December 11, 2020

Temporal Patterns of Blood Biomarker candidates of Cardiac Remodeling in Relation to Prognosis of Patients With Chronic Heart Failure-The Bio- SH i FT Study.

By Dylan

Background Transforming biomarkers carry excessive potential for predicting hostile occasions in persistent coronary heart failure ( CHF ) sufferers. Nonetheless, temporal patterns throughout the course of CHF , and particularly the trajectory earlier than an hostile occasion, are unknown. We studied the prognostic worth of temporal patterns of cardiac reworking biomarker candidates in steady sufferers with CHF from the Bio-SHiFT (Serial Biomarker Measurements and New Echocardiographic Methods in Persistent Coronary heart Failure Sufferers End in Tailor-made Prediction of Prognosis) research. Strategies and Outcomes In 263 CHF sufferers, we carried out trimonthly blood sampling throughout a median follow-up of two.2 years.

For the evaluation, we chosen all baseline samples, the two samples closest to the first finish level ( PE ), or the final pattern out there for finish point-free sufferers. Thus, in 567 samples, we measured suppression of tumorigenicity-2, galectin-3, galectin-4, progress differentiation factor-15, matrix metalloproteinase-2, 3, and 9, tissue inhibitor metalloproteinase-4, perlecan, aminopeptidase-N, <em>caspase</em>-3, cathepsin-D, cathepsin-Z, and cystatin-B. The PE was a composite of cardiovascular mortality, coronary heart transplantation, left ventricular help machine implantation, and HF hospitalization. Associations between repeatedly measured biomarker candidates and the PE had been investigated by joint modeling. Median age was 68 (interquartile vary: 59-76) years with 72% males; 70 sufferers reached the PE . Repeatedly measured suppression of tumorigenicity-2, galectin-3, galectin-4, progress differentiation factor-15, matrix metalloproteinase-2 and 9, tissue inhibitor metalloproteinase-4, perlecan, cathepsin-D, and cystatin-B ranges had been considerably related to the PE , and elevated because the PE approached. The slopes of biomarker trajectories had been additionally predictors of scientific end result, impartial of their absolute stage. Associations continued after adjustment for scientific traits and pharmacological therapy.

Suppression of tumorigenicity-2 was the strongest predictor (hazard ratio: 7.55 per SD distinction, 95% CI : 5.53-10.30), adopted by progress differentiation factor-15 and matrix metalloproteinase-2. Conclusions Temporal patterns of reworking biomarker candidates predict hostile scientific outcomes in CHF. JNK and its downstream transcriptional elements together with c-Jun, activating transcription issue 2 (ATF2), and JunD had been all considerably phosphorylated in CIH rats. Nonetheless, pretreatment of NF-κB inhibitor BAY 11-7082 inhibited the activation of NF-κB below CIH situation and likewise considerably decreased the phosphorylation of JNK in addition to c-Jun, ATF2, and JunD.

 

Novel compound VB-037 inhibits Aβ aggregation and promotes neurite outgrowth via enhancement of HSP27 and discount of P38 and JNK-mediated irritation in cell fashions for Alzheimer’s illness.

