Background Transforming biomarkers carry excessive potential for predicting hostile occasions in persistent coronary heart failure ( CHF ) sufferers. Nonetheless, temporal patterns throughout the course of CHF , and particularly the trajectory earlier than an hostile occasion, are unknown. We studied the prognostic worth of temporal patterns of cardiac reworking biomarker candidates in steady sufferers with CHF from the Bio-SHiFT (Serial Biomarker Measurements and New Echocardiographic Methods in Persistent Coronary heart Failure Sufferers End in Tailor-made Prediction of Prognosis) research. Strategies and Outcomes In 263 CHF sufferers, we carried out trimonthly blood sampling throughout a median follow-up of two.2 years.
For the evaluation, we chosen all baseline samples, the two samples closest to the first finish level ( PE ), or the final pattern out there for finish point-free sufferers. Thus, in 567 samples, we measured suppression of tumorigenicity-2, galectin-3, galectin-4, progress differentiation factor-15, matrix metalloproteinase-2, 3, and 9, tissue inhibitor metalloproteinase-4, perlecan, aminopeptidase-N, <em>caspase</em>-3, cathepsin-D, cathepsin-Z, and cystatin-B. The PE was a composite of cardiovascular mortality, coronary heart transplantation, left ventricular help machine implantation, and HF hospitalization. Associations between repeatedly measured biomarker candidates and the PE had been investigated by joint modeling. Median age was 68 (interquartile vary: 59-76) years with 72% males; 70 sufferers reached the PE . Repeatedly measured suppression of tumorigenicity-2, galectin-3, galectin-4, progress differentiation factor-15, matrix metalloproteinase-2 and 9, tissue inhibitor metalloproteinase-4, perlecan, cathepsin-D, and cystatin-B ranges had been considerably related to the PE , and elevated because the PE approached. The slopes of biomarker trajectories had been additionally predictors of scientific end result, impartial of their absolute stage. Associations continued after adjustment for scientific traits and pharmacological therapy.
Suppression of tumorigenicity-2 was the strongest predictor (hazard ratio: 7.55 per SD distinction, 95% CI : 5.53-10.30), adopted by progress differentiation factor-15 and matrix metalloproteinase-2. Conclusions Temporal patterns of reworking biomarker candidates predict hostile scientific outcomes in CHF. JNK and its downstream transcriptional elements together with c-Jun, activating transcription issue 2 (ATF2), and JunD had been all considerably phosphorylated in CIH rats. Nonetheless, pretreatment of NF-κB inhibitor BAY 11-7082 inhibited the activation of NF-κB below CIH situation and likewise considerably decreased the phosphorylation of JNK in addition to c-Jun, ATF2, and JunD.
Novel compound VB-037 inhibits Aβ aggregation and promotes neurite outgrowth via enhancement of HSP27 and discount of P38 and JNK-mediated irritation in cell fashions for Alzheimer’s illness.
The pathogenesis of Alzheimer’s illness (AD) is concerned within the aggregation of misfolded amyloid β (Aβ), which upregulates the exercise of acetylcholinesterase (AChE), will increase the manufacturing of reactive oxygen species (ROS), enhances neuroinflammation, and finally results in neuronal dying. Due to this fact, compounds concentrating on these mechanisms could also be candidates for multitarget medication in AD therapy. We discovered that two quinoline derivatives, VB-030 and VB-037, markedly decreased Aβ aggregation and ROS ranges within the thioflavin T biochemical assay and Tet-On Aβ-green fluorescent protein (GFP) 293 AD cell mannequin. These compounds additional improved neurite outgrowth, decreased AChE exercise and upregulated the molecular chaperone warmth shock protein household B [small] member 1 (HSP27), whereas knockdown of HSP27 counteracted the compounds’ neuroprotective results on the Tet-On neuronal mannequin. Moreover, VB-037 attenuated lipopolysaccharide (LPS)/interferon (IFN)-γ-induced activation of BV-2 microglial cells.
