caspase-14

The Effects of Melatonin on Elevated Liver Enzymes During Statins Treatment

Introduction Statins are widely used in the treatment and prevention of lipid metabolism disorders. They are generally well tolerated but not devoid of side effects. These include, among others, muscular symptoms, arthritis, headaches, gynecomastia. Myositis and rhabdomyolysis associated with increased activity of creatinine kinase and serum creatinine levels are rare but serious adverse events of statin therapy.

  • The risk of these complications is increased in elderly patients with chronic diseases and in alcohol abusers.
  • Furthermore, statins cause hepatotoxic effect which is observed in several percent of treated patients, usually in the first weeks of the therapy . Most frequently it is manifested by asymptomatic increase in the level of aspartate and alanine aminotransferase.
  • This is usually a temporary increase, but in some patients the level of these enzymes exceeds 3 times the normal limit, which is a matter of concern. In such cases, patients expect the decision to discontinue the treatment or to administer hepatoprotective drugs.
  • Acetylcholine, sylibinin, phospholipids and other drugs used for this purpose are not always effective. Therefore, there is still search for alternative drugs for the protection of liver.

In own study melatonin was used for this purpose because previous experimental studies had demonstrated that it protected liver against harmful effects of many toxic agents as well as the consequences of ischemia-reperfusion model.

The liver is an organ in which there comes to intensive metabolic and detoxification processes. In their course large amounts of reactive oxygen species are generated and they exert a toxic effect on hepatocytes.
A complex antioxidant system – in which metabolized there melatonin (pineal and from other sources) is an important part – prevents that.

The main melatonin metabolic pathway in the liver is through hydroxylation pathway at the C-6 position by 6-hydroxylase and P450 cytochromes (CYP1A1, CYP1A2, CYP2P19, CYP1B1 isozymes). The 6-hydroxymelatonin, formed in this process, is conjugated with sulphate and glucuronide to 6-hydroxymelatonin sulphate or glucuronide. In this process melatonin and its metabolites exert high antioxidant activity.

An alternative metabolic pathway includes melatonin oxidation to N-acetyl-formyl-5- methoxykynuramine (AFMK) and N-acetyl-5-methoxykynuramine (AMK). The kynurenine pathway of melatonin metabolism leads to formation of a series of free radical scavengers.

Furthermore, melatonin decreases the production of proinflammatory cytokines and inhibits hepatic fibrogenesis. Owing to its multidirectional action in liver, apoptosis and necrosis decrease, the integrity is protected and regeneration is improved.

caspase-14

caspase-14

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The aim of this study was to assess the usefulness of melatonin in counteracting the adverse hepatic events from statins.

Material and Methods Patients and Data Collection The research program included 30 subjects, aged 47-68 years, 41 women and 23 men. All women were I the postpostmenopausal period. Recruitment and diagnostic tests were conducted in the Department of Gastroenterology, Medical University of Lodz and Outpatient Consulting Clinic “Gastro” in Lodz.

The research study was performed in the years 2012-2016. Therapeutic Procedures After inclusion into the study, all patients were recommended the same balanced diet with limited animal fats and simple carbohydrates of caloric content of 1600 kcal. At the same time, they were recommended to continue the treatment with the same statin at a daily dose of 20 mg.

The patients were randomly allocated into two groups. Group I (n=30) was recommended to take statin together with melatonin (LEK-AM, Poland) at a dose of 2×5 mg, at 7:00 a.m. and 9:00 p.m. In Group II (n=30) patients took statin with placebo (LEK-AM, Poland) at the same dose and time of the day.

Follow-up laboratory tests (AST, ALT, GGT, ALP, cholesterol and triglycerides) were evaluated after 2,4 and 6 months of treatment.

Ethical procedures A written consent was obtained from the patients and the Bioethics Committee of the Medical University in Lodz approved the study protocol (RNN/45/12/KB).

Tests were conducted in accordance with the Declaration of Helsinki and with the principles of Good Clinical Practice.

Statistical analysis All parameters were checked for normality using the Shapiro-Wilk test. Wilcoxon’s rank sum test was used for the comparison of basal treatment differences between each liver enzyme level.

