caspase-14

The Effects of Melatonin on Elevated Liver Enzymes During Statins Treatment

Introduction Statins are widely used in the treatment and prevention of lipid metabolism disorders. They are generally well tolerated but not devoid of side effects. These include, among others, muscular symptoms, arthritis, headaches, gynecomastia. Myositis and rhabdomyolysis associated with increased activity of creatinine kinase and serum creatinine levels are rare but serious adverse events of statin therapy.

  • The risk of these complications is increased in elderly patients with chronic diseases and in alcohol abusers.
  • Furthermore, statins cause hepatotoxic effect which is observed in several percent of treated patients, usually in the first weeks of the therapy . Most frequently it is manifested by asymptomatic increase in the level of aspartate and alanine aminotransferase.
  • This is usually a temporary increase, but in some patients the level of these enzymes exceeds 3 times the normal limit, which is a matter of concern. In such cases, patients expect the decision to discontinue the treatment or to administer hepatoprotective drugs.
  • Acetylcholine, sylibinin, phospholipids and other drugs used for this purpose are not always effective. Therefore, there is still search for alternative drugs for the protection of liver.

In own study melatonin was used for this purpose because previous experimental studies had demonstrated that it protected liver against harmful effects of many toxic agents as well as the consequences of ischemia-reperfusion model.

The liver is an organ in which there comes to intensive metabolic and detoxification processes. In their course large amounts of reactive oxygen species are generated and they exert a toxic effect on hepatocytes.
A complex antioxidant system – in which metabolized there melatonin (pineal and from other sources) is an important part – prevents that.

The main melatonin metabolic pathway in the liver is through hydroxylation pathway at the C-6 position by 6-hydroxylase and P450 cytochromes (CYP1A1, CYP1A2, CYP2P19, CYP1B1 isozymes). The 6-hydroxymelatonin, formed in this process, is conjugated with sulphate and glucuronide to 6-hydroxymelatonin sulphate or glucuronide. In this process melatonin and its metabolites exert high antioxidant activity.

An alternative metabolic pathway includes melatonin oxidation to N-acetyl-formyl-5- methoxykynuramine (AFMK) and N-acetyl-5-methoxykynuramine (AMK). The kynurenine pathway of melatonin metabolism leads to formation of a series of free radical scavengers.

Furthermore, melatonin decreases the production of proinflammatory cytokines and inhibits hepatic fibrogenesis. Owing to its multidirectional action in liver, apoptosis and necrosis decrease, the integrity is protected and regeneration is improved.

caspase-14

caspase-14

Cortisol Enzyme Immunoassay kit - 5 Strip plates

K003-H5 5x96 well plate
EUR 1055

Cortisol Enzyme Immunoassay kit - 5 Whole plates

K003-H5W 5x96 well plate
EUR 1055

Human Estrone-3-Glucuronide (E1G)Enzyme Immunoassay ELISA Kit

QY-E05423 96T
EUR 361

NATtrol Zika Virus Stock (Qualitative) (1 mL)

TEST 1 mL
EUR 1106.64
Description: Please contact Gentaur in order to receive the datasheet of the product.

SARS-CoV-2 Antigen Rapid Test Kit (Colloidal gold Immunoassay)

CoV2Ag-25 25 Tests/Kit
EUR 35
Description: This SARS-CoV-2 Antigen Rapid Test Kit (Colloidal Gold) uses the sandwich immunocapture method and colloidal gold immunochromatography to qualitatively determine the presence of SARS-CoV-2 antigens in human oropharyngeal swabs, nasal swabs and nasopharyngeal swabs. It is helpful as an aid in the screening of early mild, asymptomatic, or acute patients for identification of SARS-CoV-2 infection.

Anti-SARS-CoV-2 Neutralization Antibody Test Kit (Colloidal gold immunoassay)

CP04010 25T/kit Ask for price
Description: The Anti-SARS-CoV-2 Neutralization Antibody Test Kit (Serum/Plasma/Whole blood) is a qualitative membrane-based immunoassay for the detection of SARS-CoV-2 neutralizing antibodies in serum, plasma and whole blood. The sample is dropped into the sample well, and chromatography is performed under the capillary effect. The SARS-CoV-2 neutralizing antibodies in the sample combined with the colloidal gold-labeled SARS-CoV-2 spike protein(SP), then spread to the test area. It is captured by coated SP subunit RBDNTD-CTD, to form a complex and gather in the test area (T line). The quality control area is coated with mouse anti-chicken IgY, and the colloidal goldlabeled chicken IgY is captureed to form a complex and aggregate in hte quality control area (C line). If the C line does not show color, it indicates that the result is invalid, and this sample need to be tested again.