As well as, VB-037 demonstrated its potential to decrease LPS/IFN-γ-induced upregulation of <em>caspase</em> 1 exercise, expression of interleukin (IL)-1β, and lively phosphorylation of mitogen-activated protein kinase <em>14</em> (P38), mitogen-activated protein kinase 8 (JNK), and Jun proto-oncogene, AP-1 transcription issue subunit (JUN) signalings, in addition to enhance cell viability within the Tet-On neuronal mannequin. Our findings strongly point out the potential of VB-037 for modifying AD development by concentrating on a number of mechanisms, thereby providing a brand new drug improvement avenue for AD therapy. Hepatitis B virus X (HBx), a viral onco-protein encoded by HBV, can promote oncogenesis of HCC. Nonetheless, the mechanism of HBx in hepatocarcinogenesis remains to be unclear. On this research, we set up a brand new mouse mannequin with regular immune system to analyze the position of HBx and its purposeful mechanisms below regular immune operate.
The animal mannequin was established by injecting HBx-EGFP-<em>14</em>-19 cells into the hepatic portal vein of KM mice. To confirm the mouse mannequin, the expression of HBx within the liver tissue of mice was detected by qRT-PCR, western blotting and immunohistochemistry. The apoptosis index was calculated utilizing the terminal deoxynucleotidyl transferase-dUTP nick-end labeling (TUNEL) assay, and the expression ranges of apoptosis-related and cell cycle-related elements had been measured.
Metformin alleviates hyperglycemia-induced endothelial impairment by downregulating autophagy by way of the Hedgehog pathway.
Research relating to macroautophagic/autophagic regulation in endothelial cells (ECs) below diabetic circumstances are very restricted. Medical proof establishes an endothelial protecting impact of metformin, however the underlying mechanisms stay unclear. We aimed to analyze whether or not metformin exerts its protecting position in opposition to hyperglycemia-induced endothelial impairment via the autophagy equipment. db/db mice had been handled with intravitreal metformin injections. Human umbilical vein endothelial cells (HUVECs) had been cultured both in regular glucose (NG, 5.5 mM) or excessive glucose (HG, 33 mM) medium within the presence or absence of metformin for 72 h. We noticed an apparent inhibition of hyperglycemia-triggered autophagosome synthesis in each the diabetic retinal vasculature and cultured HUVECs by metformin, together with restoration of hyperglycemia-impaired Hedgehog (Hh) pathway exercise.
Particularly, deletion of ATG7 in retinal vascular ECs of db/db mice and cultured HUVECs indicated a detrimental position of autophagy in hyperglycemia-induced endothelial dysfunction. Pretreatment with GANT61, a Hh pathway inhibitor, abolished the metformin-mediated downregulation of autophagy and endothelial protecting motion. Moreover, GLI-family (transcription elements of the Hh pathway) knockdown in HUVECs and retinal vasculature revealed that downregulation of hyperglycemia-activated autophagy by the metformin-mediated Hh pathway activation was GLI1 dependent. Mechanistically, GLI1 knockdown-triggered autophagy was associated to upregulation of BNIP3, which subsequently disrupted the affiliation of BECN1/Beclin 1 and BCL2.