 

Comparison of parameters in four time series was calculated using ANOVA Friedman test. Mann-Whitney U test was used for nonparametric data to perform the comparison between groups. Calculation were made using Statistical 9.1 Microsoft Co. software, and statistical significance was established at p< 0,05.

Acknowledgments This work was supported by the grant from the Polish Ministry of Science and Higher Education No: NN 402 54 37/40.

Competing Interests The authors declare that they have no competing interests.

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ACE (ACE 1, ACE T, ACE_HUMAN, ACE1, Angiotensin Converting Enzyme Somatic Isoform, Angiotensin Converting Enzyme Testis Specific Isoform, Angiotensin I Converting Enzyme, Angiotensin I Converting Enzyme 1, Angiotensin I Converting Enzyme Peptidyl Dipeptid

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ACE (ACE 1, ACE T, ACE_HUMAN, ACE1, Angiotensin Converting Enzyme Somatic Isoform, Angiotensin Converting Enzyme Testis Specific Isoform, Angiotensin I Converting Enzyme, Angiotensin I Converting Enzyme 1, Angiotensin I Converting Enzyme Peptidyl Dipeptid

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ACE (ACE 1, ACE T, ACE_HUMAN, ACE1, Angiotensin Converting Enzyme Somatic Isoform, Angiotensin Converting Enzyme Testis Specific Isoform, Angiotensin I Converting Enzyme, Angiotensin I Converting Enzyme 1, Angiotensin I Converting Enzyme Peptidyl Dipeptid

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ACE (ACE 1, ACE T, ACE_HUMAN, ACE1, Angiotensin Converting Enzyme Somatic Isoform, Angiotensin Converting Enzyme Testis Specific Isoform, Angiotensin I Converting Enzyme, Angiotensin I Converting Enzyme 1, Angiotensin I Converting Enzyme Peptidyl Dipeptid

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ACE (ACE 1, ACE T, ACE_HUMAN, ACE1, Angiotensin Converting Enzyme Somatic Isoform, Angiotensin Converting Enzyme Testis Specific Isoform, Angiotensin I Converting Enzyme, Angiotensin I Converting Enzyme 1, Angiotensin I Converting Enzyme Peptidyl Dipeptid

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ACE (ACE 1, ACE T, ACE_HUMAN, ACE1, Angiotensin Converting Enzyme Somatic Isoform, Angiotensin Converting Enzyme Testis Specific Isoform, Angiotensin I Converting Enzyme, Angiotensin I Converting Enzyme 1, Angiotensin I Converting Enzyme Peptidyl Dipeptid

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ACE (ACE 1, ACE T, ACE_HUMAN, ACE1, Angiotensin Converting Enzyme Somatic Isoform, Angiotensin Converting Enzyme Testis Specific Isoform, Angiotensin I Converting Enzyme, Angiotensin I Converting Enzyme 1, Angiotensin I Converting Enzyme Peptidyl Dipeptid

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ACE (ACE 1, ACE T, ACE_HUMAN, ACE1, Angiotensin Converting Enzyme Somatic Isoform, Angiotensin Converting Enzyme Testis Specific Isoform, Angiotensin I Converting Enzyme, Angiotensin I Converting Enzyme 1, Angiotensin I Converting Enzyme Peptidyl Dipeptid

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ACE (ACE 1, ACE T, ACE_HUMAN, ACE1, Angiotensin Converting Enzyme Somatic Isoform, Angiotensin Converting Enzyme Testis Specific Isoform, Angiotensin I Converting Enzyme, Angiotensin I Converting Enzyme 1, Angiotensin I Converting Enzyme Peptidyl Dipeptid

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ACE (ACE 1, ACE T, ACE_HUMAN, ACE1, Angiotensin Converting Enzyme Somatic Isoform, Angiotensin Converting Enzyme Testis Specific Isoform, Angiotensin I Converting Enzyme, Angiotensin I Converting Enzyme 1, Angiotensin I Converting Enzyme Peptidyl Dipeptid

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ACE (ACE 1, ACE T, ACE_HUMAN, ACE1, Angiotensin Converting Enzyme Somatic Isoform, Angiotensin Converting Enzyme Testis Specific Isoform, Angiotensin I Converting Enzyme, Angiotensin I Converting Enzyme 1, Angiotensin I Converting Enzyme Peptidyl Dipeptid