Human FE(Ferritin) ELISA Kit

EH0382 96T
EUR 476.25
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml

Immunoassay Stabilizer

85R-103 1 liter
EUR 481
Description: Stabilizing buffer for use in immunoassays

Human FTMT(Ferritin, mitochondrial) ELISA Kit

EH1479 96T
EUR 567.6
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.375 ng/ml

Cystatin C Immunoassay Kit

K012-H1 1x96 well plate
EUR 405

11,12-DHET Immunoassay Kit

DH4 1 Kit
EUR 307

Human Albumin AssayLite Fluorescent Immunoassay Kit

FEA2201 96 Well Plate
EUR 396

Human Ceruloplasmin AssayLite Fluorescent Immunoassay Kit

FEC5201 96 Well Plate
EUR 396

Human Haptoglobin AssayLite Fluorescent Immunoassay Kit

FEH1003 96 Well Plate
EUR 396

Human IgA AssayLite Fluorescent Immunoassay Kit

FEI7001 96 Well Plate
EUR 396

Human IgG AssayLite Fluorescent Immunoassay Kit

FEI7200 96 Well Plate
EUR 396

Human IgM AssayLite Fluorescent Immunoassay Kit

FEI7301 96 Well Plate
EUR 396

Human Prealbumin AssayLite Fluorescent Immunoassay Kit

FEP2010 96 Well Plate
EUR 396

Human FTH1(Ferritin heavy chain ) ELISA Kit

EH0488 96T
EUR 476.25
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 46.875pg/ml

Human FTL(Ferritin light chain ) ELISA Kit

EH0492 96T
EUR 476.25
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 1.875 ng/ml

Mouse FE(Ferritin) ELISA Kit

EM1019 96T
EUR 476.25
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.281 ng/ml

Monkey FE(Ferritin) ELISA Kit

EMK0022 96T
EUR 567.6
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Ape;Sensitivity: 4.688 ng/ml

Rat FE(Ferritin) ELISA Kit

ER0947 96T
EUR 476.25
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 1.875pg/ml

CaspSELECT Caspase 3 Immunoassay Kit

55R-1338 100 assays
EUR 1022
Description: Assay Kit for detection of Capase 3 activity in the research laboratory

cAMP Direct Immunoassay Kit (Colorimetric)

K371-100
EUR 512

cGMP Direct Immunoassay Kit (Colorimetric)

K372-100
EUR 512

QuickTiter Adenovirus Titer Immunoassay Kit

VPK-109 100 assays
EUR 705
Description: Accurate measurement of adenovirus titer is critical for gene delivery. Traditional plaque-forming unit (PFU) assays are long and suffer from high inter-assay variability. The QuickTiter Adenovirus Titer Immunoassay Kit provide a quick, complete system to functionally titer virus infectivity. The assay recognizes all 41 serotypes of adenovirus, and can be used with any adenovirus system that can amplify in HEK 293 cells.

cAMP Direct Immunoassay Kit (Colorimetric)

K2044-100 100 assays
EUR 529

cGMP Direct Immunoassay Kit (Colorimetric)

K2066-100 100 assays
EUR 529

anti- Ferritin antibody

FNab09810 100µg
EUR 548.75
Description: Antibody raised against Ferritin

Human Complement C3 AssayLite Fluorescent Immunoassay Kit

FEC2101 96 Well Plate
EUR 396

Human Complement C4 AssayLite Fluorescent Immunoassay Kit

FEC2102 96 Well Plate
EUR 396

Human Fibrinogen (FBG) AssayLite Fluorescent Immunoassay Kit

FEF1040 96 Well Plate
EUR 396

Human IDE(Insulin-degrading enzyme) ELISA Kit

EH1988 96T
EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 37.5pg/ml

Human Ferritin ELISA kit

E01F0010-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Human Ferritin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ferritin ELISA kit

E01F0010-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Human Ferritin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ferritin ELISA kit

E01F0010-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Human Ferritin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ferritin ELISA Kit