Anti-Caspase-12 Antibody |
A04700 |
BosterBio |
100ug |
EUR 565.2 |
Description: Rabbit Polyclonal Caspase-12 Antibody. Validated in IHC, WB and tested in Human, Mouse, Rat. |
Anti-Caspase-12/CASP12 Antibody |
PA2103 |
BosterBio |
100ug/vial |
EUR 400.8 |
Caspase 12 antibody |
70R-51166 |
Fitzgerald |
100 ul |
EUR 292.8 |
Description: Purified Polyclonal Caspase 12 antibody |
Caspase 12 antibody |
70R-11740 |
Fitzgerald |
100 ug |
EUR 552 |
Description: Rabbit polyclonal Caspase 12 antibody |
Caspase-12 Antibody |
2325-002mg |
ProSci |
0.02 mg |
EUR 206.18 |
|
Description: Caspase-12 Antibody: Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues. |
Caspase-12 Antibody |
2325-01mg |
ProSci |
0.1 mg |
EUR 523.7 |
|
Description: Caspase-12 Antibody: Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues. |
Caspase-12 Antibody |
2327-002mg |
ProSci |
0.02 mg |
EUR 206.18 |
|
Description: Caspase-12 Antibody: Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. |
Caspase-12 Antibody |
2327-01mg |
ProSci |
0.1 mg |
EUR 523.7 |
|
Description: Caspase-12 Antibody: Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. |
Caspase-12 Antibody |
24119-100ul |
SAB |
100ul |
EUR 468 |
Caspase-12 Antibody |
24120-100ul |
SAB |
100ul |
EUR 468 |
Caspase 12 antibody |
20R-1513 |
Fitzgerald |
100 ug |
EUR 807.6 |
Description: Rabbit polyclonal Caspase 12 antibody |
Caspase-12 Antibody |
3282-100 |
Biovision |
each |
EUR 424.8 |
Caspase-12 Antibody |
3282-30T |
Biovision |
each |
EUR 175.2 |
Human cysteinyl aspartate specific proteinases 12,Caspase-12 ELISA Kit |
201-12-0763 |
SunredBio |
96 tests |
EUR 528 |
|
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
Caspase-12 |
RA15048 |
Neuromics |
100 ug |
EUR 553.2 |
Rabbit Polyclonal antibody Anti-CRBN |
Anti-CRBN |
ImmunoStep |
50 µg |
EUR 418.8 |
Caspase 12 Polyclonal Antibody |
ABP50853-003ml |
Abbkine |
0.03ml |
EUR 189.6 |
|
Description: A polyclonal antibody for detection of Caspase 12 from Human. This Caspase 12 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Caspase12 |
Caspase 12 Polyclonal Antibody |
ABP50853-01ml |
Abbkine |
0.1ml |
EUR 346.8 |
|
Description: A polyclonal antibody for detection of Caspase 12 from Human. This Caspase 12 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Caspase12 |
Caspase 12 Polyclonal Antibody |
ABP50853-02ml |
Abbkine |
0.2ml |
EUR 496.8 |
|
Description: A polyclonal antibody for detection of Caspase 12 from Human. This Caspase 12 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Caspase12 |
Caspase-12 Antibody (Large) |
24208-100ul |
SAB |
100ul |
EUR 468 |
Caspase-12 Antibody (Small) |
24209-100ul |
SAB |
100ul |
EUR 468 |
Caspase-12 Antibody (Large) |
3195-002mg |
ProSci |
0.02 mg |
EUR 206.18 |
|
Description: Caspase-12 Antibody: (Large)Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues. |
Caspase-12 Antibody (Large) |
3195-01mg |
ProSci |
0.1 mg |
EUR 523.7 |
|
Description: Caspase-12 Antibody: (Large)Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues. |
Caspase-12 Antibody (Small) |
3197-002mg |
ProSci |
0.02 mg |
EUR 206.18 |
|
Description: Caspase-12 Antibody: (Small)Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues. |
Caspase-12 Antibody (Small) |
3197-01mg |
ProSci |
0.1 mg |
EUR 523.7 |
|
Description: Caspase-12 Antibody: (Small)Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues. |
Caspase 12 (CASP12) Antibody |
20-abx100899 |
Abbexa |
-
EUR 510.00
-
EUR 159.60
-
EUR 1412.40
-
EUR 693.60
-
EUR 393.60
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
Caspase 12 (CASP12) Antibody |
20-abx111421 |
Abbexa |
|
|
|
Caspase 12 (CASP12) Antibody |
20-abx129818 |
Abbexa |
-
EUR 493.20
-
EUR 159.60
-
EUR 1362.00
-
EUR 661.20
-
EUR 376.80