The pathogenesis of Alzheimer’s illness (AD) is concerned within the aggregation of misfolded amyloid β (Aβ), which upregulates the exercise of acetylcholinesterase (AChE), will increase the manufacturing of reactive oxygen species (ROS), enhances neuroinflammation, and finally results in neuronal dying. Due to this fact, compounds concentrating on these mechanisms could also be candidates for multitarget medication in AD therapy. We discovered that two quinoline derivatives, VB-030 and VB-037, markedly decreased Aβ aggregation and ROS ranges within the thioflavin T biochemical assay and Tet-On Aβ-green fluorescent protein (GFP) 293 AD cell mannequin. These compounds additional improved neurite outgrowth, decreased AChE exercise and upregulated the molecular chaperone warmth shock protein household B [small] member 1 (HSP27), whereas knockdown of HSP27 counteracted the compounds’ neuroprotective results on the Tet-On neuronal mannequin. Moreover, VB-037 attenuated lipopolysaccharide (LPS)/interferon (IFN)-γ-induced activation of BV-2 microglial cells.
As well as, VB-037 demonstrated its potential to decrease LPS/IFN-γ-induced upregulation of <em>caspase</em> 1 exercise, expression of interleukin (IL)-1β, and lively phosphorylation of mitogen-activated protein kinase <em>14</em> (P38), mitogen-activated protein kinase 8 (JNK), and Jun proto-oncogene, AP-1 transcription issue subunit (JUN) signalings, in addition to enhance cell viability within the Tet-On neuronal mannequin. Our findings strongly point out the potential of VB-037 for modifying AD development by concentrating on a number of mechanisms, thereby providing a brand new drug improvement avenue for AD therapy. Hepatitis B virus X (HBx), a viral onco-protein encoded by HBV, can promote oncogenesis of HCC. Nonetheless, the mechanism of HBx in hepatocarcinogenesis remains to be unclear. On this research, we set up a brand new mouse mannequin with regular immune system to analyze the position of HBx and its purposeful mechanisms below regular immune operate.
The animal mannequin was established by injecting HBx-EGFP-<em>14</em>-19 cells into the hepatic portal vein of KM mice. To confirm the mouse mannequin, the expression of HBx within the liver tissue of mice was detected by qRT-PCR, western blotting and immunohistochemistry. The apoptosis index was calculated utilizing the terminal deoxynucleotidyl transferase-dUTP nick-end labeling (TUNEL) assay, and the expression ranges of apoptosis-related and cell cycle-related elements had been measured.

Metformin alleviates hyperglycemia-induced endothelial impairment by downregulating autophagy by way of the Hedgehog pathway.

Research relating to macroautophagic/autophagic regulation in endothelial cells (ECs) below diabetic circumstances are very restricted. Medical proof establishes an endothelial protecting impact of metformin, however the underlying mechanisms stay unclear. We aimed to analyze whether or not metformin exerts its protecting position in opposition to hyperglycemia-induced endothelial impairment via the autophagy equipment. db/db mice had been handled with intravitreal metformin injections. Human umbilical vein endothelial cells (HUVECs) had been cultured both in regular glucose (NG, 5.5 mM) or excessive glucose (HG, 33 mM) medium within the presence or absence of metformin for 72 h. We noticed an apparent inhibition of hyperglycemia-triggered autophagosome synthesis in each the diabetic retinal vasculature and cultured HUVECs by metformin, together with restoration of hyperglycemia-impaired Hedgehog (Hh) pathway exercise.
Particularly, deletion of ATG7 in retinal vascular ECs of db/db mice and cultured HUVECs indicated a detrimental position of autophagy in hyperglycemia-induced endothelial dysfunction. Pretreatment with GANT61, a Hh pathway inhibitor, abolished the metformin-mediated downregulation of autophagy and endothelial protecting motion. Moreover, GLI-family (transcription elements of the Hh pathway) knockdown in HUVECs and retinal vasculature revealed that downregulation of hyperglycemia-activated autophagy by the metformin-mediated Hh pathway activation was GLI1 dependent. Mechanistically, GLI1 knockdown-triggered autophagy was associated to upregulation of BNIP3, which subsequently disrupted the affiliation of BECN1/Beclin 1 and BCL2.

Caspase 12 (Caspase 12) Antibody

abx432451-200ul 200 ul
EUR 384

Caspase 12 (Caspase 12) Antibody

abx231286-100ug 100 ug
EUR 481

Anti-Caspase-12/CASP12 Antibody

PA2103 100ug/vial
EUR 334

Caspase-12 Antibody

24119-100ul 100ul
EUR 390

Caspase-12 Antibody

24120-100ul 100ul
EUR 390

Caspase-12 Antibody

2325-002mg 0.02 mg
EUR 171.82
Description: Caspase-12 Antibody: Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.

Caspase-12 Antibody

2325-01mg 0.1 mg
EUR 436.42
Description: Caspase-12 Antibody: Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.

Caspase-12 Antibody

2327-002mg 0.02 mg
EUR 171.82
Description: Caspase-12 Antibody: Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta.

Caspase-12 Antibody

2327-01mg 0.1 mg
EUR 436.42
Description: Caspase-12 Antibody: Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta.

