Tag: isotopes in medicine

August 22, 2020

Melatonin on Elevated Liver Enzymes During Statins Treatment

The Effects of Melatonin on Elevated Liver Enzymes During Statins Treatment Introduction Statins are widely used in the treatment and prevention of lipid metabolism disorders. They are generally well tolerated but not devoid of side effects. These include, among others, muscular symptoms, arthritis, headaches, gynecomastia. Myositis and rhabdomyolysis associated with increased activity of creatinine kinase and serum creatinine levels are rare but serious adverse events […]

August 22, 2020

Repeated Doses of Foliglurax on Drug Metabolizing Enzymes in Healthy Subjects

Results of Repeated Doses of Foliglurax on Drug Metabolizing Enzymes in Wholesome Topics This research is designed to guage the PK of caffeine, montelukast and midazolam following a number of doses of foliglurax in wholesome topics. The research is split into 4 intervals: – Interval 1: an investigation of the CYP450 probe substrates (caffeine, montelukast, midazolam) alone adopted by a 2-day washout earlier than begin […]