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
Caspase 12 (CASP12) Antibody |
abx026563-400ul |
Abbexa |
400 ul |
EUR 627.6 |
|
Caspase 12 (CASP12) Antibody |
abx026563-80l |
Abbexa |
80 µl |
EUR 343.2 |
|
Caspase 12 (CASP12) Antibody |
20-abx210324 |
Abbexa |
|
|
|
Caspase 12 (CASP12) Antibody |
20-abx324638 |
Abbexa |
|
|
|
Caspase 12 (CASP12) Antibody |
20-abx318255 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
Caspase 12 (Casp12) Antibody |
20-abx318989 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
Caspase 12 (CASP12) Antibody |
abx216233-100ug |
Abbexa |
100 ug |
EUR 526.8 |
|
Caspase 12 (CASP12) Antibody |
20-abx213378 |
Abbexa |
|
|
|
Polyclonal Caspase-12 Antibody |
APR06275G |
Leading Biology |
0.1 mg |
EUR 790.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 . This antibody is tested and proven to work in the following applications: |
Polyclonal Caspase-12 Antibody |
APR06276G |
Leading Biology |
0.1 mg |
EUR 790.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 . This antibody is tested and proven to work in the following applications: |
Polyclonal Caspase-12 Antibody |
APR00058G |
Leading Biology |
0.1mg |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 . This antibody is tested and proven to work in the following applications: |
Caspase-12 Peptide |
2325P |
ProSci |
0.05 mg |
EUR 197.7 |
Description: (NT) Caspase-12 peptide |
Caspase-12 Peptide |
2327P |
ProSci |
0.05 mg |
EUR 197.7 |
Description: (IN) Caspase-12 peptide |
Caspase 12 (Casp12) Antibody (HRP) |
20-abx318990 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
Caspase 12 (Casp12) Antibody (FITC) |
20-abx318991 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
Caspase 12 (Casp12) Antibody (Biotin) |
20-abx318992 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
Caspase 12 (CASP12) Antibody (HRP) |
20-abx316303 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
Caspase 12 (CASP12) Antibody (FITC) |
20-abx316304 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
Caspase 12 (CASP12) Antibody (Biotin) |
20-abx316305 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
Polyclonal Caspase-12 Antibody (Large) |
APR06327G |
Leading Biology |
0.1 mg |
EUR 790.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 (Large). This antibody is tested and proven to work in the following applications: |
Polyclonal Caspase-12 Antibody (Small) |
APR06328G |
Leading Biology |
0.1 mg |
EUR 790.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 (Small). This antibody is tested and proven to work in the following applications: |
Rabbit Anti Caspase-12 (Aa100-116) Polyclonal Antibody |
CPBT-66303RC |
Creative Diagnostics |
0.1 mg |
EUR 696 |
Caspase 12 Assay Kit |
55R-1290 |
Fitzgerald |
25 assays |
EUR 393.6 |
Description: Assay Kit for detection of Capase 12 activity in the research laboratory |
Caspase 12 Blocking Peptide |
33R-10465 |
Fitzgerald |
50 ug |
EUR 418.8 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Caspase 12 antibody, catalog no. 20R-1513 |
Caspase 12 Blocking Peptide |
33R-10701 |
Fitzgerald |
50 ug |
EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Caspase 12 antibody, catalog no. 70R-11740 |
Caspase-12 Peptide (Large) |
3195P |
ProSci |
0.05 mg |
EUR 197.7 |
Description: Caspase-12 peptide (Large) |
Caspase-12 Peptide (Small) |
3197P |
ProSci |
0.05 mg |
EUR 197.7 |
Description: Caspase-12 peptide (Small) |
Caspase 12 Blocking Peptide |
20-abx064041 |
Abbexa |
|
|
|
Caspase-12 Rabbit pAb |
A0217-100ul |
Abclonal |
100 ul |
EUR 369.6 |
Caspase-12 Rabbit pAb |
A0217-200ul |
Abclonal |
200 ul |
EUR 550.8 |
Caspase-12 Rabbit pAb |
A0217-20ul |
Abclonal |
20 ul |
EUR 219.6 |
Caspase-12 Rabbit pAb |
A0217-50ul |
Abclonal |