Caspase 12 antibody

20R-1513 100 ug
EUR 673
Description: Rabbit polyclonal Caspase 12 antibody

Caspase 12 antibody

70R-11740 100 ug
EUR 460
Description: Rabbit polyclonal Caspase 12 antibody

Caspase 12 antibody

70R-51166 100 ul
EUR 244
Description: Purified Polyclonal Caspase 12 antibody

Caspase-12 Antibody

3282-100
EUR 354

Caspase-12 Antibody

3282-30T
EUR 146

Anti-Caspase 12 (aa232-244) antibody

STJ72856 100 µg
EUR 359

Human cysteinyl aspartate specific proteinases 12,Caspase-12 ELISA Kit

201-12-0763 96 tests
EUR 440
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Caspase-12

RA15048 100 ug
EUR 461

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 349

Polyclonal Caspase-12 Antibody

APR00058G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 . This antibody is tested and proven to work in the following applications:

Polyclonal Caspase-12 Antibody

APR06275G 0.1 mg
EUR 659
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 . This antibody is tested and proven to work in the following applications:

Polyclonal Caspase-12 Antibody

APR06276G 0.1 mg
EUR 659
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 . This antibody is tested and proven to work in the following applications:

Caspase-12 Antibody (Large)

24208-100ul 100ul
EUR 390

Caspase-12 Antibody (Small)

24209-100ul 100ul
EUR 390

Caspase 12 Polyclonal Antibody

ABP50853-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of Caspase 12 from Human. This Caspase 12 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Caspase12

Caspase 12 Polyclonal Antibody

ABP50853-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of Caspase 12 from Human. This Caspase 12 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Caspase12

Caspase 12 Polyclonal Antibody

ABP50853-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of Caspase 12 from Human. This Caspase 12 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Caspase12

Caspase 12 (CASP12) Antibody

20-abx129818
  • EUR 411.00
  • EUR 133.00
  • EUR 1135.00
  • EUR 551.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Caspase 12 (CASP12) Antibody

20-abx111421
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul

Caspase 12 (CASP12) Antibody

20-abx318255
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Caspase 12 (Casp12) Antibody

20-abx318989
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Caspase 12 (CASP12) Antibody

20-abx100899
  • EUR 425.00
  • EUR 133.00
  • EUR 1177.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Caspase 12 (CASP12) Antibody

abx026563-400ul 400 ul
EUR 523

Caspase 12 (CASP12) Antibody

abx026563-80l 80 µl
EUR 286

Caspase 12 (CASP12) Antibody

20-abx213378
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul

Caspase 12 (CASP12) Antibody

20-abx210324
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul

Caspase 12 (CASP12) Antibody

abx216233-100ug 100 ug
EUR 439

Caspase 12 (CASP12) Antibody

20-abx324638
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug

Caspase-12 Antibody (Large)

3195-002mg 0.02 mg
EUR 171.82
Description: Caspase-12 Antibody: (Large)Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.

Caspase-12 Antibody (Large)

3195-01mg 0.1 mg
EUR 436.42
Description: Caspase-12 Antibody: (Large)Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.

Caspase-12 Antibody (Small)

3197-002mg 0.02 mg
EUR 171.82
Description: Caspase-12 Antibody: (Small)Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.

Caspase-12 Antibody (Small)

3197-01mg 0.1 mg
EUR 436.42
Description: Caspase-12 Antibody: (Small)Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.

Caspase-12 Peptide

2325P 0.05 mg
EUR 164.75
Description: (NT) Caspase-12 peptide

Caspase-12 Peptide

2327P 0.05 mg
EUR 164.75
Description: (IN) Caspase-12 peptide

Rabbit Anti Caspase-12 (Aa100-116) Polyclonal Antibody

CPBT-66303RC 0.1 mg
EUR 580

Polyclonal Caspase-12 Antibody (Large)

APR06327G 0.1 mg
EUR 659
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 (Large). This antibody is tested and proven to work in the following applications:

Polyclonal Caspase-12 Antibody (Small)

APR06328G 0.1 mg
EUR 659
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 (Small). This antibody is tested and proven to work in the following applications:

Caspase 12 (Casp12) Antibody (HRP)

20-abx318990
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Caspase 12 (Casp12) Antibody (FITC)

20-abx318991
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Caspase 12 (Casp12) Antibody (Biotin)

20-abx318992
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Caspase 12 (CASP12) Antibody (HRP)

20-abx316303
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Caspase 12 (CASP12) Antibody (FITC)

20-abx316304
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Caspase 12 (CASP12) Antibody (Biotin)

20-abx316305
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Recombinant Caspase 12 (CASP12)