E-80F 1 x 96 well plate
EUR 385

Human Ferritin ELISA kit

LF-EK0149 1×96T
EUR 603

Ferritin (human) ELISA Kit

K7420-100
EUR 805

Immunoassay Stabilizer (BSA free)

85R-103BF 1 liter
EUR 481
Description: BSA Free Stabilizing buffer for use in immunoassays

Recombinant human Glycogen debranching enzyme

P2412 100ug Ask for price
Description: Recombinant protein for human Glycogen debranching enzyme

CaspSELECT? Caspase-3 Immunoassay Kit (Fluorometric)

K163-100
EUR 751

Mouse Albumin AssayLite Fluorescent Immunoassay Kit

FEMA2201 96 Well Plate
EUR 396

Rat Albumin AssayLite Fluorescent Immunoassay Kit

FERA2201 96 Well Plate
EUR 396

Rat Fth1(Ferritin heavy chain) ELISA Kit

ER0090 96T
EUR 567.6
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 3.75 ng/ml

Human UBE2C(Ubiquitin Conjugating Enzyme E2C) ELISA Kit

EH3939 96T
EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml

Human ACE(Angiotensin I Converting Enzyme) ELISA Kit

EH0026 96T
EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.469 ng/ml

Human ACE2(Angiotensin-converting enzyme 2) ELISA Kit

EH0027 96T
EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.234 ng/ml

Human UBE2I(SUMO-conjugating enzyme UBC9) ELISA Kit

EH1264 96T
EUR 567.6
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml

Human APEH(Acylamino-acid-releasing enzyme) ELISA Kit

EH1573 96T
EUR 567.6
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml

Human ECE1(Endothelin-converting enzyme 1) ELISA Kit

EH2454 96T
EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml

Anti-SARS-CoV-2 Neutralization Antibody Test Kit (Enzyme-linked immunosorbent assay)

CP04012 96T/5*96T Ask for price
Description: It is a semi quantitative competition ELISA kit to detect the Anti-SARS-CoV-2 Neutralization Antibody in human serum or plasma. The micro test plate provided in this kit is pre-coated with recombinant human ACE2. During the reaction, the SARS-CoV-2 neutralization antibody in the standard & sample diluent pretreated samples or controls competes with a fixed amount of human ACE2 on the solid phase supporter for sites on the Horseradish peroxidase (HRP) conjugated recombinant SARS-CoV-2 RBD fragment (HRP-RBD). After 37℃incubation, the unbound HRP-RBD as well as any HRP-RBD bound to non-neutralization antibody will be captured on the plate and eventually form the ACE2-RBD-HRP complex, while the circulating neutralization antibodies HRP-RBD complexes remain in the supernatant and are removed during washing. Then a TMB substrate solution is added to each well. The enzyme-substrate reaction is terminated by the addition of stop solution and the color change is measured spectrophotometrically at a wavelength of 450 nm ± 2 nm.

(1-Kit )11,12-EET/DHET Immunoassay Kit

DH5 1 Kit
EUR 307

Human Alpha-1-Antitrypsin AssayLite Fluorescent Immunoassay Kit

FEA5101 96 Well Plate
EUR 396

Human Ferritin depleted/stripped serum (Ferritin

1810-FDS-10 10 ml Ask for price

Human Ferritin depleted/stripped serum (Ferritin

1810-FDS-1000 1000 ml Ask for price

anti- Ferritin light chain antibody

FNab03079 100µg
EUR 505.25
Description: Antibody raised against Ferritin light chain

Recombinant human Acylamino-acid-releasing enzyme

P1835 100ug Ask for price
Description: Recombinant protein for human Acylamino-acid-releasing enzyme

Melamine Rapid Test Kit

abx092011-50tests 50 tests
EUR 370

NDV rapid test kit

RG15-03 1 box
EUR 139.05
Description: Please check the datasheet of NDV rapid test kit before using the test.