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ACE (ACE 1, ACE T, ACE_HUMAN, ACE1, Angiotensin Converting Enzyme Somatic Isoform, Angiotensin Converting Enzyme Testis Specific Isoform, Angiotensin I Converting Enzyme, Angiotensin I Converting Enzyme 1, Angiotensin I Converting Enzyme Peptidyl Dipeptid

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ACE (ACE 1, ACE T, ACE_HUMAN, ACE1, Angiotensin Converting Enzyme Somatic Isoform, Angiotensin Converting Enzyme Testis Specific Isoform, Angiotensin I Converting Enzyme, Angiotensin I Converting Enzyme 1, Angiotensin I Converting Enzyme Peptidyl Dipeptid

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Angiotensin Converting Enzyme 2 (CT) (ACE 2, ACE2, ACE-2, ACE-related Carboxypeptidase, Angiotensin Converting Enzyme Homolog, ACEH, Angiotensin Converting Enzyme-like Protein, Angiotensin I Converting Enzyme (Peptidyl Dipeptidase A) 2, Angiotensin I Conv

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Angiotensin Converting Enzyme 2 (CT) (ACE 2, ACE2, ACE-2, ACE-related Carboxypeptidase, Angiotensin Converting Enzyme Homolog, ACEH, Angiotensin Converting Enzyme-like Protein, Angiotensin I Converting Enzyme (Peptidyl Dipeptidase A) 2, Angiotensin I Conv

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Angiotensin Converting Enzyme 2 (CT) (ACE 2, ACE2, ACE-2, ACE-related Carboxypeptidase, Angiotensin Converting Enzyme Homolog, ACEH, Angiotensin Converting Enzyme-like Protein, Angiotensin I Converting Enzyme (Peptidyl Dipeptidase A) 2, Angiotensin I Conv

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Angiotensin Converting Enzyme 2 (CT) (ACE 2, ACE2, ACE-2, ACE-related Carboxypeptidase, Angiotensin Converting Enzyme Homolog, ACEH, Angiotensin Converting Enzyme-like Protein, Angiotensin I Converting Enzyme (Peptidyl Dipeptidase A) 2, Angiotensin I Conv

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Angiotensin Converting Enzyme 2 (CT) (ACE 2, ACE2, ACE-2, ACE-related Carboxypeptidase, Angiotensin Converting Enzyme Homolog, ACEH, Angiotensin Converting Enzyme-like Protein, Angiotensin I Converting Enzyme (Peptidyl Dipeptidase A) 2, Angiotensin I Conv

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Angiotensin Converting Enzyme 2 (CT) (ACE 2, ACE2, ACE-2, ACE-related Carboxypeptidase, Angiotensin Converting Enzyme Homolog, ACEH, Angiotensin Converting Enzyme-like Protein, Angiotensin I Converting Enzyme (Peptidyl Dipeptidase A) 2, Angiotensin I Conv

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Angiotensin Converting Enzyme 2 (CT) (ACE 2, ACE2, ACE-2, ACE-related Carboxypeptidase, Angiotensin Converting Enzyme Homolog, ACEH, Angiotensin Converting Enzyme-like Protein, Angiotensin I Converting Enzyme (Peptidyl Dipeptidase A) 2, Angiotensin I Conv

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Angiotensin Converting Enzyme 2 (CT) (ACE 2, ACE2, ACE-2, ACE-related Carboxypeptidase, Angiotensin Converting Enzyme Homolog, ACEH, Angiotensin Converting Enzyme-like Protein, Angiotensin I Converting Enzyme (Peptidyl Dipeptidase A) 2, Angiotensin I Conv

MBS6463189-5x01mL 5x0.1mL
EUR 4955

Angiotensin Converting Enzyme 2 (CT) (ACE 2, ACE2, ACE-2, ACE-related Carboxypeptidase, Angiotensin Converting Enzyme Homolog, ACEH, Angiotensin Converting Enzyme-like Protein, Angiotensin I Converting Enzyme (Peptidyl Dipeptidase A) 2, Angiotensin I Conv

MBS6463190-01mL 0.1mL
EUR 1135

Angiotensin Converting Enzyme 2 (CT) (ACE 2, ACE2, ACE-2, ACE-related Carboxypeptidase, Angiotensin Converting Enzyme Homolog, ACEH, Angiotensin Converting Enzyme-like Protein, Angiotensin I Converting Enzyme (Peptidyl Dipeptidase A) 2, Angiotensin I Conv