4-RPA682Mu01
  • EUR 467.36
  • EUR 228.00
  • EUR 1477.60
  • EUR 559.20
  • EUR 1018.40
  • EUR 376.00
  • EUR 3544.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Caspase 12 expressed in: E.coli

Recombinant Caspase 12 (CASP12)

4-RPA682Ra01
  • EUR 494.24
  • EUR 235.00
  • EUR 1578.40
  • EUR 592.80
  • EUR 1085.60
  • EUR 394.00
  • EUR 3796.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Caspase 12 expressed in: E.coli

Caspase 12 Blocking Peptide

20-abx064041
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg

Caspase-12 Rabbit pAb

A0217-100ul 100 ul
EUR 308

Caspase-12 Rabbit pAb

A0217-200ul 200 ul
EUR 459

Caspase-12 Rabbit pAb

A0217-20ul 20 ul
EUR 183

Caspase-12 Rabbit pAb

A0217-50ul 50 ul
EUR 223

Caspase 12 Assay Kit

55R-1290 25 assays
EUR 328
Description: Assay Kit for detection of Capase 12 activity in the research laboratory

Caspase-12 Peptide (Large)

3195P 0.05 mg
EUR 164.75
Description: Caspase-12 peptide (Large)

Caspase-12 Peptide (Small)

3197P 0.05 mg
EUR 164.75
Description: Caspase-12 peptide (Small)

Caspase 12 Blocking Peptide

33R-10465 50 ug
EUR 349
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Caspase 12 antibody, catalog no. 20R-1513

Caspase 12 Blocking Peptide

33R-10701 50 ug
EUR 191
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Caspase 12 antibody, catalog no. 70R-11740

Caspase-12 Blocking Peptide

3282BP-50
EUR 153

99445-12 DCT 12 X 75MM

99445-12 250/pk
EUR 67
Description: Disposable Culture Tubes; DCT's, CGW

Human Caspase 12,Casp-12 ELISA Kit

CN-03708H1 96T
EUR 486

Human Caspase 12,Casp-12 ELISA Kit

CN-03708H2 48T
EUR 336

Caspase 12 (CASP12) Polyclonal Antibody (Mouse)

4-PAA682Mu01
  • EUR 236.00
  • EUR 2338.00
  • EUR 586.00
  • EUR 294.00
  • EUR 209.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12)

Anserini Caspase-12 ELISA Kit

EAC0697 96Tests
EUR 521

Rat Caspase-12 ELISA Kit

ERC0697 96Tests
EUR 521

Rabbit Caspase-12 ELISA Kit

ERTC0697 96Tests
EUR 521

Mouse Caspase-12 ELISA Kit

EMC0697 96Tests
EUR 521

Porcine Caspase-12 ELISA Kit

EPC0697 96Tests
EUR 521

Human Caspase-12 ELISA Kit

EHC0697 96Tests
EUR 521

Canine Caspase-12 ELISA Kit

ECC0697 96Tests
EUR 521

Goat Caspase-12 ELISA Kit

EGTC0697 96Tests
EUR 521

Bovine Caspase-12 ELISA Kit

EBC0697 96Tests
EUR 521

Rat Caspase 12 (CASP12) Protein

20-abx065753
  • EUR 690.00
  • EUR 286.00
  • EUR 2124.00
  • EUR 815.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Caspase 12 (CASP12) Protein

20-abx167225
  • EUR 648.00
  • EUR 272.00
  • EUR 1998.00
  • EUR 773.00
  • EUR 467.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Caspase-12 Fluorometric Assay Kit

K2150-100 100 assays
EUR 529

Caspase-12 Fluorometric Assay Kit

K2150-25 25 assays
EUR 251

Caspase 12 ELISA KIT|Human

EF008399 96 Tests
EUR 689

Rat Caspase 12 ELISA kit

E02C0690-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Rat Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Caspase 12 ELISA kit

E02C0690-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Rat Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Caspase 12 ELISA kit

E02C0690-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Rat Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Caspase 12 ELISA kit

E09C0690-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Monkey Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Caspase 12 ELISA kit

E09C0690-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Monkey Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Caspase 12 ELISA kit

E09C0690-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Monkey Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Caspase 12 ELISA kit

E03C0690-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Mouse Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Caspase 12 ELISA kit

E03C0690-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Mouse Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Caspase 12 ELISA kit