Human UBE2A(Ubiquitin-conjugating enzyme E2 A) ELISA Kit

EH1106 96T
EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.188 ng/ml

Human SAE1(SUMO-activating enzyme subunit 1) ELISA Kit

EH2266 96T
EUR 567.6
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml

Nitric Oxide Synthase (NOS) enzyme assay, colorimetric micro assay kit, 96 test, Quantitative

1290-NOS-1 1 kit
EUR 651

Ferritin ELISA kit

55R-1881 1 kit
EUR 743
Description: ELISA kit for the detection of Ferritin in the research laboratory

Ferritin ELISA kit

55R-ORG5FE 96 wells
EUR 346
Description: ELISA kit for the detection of Ferritin in the research laboratory

Frit Kit

FRIT-KIT 1each
EUR 124
Description: Kit to create frits in capillaries. Includes formamide, Kasil-1, Kasil-1624 and a cleaving tool.

QuickTiter Adenovirus Titer Immunoassay Kit, Trial Size

VPK-109-T 20 assays
EUR 374
Description: Accurate measurement of adenovirus titer is critical for gene delivery. Traditional plaque-forming unit (PFU) assays are long and suffer from high inter-assay variability. The QuickTiter Adenovirus Titer Immunoassay Kit provide a quick, complete system to functionally titer virus infectivity. The assay recognizes all 41 serotypes of adenovirus, and can be used with any adenovirus system that can amplify in HEK 293 cells.

Human Carcinoembryonic Ferritin ELISA Kit

ELA-E1376h 96 Tests
EUR 824

Human ferritin,FE ELISA Kit

CN-04117H1 96T
EUR 434

Human ferritin,FE ELISA Kit

CN-04117H2 48T
EUR 284

Human Glycosylated Ferritin ELISA kit

E01G0017-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Human Glycosylated Ferritin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Glycosylated Ferritin ELISA kit

E01G0017-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Human Glycosylated Ferritin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Glycosylated Ferritin ELISA kit

E01G0017-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Human Glycosylated Ferritin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human H ferritin ELISA kit

E01H0243-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Human H ferritin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human H ferritin ELISA kit

E01H0243-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Human H ferritin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human H ferritin ELISA kit

E01H0243-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Human H ferritin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Carcinoembryonic Ferritin ELISA kit

E01C0729-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Human Carcinoembryonic Ferritin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Carcinoembryonic Ferritin ELISA kit

E01C0729-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Human Carcinoembryonic Ferritin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Carcinoembryonic Ferritin ELISA kit

E01C0729-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Human Carcinoembryonic Ferritin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ferritin (FE)CLIA Kit

SCA518Hu-10x96wellstestplate 10x96-wells test plate
EUR 5647.8
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Ferritin (FE) in serum, plasma, tissue homogenates, cell culture supernates and other biological fluids.

Human Ferritin (FE)CLIA Kit

SCA518Hu-1x48wellstestplate 1x48-wells test plate
EUR 552.76
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Ferritin (FE) in serum, plasma, tissue homogenates, cell culture supernates and other biological fluids.

Human Ferritin (FE)CLIA Kit

SCA518Hu-1x96wellstestplate 1x96-wells test plate
EUR 746.8
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Ferritin (FE) in serum, plasma, tissue homogenates, cell culture supernates and other biological fluids.

Human Ferritin (FE)CLIA Kit

SCA518Hu-5x96wellstestplate 5x96-wells test plate
EUR 3060.6
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Ferritin (FE) in serum, plasma, tissue homogenates, cell culture supernates and other biological fluids.

Human Ferritin (FE) CLIA Kit

4-SCA518Hu
  • EUR 5698.00
  • EUR 3061.00
  • EUR 747.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Human Ferritin (FE)Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

Human Ferritin (FE) ELISA Kit

SEA518Hu-10x96wellstestplate 10x96-wells test plate
EUR 2637.1
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Ferritin (FE) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Ferritin (FE) ELISA Kit

SEA518Hu-1x48wellstestplate 1x48-wells test plate
EUR 304.82
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Ferritin (FE) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Ferritin (FE) ELISA Kit

SEA518Hu-1x96wellstestplate 1x96-wells test plate
EUR 392.6
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Ferritin (FE) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Ferritin (FE) ELISA Kit

SEA518Hu-5x96wellstestplate 5x96-wells test plate
EUR 1466.7
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Ferritin (FE) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Ferritin (FE) ELISA Kit

4-SEA518Hu
  • EUR 2688.00
  • EUR 1417.00
  • EUR 393.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Ferritin (FE) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species.