MBS6463190-5x01mL 5x0.1mL
EUR 4955

Angiotensin Converting Enzyme 2 (CT) (ACE 2, ACE2, ACE-2, ACE-related Carboxypeptidase, Angiotensin Converting Enzyme Homolog, ACEH, Angiotensin Converting Enzyme-like Protein, Angiotensin I Converting Enzyme (Peptidyl Dipeptidase A) 2, Angiotensin I Conv

MBS6463191-01mL 0.1mL
EUR 1135

Angiotensin Converting Enzyme 2 (CT) (ACE 2, ACE2, ACE-2, ACE-related Carboxypeptidase, Angiotensin Converting Enzyme Homolog, ACEH, Angiotensin Converting Enzyme-like Protein, Angiotensin I Converting Enzyme (Peptidyl Dipeptidase A) 2, Angiotensin I Conv

MBS6463191-5x01mL 5x0.1mL
EUR 4955

Angiotensin Converting Enzyme 2 (CT) (ACE 2, ACE2, ACE-2, ACE-related Carboxypeptidase, Angiotensin Converting Enzyme Homolog, ACEH, Angiotensin Converting Enzyme-like Protein, Angiotensin I Converting Enzyme (Peptidyl Dipeptidase A) 2, Angiotensin I Conv

MBS6463192-01mL 0.1mL
EUR 1135

Angiotensin Converting Enzyme 2 (CT) (ACE 2, ACE2, ACE-2, ACE-related Carboxypeptidase, Angiotensin Converting Enzyme Homolog, ACEH, Angiotensin Converting Enzyme-like Protein, Angiotensin I Converting Enzyme (Peptidyl Dipeptidase A) 2, Angiotensin I Conv

MBS6463192-5x01mL 5x0.1mL
EUR 4955

Angiotensin Converting Enzyme 2 (CT) (ACE 2, ACE2, ACE-2, ACE-related Carboxypeptidase, Angiotensin Converting Enzyme Homolog, ACEH, Angiotensin Converting Enzyme-like Protein, Angiotensin I Converting Enzyme (Peptidyl Dipeptidase A) 2, Angiotensin I Conv

MBS6463193-01mL 0.1mL
EUR 1135

Angiotensin Converting Enzyme 2 (CT) (ACE 2, ACE2, ACE-2, ACE-related Carboxypeptidase, Angiotensin Converting Enzyme Homolog, ACEH, Angiotensin Converting Enzyme-like Protein, Angiotensin I Converting Enzyme (Peptidyl Dipeptidase A) 2, Angiotensin I Conv

MBS6463193-5x01mL 5x0.1mL
EUR 4955

Angiotensin Converting Enzyme 2 (CT) (ACE 2, ACE2, ACE-2, ACE-related Carboxypeptidase, Angiotensin Converting Enzyme Homolog, ACEH, Angiotensin Converting Enzyme-like Protein, Angiotensin I Converting Enzyme (Peptidyl Dipeptidase A) 2, Angiotensin I Conv

MBS6463194-01mL 0.1mL
EUR 1135

Angiotensin Converting Enzyme 2 (CT) (ACE 2, ACE2, ACE-2, ACE-related Carboxypeptidase, Angiotensin Converting Enzyme Homolog, ACEH, Angiotensin Converting Enzyme-like Protein, Angiotensin I Converting Enzyme (Peptidyl Dipeptidase A) 2, Angiotensin I Conv

MBS6463194-5x01mL 5x0.1mL
EUR 4955

Angiotensin Converting Enzyme 2 (CT) (ACE 2, ACE2, ACE-2, ACE-related Carboxypeptidase, Angiotensin Converting Enzyme Homolog, ACEH, Angiotensin Converting Enzyme-like Protein, Angiotensin I Converting Enzyme (Peptidyl Dipeptidase A) 2, Angiotensin I Conv

MBS6463195-01mL 0.1mL
EUR 1135

Angiotensin Converting Enzyme 2 (CT) (ACE 2, ACE2, ACE-2, ACE-related Carboxypeptidase, Angiotensin Converting Enzyme Homolog, ACEH, Angiotensin Converting Enzyme-like Protein, Angiotensin I Converting Enzyme (Peptidyl Dipeptidase A) 2, Angiotensin I Conv