50 ul |
EUR 267.6 |
Recombinant Caspase 12 (CASP12) |
4-RPA682Mu01 |
Cloud-Clone |
-
EUR 560.83
-
EUR 273.60
-
EUR 1773.12
-
EUR 671.04
-
EUR 1222.08
-
EUR 451.20
-
EUR 4252.80
|
- 100 ug
- 10ug
- 1 mg
- 200 ug
- 500 ug
- 50ug
- 5 mg
|
|
Description: Recombinant Mouse Caspase 12 expressed in: E.coli |
Recombinant Caspase 12 (CASP12) |
4-RPA682Ra01 |
Cloud-Clone |
-
EUR 593.09
-
EUR 282.00
-
EUR 1894.08
-
EUR 711.36
-
EUR 1302.72
-
EUR 472.80
-
EUR 4555.20
|
- 100 ug
- 10ug
- 1 mg
- 200 ug
- 500 ug
- 50ug
- 5 mg
|
|
Description: Recombinant Rat Caspase 12 expressed in: E.coli |
Caspase-12 Blocking Peptide |
3282BP-50 |
Biovision |
each |
EUR 183.6 |
99445-12 DCT 12 X 75MM |
99445-12 |
CORNING |
250/pk |
EUR 80.4 |
Description: Disposable Culture Tubes; DCT's, CGW |
Human Caspase 12,Casp-12 ELISA Kit |
CN-03708H1 |
ChemNorm |
96T |
EUR 583.2 |
Human Caspase 12,Casp-12 ELISA Kit |
CN-03708H2 |
ChemNorm |
48T |
EUR 403.2 |
Caspase 12 (CASP12) Polyclonal Antibody (Mouse) |
4-PAA682Mu01 |
Cloud-Clone |
-
EUR 283.20
-
EUR 2805.60
-
EUR 703.20
-
EUR 352.80
-
EUR 250.80
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12) |
Human Caspase 12 ELISA kit |
E01C0690-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Human Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Caspase 12 ELISA kit |
E01C0690-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Human Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Caspase 12 ELISA kit |
E01C0690-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Human Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Caspase 12 ELISA kit |
E02C0690-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Rat Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Caspase 12 ELISA kit |
E02C0690-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Rat Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Caspase 12 ELISA kit |
E02C0690-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Rat Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig Caspase 12 ELISA kit |
E07C0690-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Porcine Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig Caspase 12 ELISA kit |
E07C0690-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Porcine Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig Caspase 12 ELISA kit |
E07C0690-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Porcine Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat Caspase 12 ELISA kit |
E06C0690-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Goat Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat Caspase 12 ELISA kit |
E06C0690-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Goat Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat Caspase 12 ELISA kit |
E06C0690-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Goat Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit Caspase 12 ELISA kit |
E04C0690-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Rabbit Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit Caspase 12 ELISA kit |
E04C0690-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Rabbit Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit Caspase 12 ELISA kit |
E04C0690-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Rabbit Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog Caspase 12 ELISA kit |
E08C0690-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Canine Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog Caspase 12 ELISA kit |
E08C0690-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Canine Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog Caspase 12 ELISA kit |
E08C0690-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Canine Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Caspase 12 ELISA kit |