Human Ferritin ELISA kit (4X96T)

LF-EK0150 4×96T
EUR 2045

Human Ferritin ELISA kit (10X96T)

LF-EK0151 10×96T
EUR 4484

Human Ferritin ELISA kit (20X96T)

LF-EK0152 20×96T
EUR 7808

The aim of this study was to assess the usefulness of melatonin in counteracting the adverse hepatic events from statins.

Material and Methods Patients and Data Collection The research program included 30 subjects, aged 47-68 years, 41 women and 23 men. All women were I the postpostmenopausal period. Recruitment and diagnostic tests were conducted in the Department of Gastroenterology, Medical University of Lodz and Outpatient Consulting Clinic “Gastro” in Lodz.

The research study was performed in the years 2012-2016. Therapeutic Procedures After inclusion into the study, all patients were recommended the same balanced diet with limited animal fats and simple carbohydrates of caloric content of 1600 kcal. At the same time, they were recommended to continue the treatment with the same statin at a daily dose of 20 mg.

The patients were randomly allocated into two groups. Group I (n=30) was recommended to take statin together with melatonin (LEK-AM, Poland) at a dose of 2×5 mg, at 7:00 a.m. and 9:00 p.m. In Group II (n=30) patients took statin with placebo (LEK-AM, Poland) at the same dose and time of the day.

Follow-up laboratory tests (AST, ALT, GGT, ALP, cholesterol and triglycerides) were evaluated after 2,4 and 6 months of treatment.

Ethical procedures A written consent was obtained from the patients and the Bioethics Committee of the Medical University in Lodz approved the study protocol (RNN/45/12/KB).

Tests were conducted in accordance with the Declaration of Helsinki and with the principles of Good Clinical Practice.

Statistical analysis All parameters were checked for normality using the Shapiro-Wilk test. Wilcoxon’s rank sum test was used for the comparison of basal treatment differences between each liver enzyme level.

 

Comparison of parameters in four time series was calculated using ANOVA Friedman test. Mann-Whitney U test was used for nonparametric data to perform the comparison between groups. Calculation were made using Statistical 9.1 Microsoft Co. software, and statistical significance was established at p< 0,05.

Acknowledgments This work was supported by the grant from the Polish Ministry of Science and Higher Education No: NN 402 54 37/40.

Competing Interests The authors declare that they have no competing interests.

Angiotensin Converting Enzyme 2 Antibody

49072-50ul 50ul
EUR 239

Human Angiotensin Converting Enzyme ELISA kit

E01A2159-192T 192 tests
EUR 1270
Description: A competitive for quantitative measurement of Human Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Angiotensin Converting Enzyme ELISA kit

E01A2159-48 1 plate of 48 wells
EUR 520
Description: A competitive for quantitative measurement of Human Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Angiotensin Converting Enzyme ELISA kit

E01A2159-96 1 plate of 96 wells
EUR 685
Description: A competitive for quantitative measurement of Human Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Angiotensin Converting Enzyme ELISA kit

E02A2159-192T 192 tests
EUR 1270
Description: A competitive for quantitative measurement of Rat Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Angiotensin Converting Enzyme ELISA kit

E02A2159-48 1 plate of 48 wells
EUR 520
Description: A competitive for quantitative measurement of Rat Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Angiotensin Converting Enzyme ELISA kit

E02A2159-96 1 plate of 96 wells
EUR 685
Description: A competitive for quantitative measurement of Rat Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Anti-Angiotensin Converting Enzyme 1 (6A4)

YF-MA12650 100 ug
EUR 363
Description: Mouse monoclonal to Angiotensin Converting Enzyme 1

Anti-Angiotensin Converting Enzyme 1 (4B10)

YF-MA12651 100 ug
EUR 363
Description: Mouse monoclonal to Angiotensin Converting Enzyme 1

Mouse Angiotensin Converting Enzyme ELISA kit

E03A2159-192T 192 tests
EUR 1270
Description: A competitive for quantitative measurement of Mouse Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Angiotensin Converting Enzyme ELISA kit

E03A2159-48 1 plate of 48 wells
EUR 520
Description: A competitive for quantitative measurement of Mouse Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Angiotensin Converting Enzyme ELISA kit

E03A2159-96 1 plate of 96 wells
EUR 685
Description: A competitive for quantitative measurement of Mouse Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Angiotensin Converting Enzyme ELISA kit

E04A2159-192T 192 tests
EUR 1270
Description: A competitive for quantitative measurement of Rabbit Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Angiotensin Converting Enzyme ELISA kit