MBS6463195-5x01mL 5x0.1mL
EUR 4955

Angiotensin Converting Enzyme 2 (CT) (ACE 2, ACE2, ACE-2, ACE-related Carboxypeptidase, Angiotensin Converting Enzyme Homolog, ACEH, Angiotensin Converting Enzyme-like Protein, Angiotensin I Converting Enzyme (Peptidyl Dipeptidase A) 2, Angiotensin I Conv

MBS6463196-01mL 0.1mL
EUR 1135

Angiotensin Converting Enzyme 2 (CT) (ACE 2, ACE2, ACE-2, ACE-related Carboxypeptidase, Angiotensin Converting Enzyme Homolog, ACEH, Angiotensin Converting Enzyme-like Protein, Angiotensin I Converting Enzyme (Peptidyl Dipeptidase A) 2, Angiotensin I Conv

MBS6463196-5x01mL 5x0.1mL
EUR 4955

Angiotensin Converting Enzyme 2

MBS8534070-01mL 0.1mL
EUR 375

Angiotensin Converting Enzyme 2

MBS8534070-01mLAF405L 0.1mL(AF405L)
EUR 595

Angiotensin Converting Enzyme 2

MBS8534070-01mLAF405S 0.1mL(AF405S)
EUR 595

Angiotensin Converting Enzyme 2

MBS8534070-01mLAF610 0.1mL(AF610)
EUR 595

Angiotensin Converting Enzyme 2

MBS8534070-01mLAF635 0.1mL(AF635)
EUR 595

ACE (angiotensin converting enzyme)

MBS8534923-01mL 0.1mL
EUR 305

ACE (angiotensin converting enzyme)

MBS8534923-01mLAF405L 0.1mL(AF405L)
EUR 565

ACE (angiotensin converting enzyme)

MBS8534923-01mLAF405S 0.1mL(AF405S)
EUR 565

ACE (angiotensin converting enzyme)

MBS8534923-01mLAF610 0.1mL(AF610)
EUR 565

ACE (angiotensin converting enzyme)

MBS8534923-01mLAF635 0.1mL(AF635)
EUR 565

Rabbit Angiotensin I Converting Enzyme (ACE) Enzyme

abx077001-025U 0.25 U
EUR 543.6

Angiotensin Converting Enzyme, Rat (ACE)

MBS653765-1Unit 1Unit
EUR 925

Angiotensin Converting Enzyme, Rat (ACE)

MBS653765-5x1Unit 5x1Unit
EUR 4015

Angiotensin Converting Enzyme Inhibitor

5-00679 4 x 5mg Ask for price

Angiotensin Converting Enzyme Inhibitor

GWB-80222D 5 mg Ask for price

Angiotensin Converting Enzyme (ACE, CD143)

MBS6506995-01mg 0.1mg
EUR 815

Angiotensin Converting Enzyme (ACE, CD143)

MBS6506995-5x01mg 5x0.1mg
EUR 3510

Angiotensin Converting Enzyme (ACE, CD143)

MBS6506996-01mg 0.1mg
EUR 675

Angiotensin Converting Enzyme (ACE, CD143)

MBS6506996-5x01mg 5x0.1mg
EUR 2900

ACE (Angiotensin Converting Enzyme) Rabbit

GWB-746676 1 Units Ask for price

Angiotensin Converting Enzyme 2 Antibody

49072 100ul
EUR 499

Angiotensin Converting Enzyme 2 Antibody

49072-100ul 100ul
EUR 399.6

Angiotensin Converting Enzyme 2 Antibody

49072-50ul 50ul
EUR 286.8

Angiotensin Converting Enzyme 1 Antibody

E2200471 100ug
EUR 225
Description: Available in various conjugation types.