E09C0690-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Monkey Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Caspase 12 ELISA kit |
E09C0690-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Monkey Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Caspase 12 ELISA kit |
E09C0690-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Monkey Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Caspase 12 ELISA kit |
E03C0690-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Mouse Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Caspase 12 ELISA kit |
E03C0690-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Mouse Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Caspase 12 ELISA kit |
E03C0690-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Mouse Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Caspase-12 ELISA Kit |
EMC0697 |
Abclonal |
96Tests |
EUR 625.2 |
Human Caspase-12 ELISA Kit |
EHC0697 |
Abclonal |
96Tests |
EUR 625.2 |
Rat Caspase-12 ELISA Kit |
ERC0697 |
Abclonal |
96Tests |
EUR 625.2 |
Rabbit Caspase-12 ELISA Kit |
ERTC0697 |
Abclonal |
96Tests |
EUR 625.2 |
Porcine Caspase-12 ELISA Kit |
EPC0697 |
Abclonal |
96Tests |
EUR 625.2 |
Mouse Caspase 12 (CASP12) Protein |
20-abx167225 |
Abbexa |
-
EUR 777.60
-
EUR 326.40
-
EUR 2397.60
-
EUR 927.60
-
EUR 560.40
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
Rat Caspase 12 (CASP12) Protein |
20-abx065753 |
Abbexa |
-
EUR 828.00
-
EUR 343.20
-
EUR 2548.80
-
EUR 978.00
-
EUR 594.00
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
Goat Caspase-12 ELISA Kit |
EGTC0697 |
Abclonal |
96Tests |
EUR 625.2 |
Bovine Caspase-12 ELISA Kit |
EBC0697 |
Abclonal |
96Tests |
EUR 625.2 |
Canine Caspase-12 ELISA Kit |
ECC0697 |
Abclonal |
96Tests |
EUR 625.2 |
Caspase-12 Fluorometric Assay Kit |
K2150-100 |
ApexBio |
100 assays |
EUR 634.8 |
Caspase-12 Fluorometric Assay Kit |
K2150-25 |
ApexBio |
25 assays |
EUR 301.2 |
Anserini Caspase-12 ELISA Kit |
EAC0697 |
Abclonal |
96Tests |
EUR 625.2 |
Caspase-12 Fluorometric Assay Kit |
K139-100 |
Biovision |
each |
EUR 601.2 |
Caspase-12 Fluorometric Assay Kit |
K139-25 |
Biovision |
each |
EUR 307.2 |
Caspase-12 Substrate ATAD-AFC |
1117-1000 |
Biovision |
each |
EUR 1305.6 |
Caspase-12 Substrate ATAD-AFC |
1117-200 |
Biovision |
each |
EUR 523.2 |
Caspase 12 (CASP12) Polyclonal Antibody (Mouse), APC |
4-PAA682Mu01-APC |
Cloud-Clone |
-
EUR 394.80
-
EUR 3649.20
-
EUR 1024.80
-
EUR 499.20
-
EUR 254.40
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with APC. |
Caspase 12 (CASP12) Polyclonal Antibody (Mouse), Biotinylated |
4-PAA682Mu01-Biotin |
Cloud-Clone |
-
EUR 358.80
-
EUR 2745.60
-
EUR 820.80
-
EUR 435.60
-
EUR 256.80
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with Biotin. |
Caspase 12 (CASP12) Polyclonal Antibody (Mouse), Cy3 |
4-PAA682Mu01-Cy3 |
Cloud-Clone |
-
EUR 476.40
-
EUR 4815.60
-
EUR 1316.40
-
EUR 615.60
-
EUR 289.20
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with Cy3. |
Caspase 12 (CASP12) Polyclonal Antibody (Mouse), FITC |
4-PAA682Mu01-FITC |
Cloud-Clone |
-
EUR 339.60
-
EUR 2942.40
-
EUR 843.60
-
EUR 423.60
-
EUR 226.80
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with FITC. |
Caspase 12 (CASP12) Polyclonal Antibody (Mouse), HRP |
4-PAA682Mu01-HRP |
Cloud-Clone |
-
EUR 362.40
-
EUR 3182.40
-
EUR 907.20
-
EUR 452.40
-
EUR 240.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with HRP. |
Caspase 12 (CASP12) Polyclonal Antibody (Mouse), PE |
4-PAA682Mu01-PE |
Cloud-Clone |
-
EUR 339.60
-
EUR 2942.40
-
EUR 843.60
-
EUR 423.60
-
EUR 226.80
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with PE. |
Caspase 12 (CASP12) Polyclonal Antibody (Mouse, Rat) |