E04A2159-48 1 plate of 48 wells
EUR 520
Description: A competitive for quantitative measurement of Rabbit Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Angiotensin Converting Enzyme ELISA kit

E04A2159-96 1 plate of 96 wells
EUR 685
Description: A competitive for quantitative measurement of Rabbit Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Recombinant Angiotensin I Converting Enzyme (ACE)

4-RPA004Hu01
  • EUR 444.06
  • EUR 222.00
  • EUR 1390.24
  • EUR 530.08
  • EUR 960.16
  • EUR 360.00
  • EUR 3325.60
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Angiotensin I Converting Enzyme expressed in: E.coli

Recombinant Angiotensin I Converting Enzyme (ACE)

4-RPA004Hu02
  • EUR 444.06
  • EUR 222.00
  • EUR 1390.24
  • EUR 530.08
  • EUR 960.16
  • EUR 360.00
  • EUR 3325.60
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Angiotensin I Converting Enzyme expressed in: E.coli

Recombinant Angiotensin I Converting Enzyme (ACE)

4-RPA004Mu01
  • EUR 476.32
  • EUR 230.00
  • EUR 1511.20
  • EUR 570.40
  • EUR 1040.80
  • EUR 382.00
  • EUR 3628.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Angiotensin I Converting Enzyme expressed in: E.coli

Recombinant Angiotensin I Converting Enzyme (ACE)

4-RPA004Mu02
  • EUR 476.32
  • EUR 230.00
  • EUR 1511.20
  • EUR 570.40
  • EUR 1040.80
  • EUR 382.00
  • EUR 3628.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Angiotensin I Converting Enzyme expressed in: E.coli

Recombinant Angiotensin I Converting Enzyme (ACE)

4-RPA004Mu03
  • EUR 476.32
  • EUR 230.00
  • EUR 1511.20
  • EUR 570.40
  • EUR 1040.80
  • EUR 382.00
  • EUR 3628.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Angiotensin I Converting Enzyme expressed in: E.coli

Recombinant Angiotensin I Converting Enzyme (ACE)

4-RPA004Po01
  • EUR 501.41
  • EUR 237.00
  • EUR 1605.28
  • EUR 601.76
  • EUR 1103.52
  • EUR 398.00
  • EUR 3863.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Pig Angiotensin I Converting Enzyme expressed in: E.coli

Recombinant Angiotensin I Converting Enzyme (ACE)

4-RPA004Rb01
  • EUR 530.08
  • EUR 245.00
  • EUR 1712.80
  • EUR 637.60
  • EUR 1175.20
  • EUR 418.00
  • EUR 4132.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rabbit Angiotensin I Converting Enzyme expressed in: E.coli

Monkey Angiotensin Converting Enzyme ELISA kit

E09A2159-192T 192 tests
EUR 1270
Description: A competitive for quantitative measurement of Monkey Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Angiotensin Converting Enzyme ELISA kit

E09A2159-48 1 plate of 48 wells
EUR 520
Description: A competitive for quantitative measurement of Monkey Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Angiotensin Converting Enzyme ELISA kit

E09A2159-96 1 plate of 96 wells
EUR 685
Description: A competitive for quantitative measurement of Monkey Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Angiotensin Converting Enzyme ELISA kit

E07A2159-192T 192 tests
EUR 1270
Description: A competitive for quantitative measurement of Porcine Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Angiotensin Converting Enzyme ELISA kit

E07A2159-48 1 plate of 48 wells
EUR 520
Description: A competitive for quantitative measurement of Porcine Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Angiotensin Converting Enzyme ELISA kit

E07A2159-96 1 plate of 96 wells
EUR 685
Description: A competitive for quantitative measurement of Porcine Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Angiotensin Converting Enzyme ELISA kit

E08A2159-192T 192 tests
EUR 1270
Description: A competitive for quantitative measurement of Canine Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Angiotensin Converting Enzyme ELISA kit

E08A2159-48 1 plate of 48 wells
EUR 520
Description: A competitive for quantitative measurement of Canine Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Angiotensin Converting Enzyme ELISA kit

E08A2159-96 1 plate of 96 wells
EUR 685
Description: A competitive for quantitative measurement of Canine Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Angiotensin Converting Enzyme ELISA kit