Angiotensin Converting Enzyme 1 Antibody

MBS8505128-01mg 0.1mg
EUR 305

Angiotensin Converting Enzyme 1 Antibody

MBS8505128-01mLAF405L 0.1mL(AF405L)
EUR 565

Angiotensin Converting Enzyme 1 Antibody

MBS8505128-01mLAF405S 0.1mL(AF405S)
EUR 565

Angiotensin Converting Enzyme 1 Antibody

MBS8505128-01mLAF610 0.1mL(AF610)
EUR 565

Angiotensin Converting Enzyme 1 Antibody

MBS8505128-01mLAF635 0.1mL(AF635)
EUR 565

Angiotensin Converting Enzyme 2 Antibody

MBS9435848-005mL 0.05mL
EUR 325

Angiotensin Converting Enzyme 2 Antibody

MBS9435848-01mL 0.1mL
EUR 435

Angiotensin Converting Enzyme 2 Antibody

MBS9435848-5x01mL 5x0.1mL
EUR 1810

ACE (angiotensin converting enzyme) Antibody

E8RT1013 100ul
EUR 225
Description: Available in various conjugation types.

Angiotensin Converting Enzyme Antibody (ACE)

F50773-0.08ML 0.08 ml
EUR 140.25
Description: ACE is an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes - the somatic form and the testicular form that are equally active.

Angiotensin Converting Enzyme (ACE), Antibody

GWB-927AC1 0.1 mg Ask for price

Angiotensin Converting Enzyme (ACE), Antibody

GWB-949248 0.1 mg Ask for price

ACE Antibody [Angiotensin Converting Enzyme]

R31318 100 ug
EUR 356.15
Description: Angiotensin converting enzyme, also called DCP or CD143, is a zinc-containing dipeptidyl carboxypeptidase widely distributed in mammalian tissues and is though to play a critical role in blood pressure regulation. The ACE gene is mapped to 17q23.3. This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies.

Angiotensin Converting Enzyme Antibody (ACE)

R31319 100 ug
EUR 356.15
Description: Angiotensin converting enzyme (ACE), also called DCP or CD143 is a zinc-containing dipeptidyl carboxypeptidase widely distributed in mammalian tissues and is though to play a critical role in blood pressure regulation. This gene is mapped to 17q23.3. This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II.

Angiotensin Converting Enzyme 1 Mouse mAb

27059 100ul
EUR 319

Angiotensin I Converting Enzyme (ACE)/CD143

MBS4380833-002mgWithBSAAzideat02mgmL 0.02mg(WithBSA&Azideat0.2mg/mL)
EUR 230

Angiotensin I Converting Enzyme (ACE)/CD143

MBS4380833-01mgWithBSAAzideat02mgmL 0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 405

Angiotensin I Converting Enzyme (ACE)/CD143

MBS4380833-01mgWithoutBSAAzideat1mgmL 0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 405

Angiotensin I Converting Enzyme (ACE)/CD143

MBS4380833-5x01mgWithBSAAzideat02mgmL 5x0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 1725

Angiotensin I Converting Enzyme (ACE)/CD143

MBS4380833-5x01mgWithoutBSAAzideat1mgmL 5x0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 1725

Angiotensin I Converting Enzyme (ACE)/CD143

MBS4381619-002mgWithBSAAzideat02mgmL 0.02mg(WithBSA&Azideat0.2mg/mL)
EUR 230

Angiotensin I Converting Enzyme (ACE)/CD143

MBS4381619-01mgWithBSAAzideat02mgmL 0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 405

Angiotensin I Converting Enzyme (ACE)/CD143

MBS4381619-01mgWithoutBSAAzideat1mgmL 0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 405

Angiotensin I Converting Enzyme (ACE)/CD143

MBS4381619-5x01mgWithBSAAzideat02mgmL 5x0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 1725

Angiotensin I Converting Enzyme (ACE)/CD143

MBS4381619-5x01mgWithoutBSAAzideat1mgmL 5x0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 1725

Angiotensin I Converting Enzyme (ACE)/CD143

MBS4381655-002mgWithBSAAzideat02mgmL 0.02mg(WithBSA&Azideat0.2mg/mL)
EUR 230

Angiotensin I Converting Enzyme (ACE)/CD143

MBS4381655-01mgWithBSAAzideat02mgmL 0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 405

Angiotensin I Converting Enzyme (ACE)/CD143

MBS4381655-01mgWithoutBSAAzideat1mgmL 0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 405

Angiotensin I Converting Enzyme (ACE)/CD143

MBS4381655-5x01mgWithBSAAzideat02mgmL 5x0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 1725
Dylan