4-PAA682Ra01 |
Cloud-Clone |
-
EUR 291.60
-
EUR 2948.40
-
EUR 735.60
-
EUR 366.00
-
EUR 254.40
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse, Rat Caspase 12 (CASP12) |
Individual Reaction Mix 12 |
G065-12 |
ABM |
200 reactions |
EUR 200.4 |
Human 12-lipoxygenase,LOX-12 ELISA Kit |
201-12-0949 |
SunredBio |
96 tests |
EUR 528 |
|
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
Rat Casp12/ Caspase-12 ELISA Kit |
E0156Ra |
Sunlong |
1 Kit |
EUR 685.2 |
Mouse Casp12/ Caspase-12 ELISA Kit |
E0211Mo |
Sunlong |
1 Kit |
EUR 685.2 |
Guinea pig Caspase 12 ELISA kit |
E05C0690-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Guinea pig Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Guinea pig Caspase 12 ELISA kit |
E05C0690-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Guinea pig Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Guinea pig Caspase 12 ELISA kit |
E05C0690-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Guinea pig Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Casp12(Caspase-12) ELISA Kit |
EM0436 |
FN Test |
96T |
EUR 681.12 |
|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.094 ng/ml |
ELISA kit for Mouse Caspase-12 |
EK2112 |
SAB |
96 tests |
EUR 663.6 |
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse Caspase-12 in samples from serum, plasma, tissue homogenates and other biological fluids. |
ELISA kit for Human Caspase-12 |
EK2113 |
SAB |
96 tests |
EUR 663.6 |
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Caspase-12 in samples from serum, plasma, tissue homogenates and other biological fluids. |
ELISA kit for Rat Caspase-12 |
EK2114 |
SAB |
96 tests |
EUR 663.6 |
Description: Enzyme-linked immunosorbent assay kit for quantification of Rat Caspase-12 in samples from serum, plasma, tissue homogenates and other biological fluids. |
Rat Casp12(Caspase 12) ELISA Kit |
ER0345 |
FN Test |
96T |
EUR 681.12 |
|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 0.094 ng/ml |
CaspGLOW Active Caspase 12 Staining Kit |
55R-1291 |
Fitzgerald |
25 assays |
EUR 338.4 |
Description: Caspase 12 Staining Kit for use activity in the research laboratory |
Human Caspase 12 (CASP12) CLIA Kit |
abx196504-96tests |
Abbexa |
96 tests |
EUR 990 |
|
Rat Caspase 12 (CASP12) CLIA Kit |
abx196787-96tests |
Abbexa |
96 tests |
EUR 990 |
|
Rat Caspase 12 (CASP12) ELISA Kit |
abx353550-96tests |
Abbexa |
96 tests |
EUR 943.2 |
|
Human Caspase 12 (CASP12) ELISA Kit |
20-abx259273 |
Abbexa |
-
EUR 7970.40
-
EUR 4250.40
-
EUR 990.00
|
- 10 × 96 tests
- 5 × 96 tests
- 96 tests
|
|
Human Caspase 12 (CASP12) ELISA Kit |
abx358592-96tests |
Abbexa |
96 tests |
EUR 848.4 |
|
Human Caspase 12 (CASP12) ELISA Kit |
abx513694-96tests |
Abbexa |
96 tests |
EUR 848.4 |
|
Mouse Caspase 12 (CASP12) CLIA Kit |
20-abx491877 |
Abbexa |
-
EUR 9567.60
-
EUR 5095.20
-
EUR 1177.20
|
- 10 × 96 tests
- 5 × 96 tests
- 96 tests
|
|
Rat Caspase 12 (CASP12) ELISA Kit |
abx256323-96tests |
Abbexa |
96 tests |
EUR 943.2 |
|
Mouse Caspase 12 (CASP12) ELISA Kit |
20-abx258452 |
Abbexa |
-
EUR 8853.60
-
EUR 4719.60
-
EUR 1093.20
|
- 10 × 96 tests
- 5 × 96 tests
- 96 tests
|
|
The position of BNIP3 in BECN1 dissociation from BCL2 was additional confirmed by BNIP3 overexpression or BNIP3 RNAi. Taken collectively, the endothelial protecting impact of metformin below hyperglycemia circumstances could possibly be partly attributed to its position in downregulating autophagy by way of Hh pathway activation. Abbreviations: 3-MA = 3-methyladenine; 8×GLI BS-FL = 8×GLI-binding website firefly luciferase; AAV = adeno-associated virus; AAV-Cdh5-sh-Atg7 = AAV vectors carrying shRNA in opposition to murine Atg7 below management of murine Cdh5 promoter.