E06A2159-192T 192 tests
EUR 1270
Description: A competitive for quantitative measurement of Goat Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Angiotensin Converting Enzyme ELISA kit

E06A2159-48 1 plate of 48 wells
EUR 520
Description: A competitive for quantitative measurement of Goat Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Angiotensin Converting Enzyme ELISA kit

E06A2159-96 1 plate of 96 wells
EUR 685
Description: A competitive for quantitative measurement of Goat Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Active Angiotensin I Converting Enzyme (ACE)

4-APA004Hu02
  • EUR 719.14
  • EUR 295.00
  • EUR 2421.76
  • EUR 873.92
  • EUR 1647.84
  • EUR 544.00
  • EUR 5904.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Angiotensin I Converting Enzyme expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Angiotensin I Converting Enzyme (ACE) Antibody

20-abx128667
  • EUR 356.00
  • EUR 133.00
  • EUR 996.00
  • EUR 495.00
  • EUR 300.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Angiotensin I Converting Enzyme (ACE) Antibody

20-abx129494
  • EUR 356.00
  • EUR 133.00
  • EUR 1024.00
  • EUR 509.00
  • EUR 300.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Angiotensin I Converting Enzyme (ACE) Antibody

20-abx129607
  • EUR 356.00
  • EUR 133.00
  • EUR 1024.00
  • EUR 509.00
  • EUR 300.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Angiotensin-Converting Enzyme 2 (ACE2) Antibody

20-abx313823
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Angiotensin-Converting Enzyme (CD143) Antibody (FITC)

abx413654-01mg 0.1 mg
EUR 578

Angiotensin I Converting Enzyme (ACE) Antibody

20-abx270178
  • EUR 467.00
  • EUR 537.00
  • EUR 272.00
  • EUR 815.00
  • EUR 356.00
  • 100 tests
  • 200 tests
  • 25 tests
  • 500 tests
  • 50 tests

Angiotensin I Converting Enzyme (ACE) Antibody

20-abx270179
  • EUR 467.00
  • EUR 537.00
  • EUR 272.00
  • EUR 815.00
  • EUR 356.00
  • 100 tests
  • 200 tests
  • 25 tests
  • 500 tests
  • 50 tests

Angiotensin I-Converting Enzyme Substrate Peptide

20-abx265670
  • EUR 356.00
  • EUR 537.00
  • EUR 286.00
  • 10 mg
  • 25 mg
  • 5 mg

Angiotensin I Converting Enzyme (ACE) Antibody

20-abx241080
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul

Angiotensin I Converting Enzyme (ACE) Antibody

20-abx241081
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul

Angiotensin I Converting Enzyme (ACE) Antibody

abx159297-100ul 100 ul
EUR 467

Angiotensin I Converting Enzyme (ACE) Antibody

20-abx241727
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul

Angiotensin I Converting Enzyme (ACE) Antibody

20-abx214211
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul

Angiotensin I Converting Enzyme (ACE) Antibody

20-abx175391
  • EUR 1177.00
  • EUR 578.00
  • 1 mg
  • 200 ug

Angiotensin I Converting Enzyme (ACE) Antibody

20-abx175393
  • EUR 1288.00
  • EUR 620.00
  • 1 mg
  • 200 ug

Angiotensin I Converting Enzyme (ACE) Antibody

20-abx171229
  • EUR 718.00
  • EUR 384.00
  • 1 mg
  • 200 ug

Angiotensin I Converting Enzyme (ACE) Antibody

20-abx171230
  • EUR 843.00
  • EUR 439.00
  • 1 mg
  • 200 ug

Angiotensin I Converting Enzyme (ACE) Antibody

20-abx171231
  • EUR 843.00
  • EUR 439.00
  • 1 mg
  • 200 ug

Angiotensin I Converting Enzyme (ACE) Antibody

20-abx171232
  • EUR 913.00
  • EUR 467.00
  • 1 mg
  • 200 ug

Angiotensin I Converting Enzyme (ACE) Antibody

20-abx171233
  • EUR 913.00
  • EUR 467.00
  • 1 mg
  • 200 ug

Angiotensin I Converting Enzyme (ACE) Antibody

abx230080-100ug 100 ug
EUR 481

Angiotensin I Converting Enzyme (ACE) Antibody

20-abx328371
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug

Angiotensin I Converting Enzyme (ACE) Antibody

20-abx325361
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug

Angiotensin I Converting Enzyme (ACE) Antibody

20-abx103103
  • EUR 356.00
  • EUR 133.00
  • EUR 996.00
  • EUR 495.00
  • EUR 300.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Angiotensin I Converting Enzyme (ACE) Antibody

