Caspase 1 antibody
70R-15367 100 ug
EUR 392.4
Description: Rabbit polyclonal Caspase 1 antibody

Caspase 7 antibody
10R-6717 100 ug
EUR 781.2
Description: Mouse monoclonal Caspase 7 antibody

Caspase 8 antibody
10R-6739 100 ug
EUR 937.2
Description: Mouse monoclonal Caspase 8 antibody

Caspase 4 antibody
10R-6742 100 ug
EUR 846
Description: Mouse monoclonal Caspase 4 antibody

Caspase 3 Antibody
21420-100ul 100ul
EUR 302.4

Caspase 3 Antibody
21420-50ul 50ul
EUR 224.4

Caspase 9 Antibody
21422-100ul 100ul
EUR 302.4

Caspase 9 Antibody
21422-50ul 50ul
EUR 224.4

Caspase 14 antibody
22909-100ul 100ul
EUR 468

Caspase 9 antibody
22978-100ul 100ul
EUR 468

Caspase 1 antibody
70R-35920 100 ug
EUR 392.4
Description: Rabbit polyclonal Caspase 1 antibody

Caspase 9 antibody
70R-33457 100 ug
EUR 392.4
Description: Rabbit polyclonal Caspase 9 antibody

Caspase 9 antibody
70R-33459 100 ug
EUR 392.4
Description: Rabbit polyclonal Caspase 9 antibody

Caspase 9 antibody
70R-33461 100 ug
EUR 392.4
Description: Rabbit polyclonal Caspase 9 antibody

Caspase 3 antibody
70R-33463 100 ug
EUR 392.4
Description: Rabbit polyclonal Caspase 3 antibody

Caspase 2 antibody
70R-35139 100 ug
EUR 392.4
Description: Purified Rabbit polyclonal Caspase 2 antibody

Caspase 1 antibody
70R-49451 100 ul
EUR 292.8
Description: Purified Polyclonal Caspase 1 antibody

Caspase 1 antibody
70R-49452 100 ul
EUR 292.8
Description: Purified Polyclonal Caspase 1 antibody

Caspase 3 antibody
70R-49456 100 ul
EUR 292.8
Description: Purified Polyclonal Caspase 3 antibody

Caspase 3 antibody
70R-49457 100 ul
EUR 292.8
Description: Purified Polyclonal Caspase 3 antibody

Caspase 3 antibody
70R-49458 100 ul
EUR 292.8
Description: Purified Polyclonal Caspase 3 antibody

Caspase 4 antibody
70R-49462 100 ul
EUR 292.8
Description: Purified Polyclonal Caspase 4 antibody

Caspase 7 antibody
70R-49468 100 ul
EUR 292.8
Description: Purified Polyclonal Caspase 7 antibody

Caspase 7 antibody
70R-49470 100 ul
EUR 292.8
Description: Purified Polyclonal Caspase 7 antibody

Caspase 8 antibody
70R-49471 100 ul
EUR 344.4
Description: Purified Polyclonal Caspase 8 antibody

Caspase 8 antibody
70R-49472 100 ul
EUR 344.4
Description: Purified Polyclonal Caspase 8 antibody

Caspase 8 antibody
70R-49473 100 ul
EUR 292.8
Description: Purified Polyclonal Caspase 8 antibody

Caspase 9 antibody
70R-49474 100 ul
EUR 292.8
Description: Purified Polyclonal Caspase 9 antibody

Caspase 9 antibody
70R-49475 100 ul
EUR 292.8
Description: Purified Polyclonal Caspase 9 antibody

Caspase 10 antibody
70R-49476 100 ul
EUR 292.8
Description: Purified Polyclonal Caspase 10 antibody
The position of BNIP3 in BECN1 dissociation from BCL2 was additional confirmed by BNIP3 overexpression or BNIP3 RNAi. Taken collectively, the endothelial protecting impact of metformin below hyperglycemia circumstances could possibly be partly attributed to its position in downregulating autophagy by way of Hh pathway activation. Abbreviations: 3-MA = 3-methyladenine; 8×GLI BS-FL = 8×GLI-binding website firefly luciferase; AAV = adeno-associated virus; AAV-Cdh5-sh-Atg7 = AAV vectors carrying shRNA in opposition to murine Atg7 below management of murine Cdh5 promoter.

 

 

 

 

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