E03C0690-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Mouse Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Caspase 12 ELISA kit

E01C0690-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Human Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Caspase 12 ELISA kit

E01C0690-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Human Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Caspase 12 ELISA kit

E01C0690-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Human Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Caspase 12 ELISA kit

E07C0690-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Porcine Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Caspase 12 ELISA kit

E07C0690-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Porcine Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Caspase 12 ELISA kit

E07C0690-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Porcine Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Caspase 12 ELISA kit

E06C0690-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Goat Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Caspase 12 ELISA kit

E06C0690-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Goat Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Caspase 12 ELISA kit

E06C0690-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Goat Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Caspase-12 Fluorometric Assay Kit

K139-100
EUR 501

Caspase-12 Fluorometric Assay Kit

K139-25
EUR 256

Caspase-12 Substrate ATAD-AFC

1117-1000
EUR 1088

Caspase-12 Substrate ATAD-AFC

1117-200
EUR 436

Rabbit Caspase 12 ELISA kit

E04C0690-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Rabbit Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Caspase 12 ELISA kit

E04C0690-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Rabbit Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Caspase 12 ELISA kit

E04C0690-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Rabbit Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Caspase 12 ELISA kit

E08C0690-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Canine Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Caspase 12 ELISA kit

E08C0690-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Canine Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Caspase 12 ELISA kit

E08C0690-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Canine Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse), APC

4-PAA682Mu01-APC
  • EUR 329.00
  • EUR 3041.00
  • EUR 854.00
  • EUR 416.00
  • EUR 212.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with APC.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse), Biotinylated

4-PAA682Mu01-Biotin
  • EUR 299.00
  • EUR 2288.00
  • EUR 684.00
  • EUR 363.00
  • EUR 214.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with Biotin.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse), Cy3

4-PAA682Mu01-Cy3
  • EUR 397.00
  • EUR 4013.00
  • EUR 1097.00
  • EUR 513.00
  • EUR 241.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with Cy3.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse), FITC

4-PAA682Mu01-FITC
  • EUR 283.00
  • EUR 2452.00
  • EUR 703.00
  • EUR 353.00
  • EUR 189.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with FITC.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse), HRP

4-PAA682Mu01-HRP
  • EUR 302.00
  • EUR 2652.00
  • EUR 756.00
  • EUR 377.00
  • EUR 200.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with HRP.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse), PE

4-PAA682Mu01-PE
  • EUR 283.00
  • EUR 2452.00
  • EUR 703.00
  • EUR 353.00
  • EUR 189.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with PE.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse, Rat)

4-PAA682Ra01
  • EUR 243.00
  • EUR 2457.00
  • EUR 613.00
  • EUR 305.00
  • EUR 212.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse, Rat Caspase 12 (CASP12)

Individual Reaction Mix 12

G065-12 200 reactions
EUR 167

Human 12-lipoxygenase,LOX-12 ELISA Kit

201-12-0949 96 tests
EUR 440
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Anti-Caspase-3 antibody

STJ119192 100 µl
EUR 277
Description: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.

Anti-Caspase-3 antibody

STJ119193 100 µl
EUR 277
Description: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.

Anti-Caspase-3 antibody

STJ119900 100 µl
EUR 393

Anti-caspase-1 antibody

STJ16101311 100 µg
EUR 716

Anti-caspase-4 antibody

STJ16101312 100 µg
EUR 689

Anti-caspase-7 antibody

STJ16101313 100 µg
EUR 689

Anti-caspase-1 antibody

STJ16101447 100 µg
EUR 716

Anti-caspase-4 antibody

STJ16101448 100 µg
EUR 689

Anti-caspase-7 antibody

STJ16101449 100 µg
EUR 689

Anti-Caspase-4 antibody

STJ11100597 100 µl
EUR 277

Anti-Caspase-9 antibody

STJ11100939 100 µl
EUR 393
Description: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.

Anti-Caspase-1 Antibody

A00048 100ug
EUR 432
Description: Rabbit Polyclonal Caspase-1 Antibody. Validated in IP, IF, IHC, WB and tested in Human, Mouse, Rat.

Anti-Caspase-4 Antibody

A02941 100ul
EUR 397
Description: Rabbit Polyclonal Caspase-4 Antibody. Validated in IHC, WB and tested in Human, Mouse, Rat.

Anti-Caspase-10 antibody

STJ96459 200 µl
EUR 197
Description: Rabbit polyclonal to Caspase-10.