20-abx103104
  • EUR 356.00
  • EUR 133.00
  • EUR 1024.00
  • EUR 509.00
  • EUR 300.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Angiotensin I Converting Enzyme (ACE) Antibody

20-abx103105
  • EUR 453.00
  • EUR 133.00
  • EUR 1288.00
  • EUR 620.00
  • EUR 342.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Angiotensin I Converting Enzyme (ACE) Antibody

abx037354-100ug 100 ug
EUR 391

Angiotensin I Converting Enzyme (ACE) Antibody

abx140499-01mg 0.1 mg
EUR 356

Angiotensin I Converting Enzyme (ACE) Antibody

20-abx007362
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Angiotensin I Converting Enzyme (ACE) Antibody

abx025482-100ul 100 ul
EUR 523

Angiotensin I Converting Enzyme (ACE) Antibody

abx033685-400ul 400 ul
EUR 523

Angiotensin I Converting Enzyme (ACE) Antibody

abx033685-80l 80 µl
EUR 286

Monoclonal Angiotensin Converting Enzyme 1 Antibody

APG01871G 0.1ml
EUR 484
Description: A Monoclonal antibody against Human Angiotensin Converting Enzyme 1. The antibodies are raised in Mouse. This antibody is applicable in WB

Anti-Angiotensin Converting Enzyme 1 antibody

STJ99092 200 µl
EUR 197
Description: Mouse monoclonal to Angiotensin Converting Enzyme 1.

Angiotensin Converting Enzyme 2 Conjugated Antibody

C49072 100ul
EUR 397

Angiotensin I-Converting Enzyme (ACE) Inactivator

N-1360.0250 250.0mg
EUR 576
Description: Sum Formula: C21H21N3O4; CAS# [144085-32-5]

Angiotensin I-Converting Enzyme (ACE) Inactivator

N-1360.1000 1.0g
EUR 1663
Description: Sum Formula: C21H21N3O4; CAS# [144085-32-5]

Rabbit Angiotensin converting enzyme,ACE ELISA Kit

ELA-E0004Rb 96 Tests
EUR 928

Rat Angiotensin converting enzyme,ACE ELISA Kit

CN-01619R1 96T
EUR 447

Rat Angiotensin converting enzyme,ACE ELISA Kit

CN-01619R2 48T
EUR 296

Mouse Angiotensin converting enzyme,ACE ELISA Kit

CN-02491M1 96T
EUR 449

Mouse Angiotensin converting enzyme,ACE ELISA Kit

CN-02491M2 48T
EUR 299

Human Angiotensin converting enzyme,ACE ELISA Kit

CN-03160H1 96T
EUR 438

Human Angiotensin converting enzyme,ACE ELISA Kit

CN-03160H2 48T
EUR 289

Human Angiotensin I Converting Enzyme ELISA kit

E01A0498-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Human Angiotensin I Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Angiotensin I Converting Enzyme ELISA kit

E01A0498-48 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Human Angiotensin I Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Angiotensin I Converting Enzyme ELISA kit

E01A0498-96 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Human Angiotensin I Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Angiotensin I Converting Enzyme ELISA kit

E01A0707-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Human Angiotensin I Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Angiotensin I Converting Enzyme ELISA kit

E01A0707-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Human Angiotensin I Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Angiotensin I Converting Enzyme ELISA kit

E01A0707-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Human Angiotensin I Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Angiotensin II Converting Enzyme ELISA kit

E01A0709-192T 192 tests
EUR 1270
Description: A Sandwich ELISA for quantitative measurement of Human Angiotensin II Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Angiotensin II Converting Enzyme ELISA kit

E01A0709-48 1 plate of 48 wells
EUR 520
Description: A Sandwich ELISA for quantitative measurement of Human Angiotensin II Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Angiotensin II Converting Enzyme ELISA kit

E01A0709-96 1 plate of 96 wells
EUR 685
Description: A Sandwich ELISA for quantitative measurement of Human Angiotensin II Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Angiotensin I Converting Enzyme ELISA kit

E02A0498-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Rat Angiotensin I Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.