Anti-Caspase-3 antibody

STJ96569 200 µl
EUR 197
Description: Caspase-3 is a protein encoded by the CASP3 gene which is approximately 31,6 kDa. Caspase-3 is localised to the cytoplasm. It is involved in the TNFR1 pathway, apoptosis modulation and signalling and respiratory electron transport. This protein falls under the cysteine-aspartic acid protease family. It is a sequential activatior of caspases and plays a central role in the execution-phase of cell apoptosis. Caspase-3 is highly expressed in lung, spleen, heart, liver and kidney. Mutations in the CASP3 gene may result in bladder urothelial carcinoma and primary effusion lymphoma. STJ96569 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of fragment of Caspase-3 protein.

Anti-Caspase 9 antibody

STJ96979 200 µl
EUR 197
Description: Caspase-9 is a protein encoded by the CASP9 gene which is approximately 46,2 kDa. Caspase-9 is localised to the cytosol, mitochondrion and nucleus. It is involved in the TNFR1 pathway, RET signalling and apoptosis modulation and signalling. Caspase-9 exist as an inactive proenzyme which undergoes proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. It is involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Caspase-9 is ubiquitously expressed with highest expression in the heart. Mutations in the CASP9 gene may result in cerebral hypoxia and cervical cancer. STJ96979 was affinity purified. This monoclonal antibody binds endogenous caspase-9.

Anti-Caspase-8 antibody

STJ97394 200 µl
EUR 197
Description: Caspase-8 is a protein encoded by the CASP8 gene which is approximately 55,3 kDa. Caspase-8 is localised to the cytoplasm and is involved in the TNFR1 pathway, dimerization of procaspase-8, activated TLR4 signalling, apoptosis signalling and toll-like receptor signalling pathways. This protein falls under the cysteine-aspartic acid protease family. It pays a role in the programmed cell death induced by Fas and various apoptotic stimuli. Caspase-8 isoform 1, 5 and 7 are expressed in a wide variety of tissues. Mutations in the CASP8 gene may result in a caspase-8 deficiency. STJ97394 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Caspase-8 protein.

Anti-Caspase-3 antibody

STJ97452 200 µl
EUR 197
Description: Rabbit polyclonal to Caspase-3.

Anti-Caspase-8 antibody

STJ97456 200 µl
EUR 197
Description: Rabbit polyclonal to Caspase-8.

Anti-Caspase-3 antibody

STJ97723 200 µl
EUR 197
Description: Mouse monoclonal to Caspase-3.

Anti-Caspase-3 antibody

STJ97730 200 µl
EUR 197
Description: Mouse monoclonal to Caspase-3.

Anti-Caspase-8 antibody

STJ97895 100 µl
EUR 234
Description: Mouse monoclonal to Caspase-8.

Anti-Caspase-1 antibody

STJ98574 200 µl
EUR 197
Description: Caspase-1 is a protein encoded by the CASP1 gene which is approximately 45,1 kDa. Caspase-1 is localised to the cytoplasm. It is involved in amyotrophic lateral sclerosis, toll-like receptor signalling pathways, p53 signalling and the TNFR1 pathway. This protein falls under the the cysteine-aspartic acid protease family. upon activation It plays a central role in the execution-phase of cell apoptosis. These enzymes can be divided into initiators and effectors. The initiator isoforms are activated by, and interact with, upstream adaptor molecules. Caspase-1 is expressed mainly in the spleen and lung. Mutations in the CASP1 gene may result in shigellosis and cowpox. STJ98574 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Caspase-1.

Anti-Caspase-3 antibody

STJ92021 200 µl
EUR 197
Description: Rabbit polyclonal to Caspase-3.
The position of BNIP3 in BECN1 dissociation from BCL2 was additional confirmed by BNIP3 overexpression or BNIP3 RNAi. Taken collectively, the endothelial protecting impact of metformin below hyperglycemia circumstances could possibly be partly attributed to its position in downregulating autophagy by way of Hh pathway activation. Abbreviations: 3-MA = 3-methyladenine; 8×GLI BS-FL = 8×GLI-binding website firefly luciferase; AAV = adeno-associated virus; AAV-Cdh5-sh-Atg7 = AAV vectors carrying shRNA in opposition to murine Atg7 below management of murine Cdh5 promoter.